Protein Alignment SLC5A8 and CG2187

DIOPT Version :10

• Sequence 1: NP_666018.3
• Gene: SLC5A8 / 160728
• HGNCID: 19119
• Length: 610
• Species: Homo sapiens
• Sequence 2: NP_651890.1
• Gene: CG2187 / 43743
• FlyBaseID: FBgn0017448
• Length: 623
• Species: Drosophila melanogaster
• Alignment Length: 557
• Identity: 184/557 - (33%)
• Similarity: 297/557 - (53%)
• Gaps: 47/557 - (8%)

Human    10 FVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGT 74
            |.:.||.||..||..||.||:|:.|....:.|::::|.||::|..:|:|:||.||.:|.:.::..
  Fly    24 FGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSI 88

Human    75 PSEVYRFGAIFSIFAFTYFFVVV-------ISAEVFLPVFYKLGITSTYEYLELRFNKCVRLCGT 132
            |:|.|.:|       |.|.|||:       |...:.:||||:..:::.|||||:||||..|...|
  Fly    89 PAESYTYG-------FNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVT 146

Human   133 VLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMV 197
            ..|:..:.|...:.::.|:||..||||.::....|....:|.||..|||:|||:||||.|..||:
  Fly   147 FFFVTNSFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIML 211

Human   198 AGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQS 262
            ....:|.:...:..||:.|::..|.||||.|| :|..:|..|.|||...:||.|.||...|:|||
  Fly   212 LSVVAVGVLGTIRSGGMFTVMERASDGGRFNF-DFGLDPRIRMTFWGATMGGIFMWTGHIGLNQS 275

Human   263 QVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLV 327
            .|||.:|..|...||.||.::.:|...|...:...|:.:::||:.|||..|..||.||::||:.|
  Fly   276 CVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFV 340

Human   328 LDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVY 392
            .||:....|:||:|::|.:|..||::|:::|:||.|...|.|||..|....|: :|..:.:.||.
  Fly   341 QDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRHTEARA-NWAMKLIVVVM 404

Human   393 GALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVG 457
            |..||....:.....::||..:::.|:..|.::|:|.||:.||..|:..|:..::......:|:.
  Fly   405 GGYCILGGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWII 469

Human   458 IGAQI--------YPPLPE-----RTLPLHLDIQGCNST-YNETNLMTTTEMPFTTSV-----FQ 503
            ...|:        |..||.     ....|::..:..|.| :....:...:..|.||:.     |.
  Fly   470 ANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFS 534

Human   504 IYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVS 540
            :|::            |:.::..:|:.:..|..|.:|
  Fly   535 LYDI------------SFYWYKVLGSALVFLCAIPLS 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A8	NP_666018.3	SLC5sbd_SMCT1	7..549	CDD:271402	184/557 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..610
		PDZ-binding. /evidence=ECO:0000269|PubMed:30604288	608..610
CG2187	NP_651890.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	183/554 (33%)