Protein Alignment SLC5A8 and salt

DIOPT Version :10

• Sequence 1: NP_666018.3
• Gene: SLC5A8 / 160728
• HGNCID: 19119
• Length: 610
• Species: Homo sapiens
• Sequence 2: NP_651889.3
• Gene: salt / 43742
• FlyBaseID: FBgn0039872
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 641
• Identity: 204/641 - (31%)
• Similarity: 322/641 - (50%)
• Gaps: 89/641 - (13%)

Human    10 FVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGT 74
            |.:.||:||:.||..||.||:|:.|....:.|::::|.||:||..:|||:||.:|.:|.|.::..
  Fly    25 FSLTDYIVFSLMLSASAGIGVYFGFFSKAKNTTEEYLQGGKRMPTLPVAISLVSSQLSGVAMMSV 89

Human    75 PSEVYRFG--AIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIV 137
            |:|.|.||  .||.::|......|:|  .:.:||||...:::.||||||||:|..|...|:.||:
  Fly    90 PAETYSFGFNMIFVVWAMVLSVPVLI--YIIVPVFYDNNVSNCYEYLELRFSKRTRQLVTITFIL 152

Human   138 QTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFAS 202
            ...|...:.::.|:||.:||||:::.........:|.||..|||:|||:||||.|..:|:.....
  Fly   153 NQFLMLPVYMFVPSLAFSQVTGYNIHLINTVVSSICVFYTMLGGIKAVVWTDVVQGSVMLISVVL 217

Human   203 VIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRY 267
            |.|......|||:.:|.:|.:|||.:| :|..:|..|.||.:.:..|...||...|::||.|||.
  Fly   218 VAILGTSNTGGITNVLENAAEGGRFDF-SFGIDPRLRLTFISGMASGLLMWTGKLGLDQSCVQRI 281

Human   268 ISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQ 332
            :|..|...||..|.:..||...|::.:.|.|:.:::.|:.|||..|..||.||:|||:.:.||:.
  Fly   282 VSLPSYGHAKRCLLMAGVGFLLIMSFTCFTGIIMFAYYYGCDPIQAGLVSKPDKLMPFFIQDIMG 346

Human   333 DYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVYGALCI 397
            ...|:||:|::|.:|.:||::|:|:|:.|.|...|.|||.... ||...:...:.:.||.||.||
  Fly   347 HMMGMPGVFISCVFSASLSSLSASLNSFAGVVYFDYIKPRINH-SEAKANATMKLVIVVMGAYCI 410

Human   398 GMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGIGAQI 462
            ....:.....:::|...::.|:..|.::|:|.||:.||..|:..|:.|:.....:.||:.|..|:
  Fly   411 VGGFIVQNFNSIIQTMWTITGINMGAVVGVFCLGMFVPRCNAKVAVSGIAFSCLVMLWIIINGQM 475

Human   463 --------YPPLPERTLPLHLDIQGCNS-----------TYNETNLMTTT----EMP--FTTSV- 501
                    |.|||.       .:..|.:           ..|.||:.||.    |.|  .||:.
  Fly   476 NFKAGLIKYDPLPN-------GLDQCEAKGFEVILNAIRNKNVTNVGTTAIPSLEAPKELTTAFD 533

Human   502 ----FQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLDPRYI--LTKED 560
                |.||:.            |:.::..:|.|:.....|.:|             |:  |.||:
  Fly   534 SNRDFSIYDT------------SFYWYKVLGALLVFAWAIPMS-------------YVWPLDKEE 573

Human   561 -----FLSNF--DIFKKKKHVLSYKSHPVEDGGTDNPAFNHIELNSDQ-SGKSNGT 608
                 ..|.|  .:..|...||..:..|::           ..|:.:| ..|.||:
  Fly   574 KQNPKLYSPFVRSMLNKPSPVLELEELPLK-----------TPLSEEQIKEKENGS 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A8	NP_666018.3	SLC5sbd_SMCT1	7..549	CDD:271402	189/570 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..610		5/25 (20%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:30604288	608..610		0/1 (0%)
salt	NP_651889.3	SLC5sbd_NIS-SMVT	28..566	CDD:271383	188/573 (33%)