Protein Alignment DGKG and dgkg

DIOPT Version :10

• Sequence 1: NP_001337.2
• Gene: DGKG / 1608
• HGNCID: 2853
• Length: 791
• Species: Homo sapiens
• Sequence 2: XP_073768719.1
• Gene: dgkg / 567728
• ZFINID: ZDB-GENE-081105-39
• Length: 893
• Species: Danio rerio
• Alignment Length: 902
• Identity: 531/902 - (58%)
• Similarity: 637/902 - (70%)
• Gaps: 120/902 - (13%)

Human     1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDP-------HEPISYDVFKLF 58
            ||:  ||.|:|.||.|||:||||||||:||.|.||:..|.|.:|:|       ::||.|:.|:||
Zfish     1 MGD--WVCLSPAEFSQLQQYSEYSSKKLKDVLEEFHGNGVLSKYNPEQKQDVLNQPIDYEGFQLF 63

Human    59 MRAYLEVDLPQPLSTHLFLAFSQKPRHETS-DHPTEGASNSEANSADTNIQNADNATKADEACAP 122
            |..|||.|:|:.|..|||.:|..|...|.| |....||...|..|.|..|     :.:.:.||||
Zfish    64 MTTYLENDIPEELCKHLFTSFKSKNGGEGSPDTSRAGAGILEPKSIDAGI-----SIQTEVACAP 123

Human   123 DTESN-----MAEKQAPAEDQVAATP-----------------------------------LEPP 147
            .|..|     .|..:..||.....||                                   .:||
Zfish   124 ITGMNGKSILSAMSRHTAESSAGITPGSGATTSPCSSRSSSQRSGTGGHTPRGPHRSPGTQPKPP 188

Human   148 VPRSSSSE-------------------------------------SP-VVYLKDVVCYLSLLETG 174
            ...||||.                                     || ||:|||:||||||||.|
Zfish   189 TGSSSSSNALALSKTSNSPRLSPERNQSENRTSLRRSPSPQKGSPSPQVVFLKDIVCYLSLLERG 253

Human   175 RPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGF 239
            .|:|||||||||||:|.|||||.:|:|.|:|||:|:|:|||||.||||||||||::.:||||||.
Zfish   254 TPEDKLEFMFRLYDTDGNGLLDSSELDRIINQMVHVAEYLEWDSTELRPILKEMMEEIDYDRDGT 318

Human   240 VSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTY 304
            |:|:||:.|||||||||||||| ::..:.||:|.|.:|||.||.|||:||.||:|||||||||..
Zfish   319 VTLEEWIRGGMTTIPLLVLLGM-ETNVQEDGQHIWKLKHFNKPAYCNYCHTMLLGVRKQGLCCAL 382

Human   305 CKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWC 369
            |||||||||||::|..|:.||:|::|....|||.|:|||||.|||:||:||||||.:|..|||||
Zfish   383 CKYTVHERCVSKDIAPCISTYAKSRRHTNAMQHVWMEGNSSAKCDKCHRSIKCYQGLTGLHCVWC 447

Human   370 RMTFHRKC--ELSTLCDGGELRDHILLPTSICPITRDR-------PGEKSDG--------CVSAK 417
            ::|.|.||  .:...||||.||||.|||:.|||:..||       .||.|..        |....
Zfish   448 QITLHNKCASNMKPECDGGPLRDHTLLPSYICPVVLDRHSAVKRGEGESSPSTSPEDTGQCFKFT 512

Human   418 GELVMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDT 482
            |: ....:|.|.|||||||||||||||||||||:||||.|||||:||::|:.|||..|||||||.
Zfish   513 GD-GQALQITPLPGTHPLLVLVNPKSGGRQGERVLRKFQYLLNPRQVYSLERGGPMAGLNFFRDV 576

Human   483 PDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDI 547
            ||||||||||||:|||||||||||:||:|||||:||||||||||||||||||||||||.|.|:||
Zfish   577 PDFRVLACGGDGSVGWILDCIDKASFARHPPVAILPLGTGNDLARCLRWGGGYEGGSLVKFLRDI 641

Human   548 EQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKN 612
            |.|..|:||||:::::|.::.|.||.|||||:|||||||||||||||||:|||||||||||||||
Zfish   642 EHSTEVLLDRWNIDIVPDDKEEKGDPVPYSIVNNYFSIGVDASIAHRFHLMREKHPEKFNSRMKN 706

Human   613 KLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNR 677
            |||||||||:||.:||||||::.||:||||:.:|||:..|||||:||||||:||:|||||.||.|
Zfish   707 KLWYFEFGTTETISATCKKLNETIEVECDGIILDLSSTSLEGIAVLNIPSMHGGSNLWGETKKRR 771

Human   678 AVIRESRK--------GVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCA 734
            ...|.|:|        .|||.|||||||||||||||||||||||:|||||||||||||||||||:
Zfish   772 NYNRMSKKVPERMTGSTVTDAKELKFCVQDLSDQLLEVVGLEGAIEMGQIYTGLKSAGRRLAQCS 836

Human   735 SVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD 791
            :|||||::|||||:||||||||.|||:||||||.||::|||||:.||..::::||:|
Zfish   837 NVTIRTSRLLPMQIDGEPWMQPPCTIRITHKNQVPMLLGPPQKTPFFFFKKRNRSRD 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DGKG	NP_001337.2	DAG_kinase_N	5..175	CDD:464196	85/255 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..103		7/21 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..154		15/76 (20%)
		EFh	179..248	CDD:238008	49/68 (72%)
		C1	255..328	CDD:412127	47/72 (65%)
		C1_DGKgamma_rpt2	337..395	CDD:410442	37/59 (63%)
		DAGKc	436..557	CDD:214487	99/120 (83%)
		DAGKa	578..752	CDD:214486	140/181 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..791		11/22 (50%)
dgkg	XP_073768719.1	None