Protein Alignment DGKB and Dgkb

DIOPT Version :10

• Sequence 1: NP_001337634.1
• Gene: DGKB / 1607
• HGNCID: 2850
• Length: 804
• Species: Homo sapiens
• Sequence 2: XP_008762871.2
• Gene: Dgkb / 54248
• RGDID: 2488
• Length: 803
• Species: Rattus norvegicus
• Alignment Length: 804
• Identity: 777/804 - (96%)
• Similarity: 790/804 - (98%)
• Gaps: 1/804 - (0%)

Human     1 MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKL 65

Human    66 FMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTCSP 130
            |||||||||||||||||||||||||||||||.||||||||||||||||||||||| :||||||||
  Rat    66 FMKTFLEAELPDDFTAHLFMSFSNKFPHSSPNVKSKPALLSGGLRMNKGAITPPR-SSPANTCSP 129

Human   131 EVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTEL 195
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
  Rat   130 EVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIIGQMMHVAEYLEWDVTEL 194

Human   196 NPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNL 260
            ||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   195 NPILHEMMEEIDYDRDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNL 259

Human   261 CLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCH 325
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
  Rat   260 CLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKKNTDVMHHYWVEGNCPTKCDKCH 324

Human   326 KTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPE 390
            ||||||||||||||||||.||||||||||||||||||||||||||||||||||||:||:|.||||
  Rat   325 KTVKCYQGLTGLHCVWCQTTLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTMPTAGTSVPE 389

Human   391 ERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERI 455
            |||||.||||..|||||||.||||||||||||:||||||:||:||||||||||||||||||||||
  Rat   390 ERQSTAKKEKGSSQQPNKVTDKNKMQRANSVTMDGQGLQITPIPGTHPLLVFVNPKSGGKQGERI 454

Human   456 YRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAI 520
            |||||||||||||||||||||||||:|||||||||||||||||||||:|||||||||.|||||||
  Rat   455 YRKFQYLLNPRQVYSLSGNGPMPGLHFFRDVPDFRVLACGGDGTVGWILDCIEKANVVKHPPVAI 519

Human   521 LPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINN 585
            ||||||||||||||||||||||||||||||||:|||||||||||||.||||||||||||||||||
  Rat   520 LPLGTGNDLARCLRWGGGYEGENLMKILKDIESSTEIMLDRWKFEVTPNDKDEKGDPVPYSIINN 584

Human   586 YFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQID 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   585 YFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQID 649

Human   651 LINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLL 715
            |||||||||||||||||||||||||||||:||||||||||||||.|:||||||||||||||||||
  Rat   650 LINISLEGIAILNIPSMHGGSNLWGESKKKRSHRRIEKKGSDKRPTLTDAKELKFASQDLSDQLL 714

Human   716 EVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPM 780
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
  Rat   715 EVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPM 779

Human   781 LMGPPPKTGLFCSLVKRTRNRSKE 804
            ||||||||||||||:|||||||||
  Rat   780 LMGPPPKTGLFCSLIKRTRNRSKE 803

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DGKB	NP_001337634.1	DAG_kinase_N	6..149	CDD:464196	139/142 (98%)
		EFh	153..222	CDD:238008	66/68 (97%)
		C1_DGKbeta_rpt1	238..303	CDD:410395	64/64 (100%)
		C1_DGKbeta_rpt2	308..366	CDD:410441	56/57 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..406		16/20 (80%)
		DAGKc	440..561	CDD:214487	116/120 (97%)
		DAGKa	582..762	CDD:214486	175/179 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..694		19/20 (95%)
		Required for association with membranes and function in neurite spine formation. /evidence=ECO:0000305|PubMed:11719522	771..804		31/32 (97%)
Dgkb	XP_008762871.2	DAG_kinase_N	6..148	CDD:464196	139/142 (98%)
		EFh	152..221	CDD:238008	66/68 (97%)
		C1_DGKbeta_rpt1	237..302	CDD:410395	64/64 (100%)
		C1_DGKbeta_rpt2	307..365	CDD:410441	56/57 (98%)
		DAGKc	439..560	CDD:214487	116/120 (97%)
		DAGKa	581..761	CDD:214486	175/179 (98%)