DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A8 and CG31262

DIOPT Version :9

Sequence 1:	NP_666018.3	Gene:	SLC5A8 / 160728	HGNCID:	19119	Length:	610	Species:	Homo sapiens
Sequence 2:	NP_001138069.2	Gene:	CG31262 / 318649	FlyBaseID:	FBgn0051262	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	182/576 - (31%)
Similarity:	295/576 - (51%)	Gaps:	71/576 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAF-----------------AGGGQQTSKDFLMG 48
            ||..| .||.   ||:|...|.::|...|||:..                 ...|.:...::|||
  Fly     1 MDNYR-FGTV---DYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMG 61

Human    49 GRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVIS--------AEVFLP 105
            .|.|..:||:::|    ....:::|||||:|.:|        |.:::::::        :.|:||
  Fly    62 SRNMKVIPVSITL----YRVTSIIGTPSEIYHYG--------TQYYLIIVAIILQGIAFSYVYLP 114

Human   106 VFYKLGITSTYEYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFD--LWGAVVA 168
            |:..|.|.|.||||.||||..:|...:.:::...:.|...::|.|||:|:||:|.:  |.|.|:.
  Fly   115 VYSALQIGSAYEYLGLRFNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVII 179

Human   169 TGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFN 233
              :.|..|..:||||||:.|||:||.:|.....:|...|:....|:..:.:||..||||...|.|
  Fly   180 --LACVTYTFMGGLKAVVHTDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTN 242

Human   234 PNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCG 298
            |:|..|||.|:::|||...|||:....|..||||:|..|..:::.:.:|..:|:...:....|.|
  Fly   243 PSPYVRHTVWSVLIGGFSFWTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIFIALCCFMG 307

Human   299 LALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAV 363
            |.|:|:|.||||.:|..:...|||:|..|:..:....|:||||:|..:...||::||..|.::.|
  Fly   308 LLLFSKYKDCDPRSAGMILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMV 372

Human   364 TVEDLIKPYFR-SLSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGL 427
            .:||:::.:|: ..|||..:.:.:...:..|.|...:..|...:..:|....|:..:..|...|:
  Fly   373 FLEDIVRGFFKMEPSERQSTILIKTCIIFQGILAFLIVFLLQHLRGILSVCNSISSITAGTSFGV 437

Human   428 FALGILVPFANSIGALVGLMAGFAISLWVGIGAQIYP---PLPERTLPLHLDIQGCNSTYNETNL 489
            |.||:|.|:||:||..||.::...::.|:..|:||..   .|....||  :.::.|      ...
  Fly   438 FTLGMLFPWANTIGTAVGGLSSVLLAGWISFGSQIAAASGQLKSGMLP--VSVKEC------VGN 494

Human   490 MTTTEMPFT--TSVFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLST 543
            :|..|.|:.  ..||.:|.            |||.:.|.:|.:..::||.||||.|
  Fly   495 VTLPEDPWVDQDQVFPLYR------------LSYHWVSPIGVVTAVVVGALVSLIT 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A8	NP_666018.3	SLC5sbd_SMCT1	7..549	CDD:271402	179/570 (31%)
SLC5A8	NP_666018.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..610
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	169/549 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146445
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850