Protein Alignment SLC5A8 and Smvt

DIOPT Version :10

• Sequence 1: NP_666018.3
• Gene: SLC5A8 / 160728
• HGNCID: 19119
• Length: 610
• Species: Homo sapiens
• Sequence 2: NP_651891.2
• Gene: Smvt / 43744
• FlyBaseID: FBgn0039873
• Length: 591
• Species: Drosophila melanogaster
• Alignment Length: 585
• Identity: 217/585 - (37%)
• Similarity: 315/585 - (53%)
• Gaps: 40/585 - (6%)

Human    10 FVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGT 74
            |...||.|||.:|.||||||:|:.|...|:.|::::||||:||..:|:|:||.||.:||::::..
  Fly    24 FNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMTI 88

Human    75 PSEVYRFGA--IFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIV 137
            |:|:|.:|.  :|::....  .||.:...:.:||||...||:.|||||:||.:.||:..|.:||:
  Fly    89 PAEMYAYGINWVFNVVCMV--LVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVRVLQTFIFIL 151

Human   138 QTILYTGIVIYAPALALNQVTGFD--LWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGF 200
            .......|.|:.|:||..|||||:  |...||.:  :|.||...||:|||:||||.|..||||..
  Fly   152 TMFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCS--ICVFYTMFGGIKAVVWTDVIQAAIMVASV 214

Human   201 ASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQ 265
            ..|.:......||...:|..|.:||||:. |:|.:...|.|.|.|....|..||...|:|||.||
  Fly   215 VLVGVLGAHRVGGFFEVLRIAGEGGRLDI-NYNFDLTTRSTIWNIFTSATMMWTGYVGLNQSCVQ 278

Human   266 RYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDI 330
            |.:|..|...|:.||.:...|...|:..:.|.|:.:|||:|||||..:..||..|:::||.|.|.
  Fly   279 RIVSLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYFVQDT 343

Human   331 LQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVYGAL 395
            :.:..|:||:|::|.:|..|||:|:|||:|..|...|.|||:.|....|: :.|.:......|..
  Fly   344 VGNLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPHIRHTEHRA-NVIMKLFVFFTGIY 407

Human   396 CIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGI-- 458
            ||....:.....::||...|:.||..|...|:|.||:|||.::...||||::|..|....:.|
  Fly   408 CILGGMVIENFNSILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATIVILS 472

Human   459 -GAQIYPPLPERTLPLHLDIQGC---NSTYNETNLMTTTEMPFTTSVFQIYNVQRTPLMDNWYSL 519
             |...|..||..|......:.|.   .||.:...|.:|||.|.....|.|.:     |..|||::
  Fly   473 WGRNHYDTLPTSTSACPASLNGTIKDISTASPLFLGSTTEAPVGEKEFSILD-----LSFNWYTV 532

Human   520 SYLYFSTVGTLVTLLVGILVS--LSTG-GRKQN---LDP------RYILTKEDFLSNFDIFKKKK 572
            :       |.::|.|:||.:|  |.:| ..|.|   |.|      .|.||..|.....::.|.:|
  Fly   533 T-------GFVITWLIGIPLSYILKSGPDYKPNPKLLSPVVQPFVHYKLTPSDEPHQLNLEKPEK 590

Human   573  572
              Fly   591  590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A8	NP_666018.3	SLC5sbd_SMCT1	7..549	CDD:271402	208/551 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..610
		PDZ-binding. /evidence=ECO:0000269|PubMed:30604288	608..610
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	204/538 (38%)