Protein Alignment DGKB and Dgk

DIOPT Version :10

• Sequence 1: NP_001337634.1
• Gene: DGKB / 1607
• HGNCID: 2850
• Length: 804
• Species: Homo sapiens
• Sequence 2: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Alignment Length: 1270
• Identity: 459/1270 - (36%)
• Similarity: 571/1270 - (44%)
• Gaps: 530/1270 - (41%)

Human     6 KWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLA--KYNPEGKQDILNQTIDFEGFKLFMK 68
            ||..|||.||.|||:.|.|||:||:|||.||......:  |..|:|       .|||:||:.|:.
  Fly     9 KWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDG-------DIDFDGFRRFLD 66

Human    69 TFLEAELPDDFTAHLFMSF---------------------------------------------- 87
            .||:.|.|.|...|||:||
  Fly    67 AFLDCEAPLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAE 131

Human    88 --------------------------------------SNKFPHS---------------SPMVK 99
                                                  ::|..||               .||:.
  Fly   132 LMPQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLT 196

Human   100 SKPALLSGGLRMNKGAITPPR---TTSPANTCS----------------------------PEV- 132
            ..|:.|:.|..|.: |..|.|   .:||:::.:                            |.:
  Fly   197 VTPSPLASGPSMFQ-ASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIG 260

Human   133 ------------------------------------IHLKDIVCYLSLLERGRPEDKLEFMFRLY 161
                                                :.|||:||||||||.||||||||||||||
  Fly   261 RHCPGSLESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLY 325

Human   162 DTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTT 226
            |||.||.||::|::.|::|||.|||||.|||:||.|||.|||.|||||.||||||:||.:|||||
  Fly   326 DTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTT 390

Human   227 IPLLVLLGLEN-NVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARA 290
            ||||||||::: .:|:||.||||||||:||||||||||||:|:||:||||..||||||||||..|
  Fly   391 IPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHA 455

Human   291 PPSCIKTYVKSKR---NTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCAS 352
            |.|||.||||||:   ..|::|| ||||||..:|.||.|.:|.|.|:|||.|.||.:.|||:|||
  Fly   456 PASCITTYVKSKKPKCGGDLLHH-WVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCAS 519

Human   353 HLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQR 417
            .:|.||..|...:.|:|||.|||.||            :||.:|                |:..:
  Fly   520 SVKKECTLGEYSELIVPPTAICPAVL------------DRQRSV----------------NQAHK 556

Human   418 ANSVTVDGQGLQVTPVPG--THPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL 480
            |..       .|:|| |.  :.||||||||||||:||:||.|||||:|||||||.||..||..||
  Fly   557 ATH-------FQITP-PDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGL 613

Human   481 NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLM 545
            ..|:|:|.|||:.|||||||||||:.::...:...|.:.::||||||||||||||||||||||:.
  Fly   614 TLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIP 678

Human   546 KILKDIENSTEIMLDRWKFEV--IPNDKD------------------------------------ 572
            |::.....::.:|||||..||  .|:..|
  Fly   679 KLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQR 743

Human   573 ----------------------------------------------------------------- 572
                                                                             
  Fly   744 QSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQT 808

Human   573 ---------------------------------------EKGDP--------------------- 577
                                                   ||..|
  Fly   809 LRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQ 873

Human   578 ----------------------------------------------------------------- 577
                                                                             
  Fly   874 MQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDG 938

Human   578 ------------------------------------------------------------VPYSI 582
                                                                        |||:|
  Fly   939 GGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNI 1003

Human   583 INNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGV 647
            ||||||:||||:|..:||:.|||:|.|||||||||.||||:.|||||:|:||.||||:||.||||
  Fly  1004 INNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGV 1068

Human   648 QIDLIN-ISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEK-----------KGSDKRTTVT-- 698
            .:||.| ..|:|:|:||||..|||||||||   ..|.:||.|           :..||..:.|
  Fly  1069 ALDLANGPHLQGVALLNIPYTHGGSNLWGE---HLSQKRIRKSAGPFGKSKKLRAGDKEFSATSF 1130

Human   699 DAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPW 763
            ::.:|..|.||..|:|:||:|||..:.|||:.|||:::||||||||.|:|:|.|:.|||||||||
  Fly  1131 NSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPW 1195

Human   764 MQTPCTIKITHKNQAPMLMGPPPKTG-----LFCS 793
            ||.|||||:|||||.||||.|..:.|     |.||
  Fly  1196 MQMPCTIKVTHKNQVPMLMAPRSEKGRGFFNLLCS 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DGKB	NP_001337634.1	DAG_kinase_N	6..149	CDD:464196	66/311 (21%)
		EFh	153..222	CDD:238008	50/68 (74%)
		C1_DGKbeta_rpt1	238..303	CDD:410395	50/64 (78%)
		C1_DGKbeta_rpt2	308..366	CDD:410441	31/57 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..406		3/20 (15%)
		DAGKc	440..561	CDD:214487	75/120 (63%)
		DAGKa	582..762	CDD:214486	110/193 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..694		9/31 (29%)
		Required for association with membranes and function in neurite spine formation. /evidence=ECO:0000305|PubMed:11719522	771..804		15/28 (54%)
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	40/114 (35%)
		EFh	317..386	CDD:238008	50/68 (74%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	50/64 (78%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	30/51 (59%)
		DAGKc	573..694	CDD:214487	75/120 (63%)
		DAGKa	1003..1194	CDD:214486	110/193 (57%)