Protein Alignment SLC5A8 and CG7720

DIOPT Version :10

• Sequence 1: NP_666018.3
• Gene: SLC5A8 / 160728
• HGNCID: 19119
• Length: 610
• Species: Homo sapiens
• Sequence 2: NP_650753.1
• Gene: CG7720 / 42257
• FlyBaseID: FBgn0038652
• Length: 681
• Species: Drosophila melanogaster
• Alignment Length: 623
• Identity: 188/623 - (30%)
• Similarity: 315/623 - (50%)
• Gaps: 52/623 - (8%)

Human    13 WDYVVFAGMLVISAAIGIYYAFAGGGQQTSK-DFLMGGRRMTAVPVALSLTASFMSAVTVLGTPS 76
            |||::|...:.::....::....|..::.|| |::.....::.|.|.:|:....:...:|||.||
  Fly    10 WDYLMFVLFIALTVLGPLWKRIFGKKKERSKADYVFATGGVSIVAVMISIARGTLGVRSVLGYPS 74

Human    77 EVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRF-NKCVRLCGTVLFIVQTI 140
            |:|..|:......:.......|...:|:||::.|||||.|:|::||| ::.||...:..:||:.|
  Fly    75 ELYYRGSAMWEIIYGMMSAYPIVCFMFVPVYFNLGITSVYQYIDLRFKSRTVRCLASATYIVRQI 139

Human   141 LYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVII 205
            ...||.:|.|::||:.|.|...|.::....|:|.|:..:|||||.|..||.|...::....:|.|
  Fly   140 CNLGITVYTPSVALSTVIGIPYWASITGMAVICIFFTIMGGLKAAINADVIQTVTILVVTVAVCI 204

Human   206 QAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISC 270
            |..:..||:..:.....|.||||||||..:...|....:..:|..|...|..|..|:.:|||:|.
  Fly   205 QGTISTGGVKKVYQLNRDNGRLNFWNFTGDMTVRVDTTSAWLGQLFMSLSQIGCQQNFMQRYVSL 269

Human   271 KSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYP 335
            ||..|.:..:..|:..::...:.|...|:.:||.|.:|||:....:..||:::|:.|.|.|...|
  Fly   270 KSLKQVRRVMLTNVPLVFFFFSISWISGMVIYSTYINCDPYAEGYIKKPDEILPFFVEDQLGFLP 334

Human   336 GLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIK--PYFRSLSERSLSWISQGMSVVYGALCIG 398
            |..|:|:|..::|.|..:.|::|:||.|..||.|.  |.|:.||::....|.:.::||.|.:.:|
  Fly   335 GFVGIFMATLFNGALCMMVSNLNSLATVIWEDFISQLPKFKGLSDKQQLRILKSITVVCGLIIMG 399

Human   399 MAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGIGAQIY 463
            :|....|:..:::::|.||....|||:|.|.|.::||.||..|...|::...|..||: ||..:.
  Fly   400 VAFGVGLLAGVIESSLLVFSATSGPLLGCFILAMMVPIANWKGTSAGMVTACAFVLWI-IGGGMT 463

Human   464 PPLPERTLPLHLDIQGC-NSTYNET---NLMTTTEMPFTTSVFQI--YNVQRTPL---------- 512
            .......||...|  || |.|:.::   .::...:||:..|...|  :|....|.
  Fly   464 VTKDNPLLPTSTD--GCTNDTFAQSIGKPIVEQGQMPWLLSHTPIDGFNQSFVPTQPTIAPERSG 526

Human   513 MDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLDPRYILTKEDFLSNFDIFK-------K 570
            ::.:||:|::|:|.:||.:|:::|.::||.|    |:.|..|    :..|.:..||:       :
  Fly   527 LETFYSISFMYYSLIGTALTVIIGTVISLLT----QHPDDAY----DGKLLHPLIFRLCERFSGR 583

Human   571 KKHVLSYKSHPVEDGGTDNPAFNHIELNSDQSGKSNGT 608
            |.:   |..|..|.|           ||...|..|:.|
  Fly   584 KPY---YVKHEEESG-----------LNGRSSSDSSAT 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A8	NP_666018.3	SLC5sbd_SMCT1	7..549	CDD:271402	172/555 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..610		6/24 (25%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:30604288	608..610		1/1 (100%)
CG7720	NP_650753.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	170/548 (31%)