Protein Alignment DGKB and PKC1

DIOPT Version :10

• Sequence 1: NP_001337634.1
• Gene: DGKB / 1607
• HGNCID: 2850
• Length: 804
• Species: Homo sapiens
• Sequence 2: NP_009445.2
• Gene: PKC1 / 852169
• SGDID: S000000201
• Length: 1151
• Species: Saccharomyces cerevisiae
• Alignment Length: 951
• Identity: 186/951 - (19%)
• Similarity: 304/951 - (31%)
• Gaps: 330/951 - (34%)

Human    10 LSPSEFS-QLQK-YAEYSTK--KLKDV------LEEFHGNGVLAKYNPEGKQDILNQ-------- 56
            |...||. |::| |.|.:||  ||..:      .....|..:.:||    :..:||:
Yeast   120 LQQLEFKLQVEKQYQEANTKLTKLYQIDGDQRSSSAAEGGAMESKY----RIQMLNKALKKYQAI 180

Human    57 TIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRT 121
            .:||:.||         ..|:|.       ..|:.|      |.:...|:|.|.:   .||..|.
Yeast   181 NVDFDQFK---------HQPNDI-------MDNQQP------KFRRKQLTGVLTI---GITAARD 220

Human   122 T----SPANTCSPE---VIHLKDIVCYLSLLERGRP--EDKLEFMFRLYDTDGNGFLDSSELENI 177
            .    ||.....||   .|.:.|     ::..|.:|  .|:....|::....||. ::.:..:.:
Yeast   221 VDHIQSPMFARKPESYVTIKIDD-----TIKARTKPSRNDRWSEDFQIPVEKGNE-IEITVYDKV 279

Human   178 ISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEE-W---------------------- 219
            ...::.||  :.|      .:|.::.|||.....|..:.:: |
Yeast   280 NDSLIPVA--IMW------LLLSDIAEEIRKKKAGQTNEQQGWVNASNINGGSSLASEEGSTLTS 336

Human   220 --------------IQGGMTTI---------------PLLVLLGLEN------------------ 237
                          :||..|:.               .:|:.||...
Yeast   337 TYSNSAIQSTSAKNVQGENTSTSQISTNSWFVLEPSGQILLTLGFHKSSQIERKQLMGGLHRHGA 401

Human   238 --NVKDD-----GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCI 295
              |.|::     |.|..: |.|.....|..|.:.|...|.|   |..||:..|::|.......||
Yeast   402 IINRKEEIFEQHGHHFVQ-KSFYNIMCCAYCGDFLRYTGFQ---CQDCKFLCHKKCYTNVVTKCI 462

Human   296 -KTYV-----KSKRNTDVMHHYWVEGNCPTK-CDKC--------HKTVKCYQGLTGLHCVWCQIT 345
             ||..     ::|.|..:.|.:....|..|| |..|        ||..||.:         |.|.
Yeast   463 AKTSTDTDPDEAKLNHRIPHRFLPTSNRGTKWCCHCGYILPWGRHKVRKCSE---------CGIM 518

Human   346 LHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQ------ 404
            .|.:|| ||.|:. ||...:       :...:|:|:..:..: .|:::.||...:.||.
Yeast   519 CHAQCA-HLVPDF-CGMSME-------MANKILKTIQDTKRN-QEKKKRTVPSAQLGSSIGTANG 573

Human   405 ---QPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTH---PLLVFVNPKSGGKQGERIY------- 456
               .|:|:     .:|||:        .:.|.|..|   |....|...|..||.:.|.
Yeast   574 SDLSPSKL-----AERANA--------PLPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRISLQ 625

Human   457 ----RKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPP 517
                .|....::..:.|          |||..          |...|..:           ..|.
Yeast   626 THGREKLNKFIDENEAY----------LNFTE----------GAQQTAEF-----------SSPE 659

Human   518 VAILPLGTGNDLARCLRWGGGYEGENLMKILKDI--------ENSTEIM---LDRWKF---EVIP 568
            ..:.|......|.                 |.|:        |:..::|   |:.||.   |:..
Yeast   660 KTLDPTSNRRSLG-----------------LTDLSIEHSQTWESKDDLMRDELELWKAQREEMEL 707

Human   569 NDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATC 633
            ..|.:.|:            |..|..:.|    :..:..:|.:...||.|...:.....|.:...
Yeast   708 EIKQDSGE------------IQEDLEVDH----IDLETKQKLDWENKNDFREADLTIDSTHTNPF 756

Human   634 KKLH-ESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTV 697
            :.:: |:.:||.|....::    |:....|...|.|             :.|..:::...|..|.
Yeast   757 RDMNSETFQIEQDHASKEV----LQETVSLAPTSTH-------------ASRTTDQQSPQKSQTS 804

Human   698 TDAKELKFASQDLSDQLLEVVGLE--GAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDG 760
            |.||..|.|::.....|...|.|:  |....|::.........||  |:..|:: ..::....|.
Yeast   805 TSAKHKKRAAKRRKVSLDNFVLLKVLGKGNFGKVILSKSKNTDRL--CAIKVLK-KDNIIQNHDI 866

Human   761 EPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLVKRTRNR 801
            |..........:..|.:.|.|      |.|:||.  :|.||
Yeast   867 ESARAEKKVFLLATKTKHPFL------TNLYCSF--QTENR 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DGKB	NP_001337634.1	DAG_kinase_N	6..149	CDD:464196	38/163 (23%)
		EFh	153..222	CDD:238008	12/105 (11%)
		C1_DGKbeta_rpt1	238..303	CDD:410395	20/75 (27%)
		C1_DGKbeta_rpt2	308..366	CDD:410441	20/66 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..406		5/29 (17%)
		DAGKc	440..561	CDD:214487	20/142 (14%)
		DAGKa	582..762	CDD:214486	34/182 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..694		1/20 (5%)
		Required for association with membranes and function in neurite spine formation. /evidence=ECO:0000305|PubMed:11719522	771..804		10/31 (32%)
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011
		HR1_PKC-like_2_fungi	110..181	CDD:212010	16/64 (25%)
		C2_fungal_Pkc1p	211..319	CDD:176071	25/124 (20%)
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	16/54 (30%)
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	20/68 (29%)
		STKc_PKC	828..1145	CDD:270722	18/83 (22%)