Protein Alignment DGKG and Dgkg

DIOPT Version :10

• Sequence 1: NP_001337.2
• Gene: DGKG / 1608
• HGNCID: 2853
• Length: 791
• Species: Homo sapiens
• Sequence 2: XP_017172339.1
• Gene: Dgkg / 110197
• MGIID: 105060
• Length: 834
• Species: Mus musculus
• Alignment Length: 837
• Identity: 709/837 - (84%)
• Similarity: 745/837 - (89%)
• Gaps: 49/837 - (5%)

Human     1 MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMRAYLEV 65
            |.||:||||:.|||||||||||||||||||.|.||||||||:|||||:|||||||||||||||||
Mouse     1 MSEEQWVSLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLRQYDPHKPISYDVFKLFMRAYLEV 65

Human    66 DLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEACAPDTESNMAE 130
            |||||||||||||||||||.||.|||.||||:||.|.:|   .|:|||.||||||||||||...:
Mouse    66 DLPQPLSTHLFLAFSQKPRQETPDHPKEGASSSEPNVSD---YNSDNAAKADEACAPDTESKTTK 127

Human   131 KQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMFRLYDSDENGLL 195
            .|||:::..||.|.|.|...:|||::||||||||||||||:||||||||||||||||||||||||
Mouse   128 TQAPSKELEAAAPWEDPGALASSSDAPVVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENGLL 192

Human   196 DQAEMDCIVNQMLHIAQYLEWDPTELRP------------------------------------- 223
            ||||||.||:||||:|||||||||||||
Mouse   193 DQAEMDQIVSQMLHVAQYLEWDPTELRPERCLRQQDEVYTWQKLQFPSLPSRGNSMIETQRTEKL 257

Human   224 ---------ILKEMLQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHF 279
                     ||||||||||||:|||||||||::||||||||||||||||||||||||||||:|||
Mouse   258 EPSVEELSMILKEMLQGMDYDKDGFVSLQEWINGGMTTIPLLVLLGMDDSGSKGDGRHAWTLKHF 322

Human   280 KKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNS 344
            |||||||||..|||||.||||||.|||||||:||||:.|.|||||.|||||||||||||||||||
Mouse   323 KKPTYCNFCRAMLMGVGKQGLCCIYCKYTVHQRCVSKTIHGCVKTNSKAKRSGEVMQHAWVEGNS 387

Human   345 SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEK 409
            |||||||||||||||||||||||||||||||||||||:||||||:|||||||||||::.||.|.|
Mouse   388 SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTVCDGGELKDHILLPTSICPVSGDRQGGK 452

Human   410 SDGCVSAKGELVMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTP 474
            |||.|:||||||.||||||:||||||||||||||||||||||||||||||||:||||||||||||
Mouse   453 SDGSVAAKGELVTQYKIIPSPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPEQVFNLDNGGPTP 517

Human   475 GLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS 539
            |||||.||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||
Mouse   518 GLNFFHDTPDFRVLACGGDGTVGWILDCIDKANFTKHPPVAVLPLGTGNDLARCLRWGGGYEGGS 582

Human   540 LTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPE 604
            ||||||:||||||||||||:|||:|||||||||||||:|||||||||||||||||||:|||||||
Mouse   583 LTKILKEIEQSPLVMLDRWYLEVMPREEVENGDQVPYNIMNNYFSIGVDASIAHRFHMMREKHPE 647

Human   605 KFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNL 669
            |||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||
Mouse   648 KFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVEVDLSNIFLEGIAILNIPSMYGGTNL 712

Human   670 WGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCA 734
            |||.||||||||||||.||||||||.||||||||||||||||||||||||||||||||||||||:
Mouse   713 WGETKKNRAVIRESRKSVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCS 777

Human   735 SVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD 791
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
Mouse   778 SVTIRTNKLLPMQVDGEPWMQPQCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DGKG	NP_001337.2	DAG_kinase_N	5..175	CDD:464196	129/169 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..103		15/20 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..154		19/36 (53%)
		EFh	179..248	CDD:238008	63/114 (55%)
		C1	255..328	CDD:412127	62/72 (86%)
		C1_DGKgamma_rpt2	337..395	CDD:410442	55/57 (96%)
		DAGKc	436..557	CDD:214487	116/120 (97%)
		DAGKa	578..752	CDD:214486	167/173 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..791		22/22 (100%)
Dgkg	XP_017172339.1	DAG_kinase_N	5..172	CDD:464196	129/169 (76%)
		EFh	176..291	CDD:238008	63/114 (55%)
		C1	298..371	CDD:412127	62/72 (86%)
		C1_DGKgamma_rpt2	380..438	CDD:410442	55/57 (96%)
		DAGKc	479..600	CDD:214487	116/120 (97%)
		DAGKa	621..795	CDD:214486	167/173 (97%)