Protein Alignment DGKB and dgk-3

DIOPT Version :10

• Sequence 1: NP_001337634.1
• Gene: DGKB / 1607
• HGNCID: 2850
• Length: 804
• Species: Homo sapiens
• Sequence 2: NP_499031.3
• Gene: dgk-3 / 186262
• WormBaseID: WBGene00000960
• Length: 795
• Species: Caenorhabditis elegans
• Alignment Length: 833
• Identity: 417/833 - (50%)
• Similarity: 526/833 - (63%)
• Gaps: 92/833 - (11%)

Human    10 LSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAE 74
            |||.:||:|.:||.||.:||||:|.:|..:|....|     ..:..|||:.:||:.|:..:..|:
 Worm     3 LSPEQFSRLSEYAAYSRRKLKDMLSDFQQDGKFYSY-----LSVDGQTINIDGFRAFLIDYFGAD 62

Human    75 LPDDFTAHLFMSFS---------NKFPHSSPMVKSK-PALLSG---GLRMNKGA---ITPPRTTS 123
            ||.|....||:|||         :.|..:...|::| ...|||   ||.:..|:   ....:::.
 Worm    63 LPSDLVDQLFLSFSKPPIKERRTSLFEDAISTVRAKFSESLSGRMAGLNIAGGSGQQTDRSQSSE 127

Human   124 P-ANTCSPE----------------VIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDS 171
            | |..|.||                .|.||.::|.|||||...||:||:.:|.:||:|||||||.
 Worm   128 PQALVCIPEDDVMGPRVANNDSQEPRIPLKPLICTLSLLEADTPENKLDVVFHVYDSDGNGFLDK 192

Human   172 SELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLE 236
            ||::.||.|||:||.|.:||..||..::.:||.:||||:||.||.:||.:||:|.||||||||.:
 Worm   193 SEIDGIIEQMMNVARYQQWDTIELEQVIRQMMVDIDYDNDGIVSFDEWRRGGLTNIPLLVLLGFD 257

Human   237 NNVKDDGQHVWRLKHFNKPAYCNLCLNMLIG-VGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK 300
            ..:|:||.|||||:||.||.|||.|.::|:| .|||||.||.||||||||||..|..:||:||
 Worm   258 TEMKEDGSHVWRLRHFTKPTYCNACCSILVGWGGKQGLSCSLCKYTVHERCVRSAATNCIRTY-- 320

Human   301 SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKD 365
            |.|..|.::|:|.:.|...||.||..||..:|   |..|.||...:|::|.|.|..|||.|.|..
 Worm   321 SSRQQDKLYHHWQDANATAKCVKCKATVGVFQ---GKGCRWCHNYVHHRCMSALAQECDLGALVH 382

Human   366 HILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQV 430
            ||||||.|.|..|           |.:.||..|..:.|.....::.                 .|
 Worm   383 HILPPTHIFPAFL-----------ERKTSTSLKNHNFSSHSASLLQ-----------------AV 419

Human   431 TPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACG 495
            :|.....||||.||||||||||.:|.:||:|||||||||.||..||.|||..|..:.:..:|.||
 Worm   420 SPSNDCRPLLVLVNPKSGGKQGVKILQKFEYLLNPRQVYDLSKTGPEPGLQLFSTLKNCNILVCG 484

Human   496 GDGTVGWVLDCIEKANV--GKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIM 558
            ||||:||||:.::|...  |: ||||:||||||||||||||||||||.|||.|||:.||.|:.|.
 Worm   485 GDGTIGWVLESMDKMTFPHGR-PPVAVLPLGTGNDLARCLRWGGGYENENLHKILEQIEKSSLID 548

Human   559 LDRW--KFEVIPNDK----DEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNK 617
            :|||  |.|:..|..    .||||..||||||||||||||||||||||:||||.||||||||:||
 Worm   549 MDRWQIKIEITENKSARRASEKGDTPPYSIINNYFSIGVDASIAHRFHVMREKFPEKFNSRMRNK 613

Human   618 FWYFEFGTSETFSATCKKLHESVEIECDGVQIDL-INISLEGIAILNIPSMHGGSNLWGESKKRR 681
            .||||.|||||.|::||.|||.::|.|||..||| .:.||||||:|||||::|||||||.|:|.:
 Worm   614 LWYFELGTSETLSSSCKNLHEQIDILCDGESIDLGQDASLEGIALLNIPSIYGGSNLWGRSRKSK 678

Human   682 SHR--RIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCS 744
            ...  ....|.::|       .:|:...||:.|.|:|:||||.||:||||..|::.| |||:|||
 Worm   679 GRMPGLFPMKNAEK-------MQLQTRVQDIGDGLIELVGLESAMQMGQIKAGVRGA-RRLSQCS 735

Human   745 CVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLVKR 797
            .|||:|.||.|||||||||||.||.|:|||||||.||:...|:......|:||
 Worm   736 TVVIQTHKSFPMQIDGEPWMQPPCIIQITHKNQAKMLVAAAPRKRSSWMLLKR 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DGKB	NP_001337634.1	DAG_kinase_N	6..149	CDD:464196	56/171 (33%)
		EFh	153..222	CDD:238008	38/68 (56%)
		C1_DGKbeta_rpt1	238..303	CDD:410395	41/65 (63%)
		C1_DGKbeta_rpt2	308..366	CDD:410441	23/57 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..406		5/20 (25%)
		DAGKc	440..561	CDD:214487	79/122 (65%)
		DAGKa	582..762	CDD:214486	113/182 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..694		6/22 (27%)
		Required for association with membranes and function in neurite spine formation. /evidence=ECO:0000305|PubMed:11719522	771..804		13/27 (48%)
dgk-3	NP_499031.3	DAG_kinase_N	2..170	CDD:464196	56/171 (33%)
		EFh	174..243	CDD:238008	38/68 (56%)
		C1_DGK_typeI_rpt1	261..323	CDD:410349	41/63 (65%)
		C1_DGK_typeI_like_rpt2	330..378	CDD:410401	21/50 (42%)
		DAGKc	429..551	CDD:214487	79/122 (65%)
		DAGKa	578..753	CDD:214486	113/182 (62%)