Protein Alignment SLC5A8 and SLC5A11

DIOPT Version :10

• Sequence 1: NP_666018.3
• Gene: SLC5A8 / 160728
• HGNCID: 19119
• Length: 610
• Species: Homo sapiens
• Sequence 2: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 206/607 - (33%)
• Similarity: 319/607 - (52%)
• Gaps: 70/607 - (11%)

Human    14 DYVVFAGMLVISAAIGIYYA---------------------------FAGGGQQTSKDFLMGGRR 51
            ||.||.||:|:|.:.|||:.                           |   |.:...::|:|.|.
  Fly    18 DYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDF---GSEKMSEYLLGSRN 79

Human    52 MTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTY 116
            :...|||:||.||::|.||:|||.||:|.:|..:...|.......:..:.|::|||..|.:.|:|
  Fly    80 LKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSALQVGSSY 144

Human   117 EYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGG 181
            ||||:||:..||...:.:||:..||:...::|.||:|||||:|.:|....|...|||.||..:||
  Fly   145 EYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVFYTFVGG 209

Human   182 LKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTII 246
            :|||:.||.:||.:|.....:|.|.|.|...|::.:.:||..||||.|.|.||:|..|||.|:::
  Fly   210 IKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRHTVWSVL 274

Human   247 IGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPW 311
            |||...|||...|||:.||||:|..|..:|:.|:.|..:|:.|.::...:.||.:|..|.||||.
  Fly   275 IGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMYKDCDPL 339

Human   312 TAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFR-S 375
            :|..::..|||:|..|:..:....|:.|||:|..:...||::|..:|:.:.|.:||:::..|: .
  Fly   340 SAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVRGCFKMQ 404

Human   376 LSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSI 440
            .|||:.:.:.:...:|.|.:.:.:..:...:..:|....|:..:..|...|||.||:|||:||::
  Fly   405 PSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLVPWANTV 469

Human   441 GALVGLMAGFAISLWVGIGAQI---YPPLPERTLPLHLDIQGC--NSTYNETNLMTTTEMPFTTS 500
            |..||.:|...::.|:..|.|.   ...|..:.||  :.::||  |.|..| |:....|..|
  Fly   470 GTAVGGIASALLAGWISFGTQFTIAAGELNSQKLP--VSVEGCVGNVTLRE-NIWVDEEQVF--- 528

Human   501 VFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLST-GGRKQNLDPRYI-------LT 557
                      ||    |.|||.:.:.:|....::||.||||.| ....:.|||..|       |.
  Fly   529 ----------PL----YRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFLP 579

Human   558 KEDFLSNFDIFKKKKHVLSYKS 579
            ||.|..      :..|..::|:
  Fly   580 KECFSG------RNLHAQAHKN 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A8	NP_666018.3	SLC5sbd_SMCT1	7..549	CDD:271402	196/568 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..610
		PDZ-binding. /evidence=ECO:0000269|PubMed:30604288	608..610
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	194/560 (35%)