Protein Alignment DGKG and dgk-3

DIOPT Version :10

• Sequence 1: NP_001337.2
• Gene: DGKG / 1608
• HGNCID: 2853
• Length: 791
• Species: Homo sapiens
• Sequence 2: NP_499031.3
• Gene: dgk-3 / 186262
• WormBaseID: WBGene00000960
• Length: 795
• Species: Caenorhabditis elegans
• Alignment Length: 823
• Identity: 385/823 - (46%)
• Similarity: 522/823 - (63%)
• Gaps: 71/823 - (8%)

Human     9 LTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQY--DPHEPISYDVFKLFMRAYLEVDLPQPL 71
            |:||:|.:|.:|:.||.:|:||.|::|.:.|....|  ...:.|:.|.|:.|:..|...|||..|
 Worm     3 LSPEQFSRLSEYAAYSRRKLKDMLSDFQQDGKFYSYLSVDGQTINIDGFRAFLIDYFGADLPSDL 67

Human    72 STHLFLAFSQKPRHETSDHPTEGASN------SEANS---ADTNI-----QNADNATKADE---A 119
            ...|||:||:.|..|......|.|.:      ||:.|   |..||     |..|.:..::.   .
 Worm    68 VDQLFLSFSKPPIKERRTSLFEDAISTVRAKFSESLSGRMAGLNIAGGSGQQTDRSQSSEPQALV 132

Human   120 CAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMF 184
            |.|             ||.|    :.|.|..:.|.| |.:.||.::|.|||||...|::||:.:|
 Worm   133 CIP-------------EDDV----MGPRVANNDSQE-PRIPLKPLICTLSLLEADTPENKLDVVF 179

Human   185 RLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGG 249
            .:||||.||.||::|:|.|:.||:::|:|.:||..||..::::|:..:|||.||.||..||..||
 Worm   180 HVYDSDGNGFLDKSEIDGIIEQMMNVARYQQWDTIELEQVIRQMMVDIDYDNDGIVSFDEWRRGG 244

Human   250 MTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMG-VRKQGLCCTYCKYTVHERC 313
            :|.||||||||. |:..|.||.|.|.::||.||||||.|..:|:| ..||||.|:.|||||||||
 Worm   245 LTNIPLLVLLGF-DTEMKEDGSHVWRLRHFTKPTYCNACCSILVGWGGKQGLSCSLCKYTVHERC 308

Human   314 VSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKC- 377
            |......|::|||  .|..:.:.|.|.:.|::.||.:|..::..:|   .:.|.||....|.:|
 Worm   309 VRSAATNCIRTYS--SRQQDKLYHHWQDANATAKCVKCKATVGVFQ---GKGCRWCHNYVHHRCM 368

Human   378 -ELSTLCDGGELRDHILLPTSICPITRDRPGEKS--DGCVSAKGELVMQYKIIPTPGTHPLLVLV 439
             .|:..||.|.|..|||.||.|.|...:|....|  :...|:....::| .:.|:....||||||
 Worm   369 SALAQECDLGALVHHILPPTHIFPAFLERKTSTSLKNHNFSSHSASLLQ-AVSPSNDCRPLLVLV 432

Human   440 NPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCID 504
            ||||||:||.:||:||.|||||:||::|...||.|||..|....:..:|.||||||:||:|:.:|
 Worm   433 NPKSGGKQGVKILQKFEYLLNPRQVYDLSKTGPEPGLQLFSTLKNCNILVCGGDGTIGWVLESMD 497

Human   505 KANFAK-HPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEV------ 562
            |..|.. .|||||||||||||||||||||||||..:|.|||:.||:|.|:.:|||.:::
 Worm   498 KMTFPHGRPPVAVLPLGTGNDLARCLRWGGGYENENLHKILEQIEKSSLIDMDRWQIKIEITENK 562

Human   563 IPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAA 627
            ..|...|.||..||||:||||||||||||||||||||||.||||||||:|||||||.|||||.::
 Worm   563 SARRASEKGDTPPYSIINNYFSIGVDASIAHRFHVMREKFPEKFNSRMRNKLWYFELGTSETLSS 627

Human   628 TCKKLHDHIELECDGVGVDL-SNIFLEGIAILNIPSMYGGTNLWGENKKNRA------VIRESRK 685
            :||.||:.|::.|||..:|| .:..|||||:|||||:|||:||||.::|::.      .::.:.|
 Worm   628 SCKNLHEQIDILCDGESIDLGQDASLEGIALLNIPSIYGGSNLWGRSRKSKGRMPGLFPMKNAEK 692

Human   686 GVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDG 750
                 .:|:..|||:.|.|:|:||||.||:||||..|::.| |||:||::|.|:|:|..|||:||
 Worm   693 -----MQLQTRVQDIGDGLIELVGLESAMQMGQIKAGVRGA-RRLSQCSTVVIQTHKSFPMQIDG 751

Human   751 EPWMQPCCTIKITHKNQAPMMM--GPPQKSSFFSLRRKSRSKD 791
            ||||||.|.|:|||||||.|::  .|.::||:..|:|:|.:.|
 Worm   752 EPWMQPPCIIQITHKNQAKMLVAAAPRKRSSWMLLKRQSTNDD 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DGKG	NP_001337.2	DAG_kinase_N	5..175	CDD:464196	59/184 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..103		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..154		7/39 (18%)
		EFh	179..248	CDD:238008	32/68 (47%)
		C1	255..328	CDD:412127	42/73 (58%)
		C1_DGKgamma_rpt2	337..395	CDD:410442	20/59 (34%)
		DAGKc	436..557	CDD:214487	76/121 (63%)
		DAGKa	578..752	CDD:214486	105/180 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..791		8/24 (33%)
dgk-3	NP_499031.3	DAG_kinase_N	2..170	CDD:464196	59/184 (32%)
		EFh	174..243	CDD:238008	32/68 (47%)
		C1_DGK_typeI_rpt1	261..323	CDD:410349	35/63 (56%)
		C1_DGK_typeI_like_rpt2	330..378	CDD:410401	15/50 (30%)
		DAGKc	429..551	CDD:214487	76/121 (63%)
		DAGKa	578..753	CDD:214486	105/180 (58%)