Protein Alignment DGKG and dgkb

DIOPT Version :10

• Sequence 1: NP_001337.2
• Gene: DGKG / 1608
• HGNCID: 2853
• Length: 791
• Species: Homo sapiens
• Sequence 2: XP_031759028.1
• Gene: dgkb / 100124765
• XenbaseID: XB-GENE-5870147
• Length: 795
• Species: Xenopus tropicalis
• Alignment Length: 823
• Identity: 499/823 - (60%)
• Similarity: 600/823 - (72%)
• Gaps: 72/823 - (8%)

Human     3 EERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHE-------PISYDVFKLFMR 60
            :|:||:|:|.||.|||||:|||:||:||.|.||:..|.|.:|:|.|       .|.::.|:|||:
 Frog     7 QEKWVNLSPAEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEEKQDILKQAIDFEGFQLFMK 71

Human    61 AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEG-ASNSEANSADTNIQNADNATKADEACAPDT 124
            .:||.:||.....|||::||.:     ..:|:.. .|.|:..|....:....|::
 Frog    72 TFLEAELPDEFCKHLFMSFSNR-----FHNPSPSIQSKSQLLSGGLRMNYRSNSS---------- 121

Human   125 ESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMFRLYDS 189
                :...:|..       |.||         .|:.|||:||||||||.|||:|||||||||||:
 Frog   122 ----SRSSSPVS-------LRPP---------DVIQLKDIVCYLSLLERGRPEDKLEFMFRLYDT 166

Human   190 DENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGGMTTIP 254
            |.||.||..|::.|:.||:|:|:|||||.|||.|||.||::.:|||.||.|||:||:.|||||||
 Frog   167 DGNGYLDSTELESIITQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIP 231

Human   255 LLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIP 319
            ||||||:::: .|.||:|.|.:|||.||.|||.|..||:|:.||||||::||||||||||||..|
 Frog   232 LLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLCLNMLIGLGKQGLCCSFCKYTVHERCVSRAPP 295

Human   320 GCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKC--ELSTL 382
            .|:|||.|:|:...||.|.|||||...||::|||:|||||.:|..|||||::|.|.||  .|...
 Frog   296 SCIKTYVKSKKDTNVMHHFWVEGNCPTKCEKCHKAIKCYQGLTGLHCVWCQITLHNKCASHLKPE 360

Human   383 CDGGELRDHILLPTSICPITRDRPG--EKSDGCVSAKG-----ELVMQ-----------YKIIPT 429
            ||.|.|:||||.||:|||:..:|..  ::...| |.:|     .:.||           .:|.|.
 Frog   361 CDCGPLKDHILPPTTICPVVLERQSTLKREKNC-SQQGNKCGERIKMQRANSVTVDGQGLQITPI 424

Human   430 PGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDG 494
            .|||||||.|||||||:|||||.|||.|||||:||::|...||.||||||||.|||:||||||||
 Frog   425 SGTHPLLVFVNPKSGGKQGERIHRKFQYLLNPRQVYSLAGIGPMPGLNFFRDVPDFKVLACGGDG 489

Human   495 TVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWH 559
            |||||||||||||..|.||||||||||||||||||||||||||.:|.|.|||||.:.:|:||||.
 Frog   490 TVGWILDCIDKANLIKQPPVAVLPLGTGNDLARCLRWGGGYEGENLMKFLKDIEIATVVLLDRWK 554

Human   560 LEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSET 624
            ::|||.::.|.||.|||||:|||||||||||||||||:||||||||||||||||.||||||||||
 Frog   555 IDVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHLMREKHPEKFNSRMKNKFWYFEFGTSET 619

Human   625 FAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKG--- 686
            |:|||||||:.||:||||:.:||.||.||||||||||||:||:|||||.||.|:..|..:|.
 Frog   620 FSATCKKLHEAIEIECDGIQMDLGNISLEGIAILNIPSMHGGSNLWGETKKRRSNRRTDKKNSDK 684

Human   687 ---VTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQV 748
               |||.|||||..||||||||||||||||||||||||||||||||||||:||.:||:|.||||:
 Frog   685 RTTVTDAKELKFAAQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVLRTSKSLPMQI 749

Human   749 DGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFF-SLRRKSRSK 790
            |||||||..|||||||||||||:||||.|:..| ||.:.||||
 Frog   750 DGEPWMQTPCTIKITHKNQAPMLMGPPPKNGLFTSLIKGSRSK 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DGKG	NP_001337.2	DAG_kinase_N	5..175	CDD:464196	61/177 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..103		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..154		4/36 (11%)
		EFh	179..248	CDD:238008	44/68 (65%)
		C1	255..328	CDD:412127	46/72 (64%)
		C1_DGKgamma_rpt2	337..395	CDD:410442	35/59 (59%)
		DAGKc	436..557	CDD:214487	95/120 (79%)
		DAGKa	578..752	CDD:214486	141/179 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..791		15/24 (63%)
dgkb	XP_031759028.1	DAG_kinase_N	9..152	CDD:464196	61/177 (34%)
		EFh	156..225	CDD:238008	44/68 (65%)
		C1_DGKbeta_rpt1	241..306	CDD:410395	41/65 (63%)
		C1_DGKbeta_rpt2	311..369	CDD:410441	32/57 (56%)
		DAGKc	431..552	CDD:214487	95/120 (79%)
		DAGKa	573..753	CDD:214486	141/179 (79%)