DRSC/TRiP Functional Genomics Resources

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Protein Alignment DGKA and CG31140

DIOPT Version :10

Sequence 1:XP_016874389.1 Gene:DGKA / 1606 HGNCID:2849 Length:891 Species:Homo sapiens
Sequence 2:NP_001262893.1 Gene:CG31140 / 42836 FlyBaseID:FBgn0051140 Length:1571 Species:Drosophila melanogaster


Alignment Length:420 Identity:146/420 - (34%)
Similarity:218/420 - (51%) Gaps:75/420 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   491 YPSVLASGPD-----RKNSKTSQKTMDDLNLSTSEALRIDP--VP-NTHPLLVFVNPKSGGKQGQ 547
            |.||:.:..|     |......:..::|..|.......|:|  || :..|||||||.||||.||.
  Fly  1070 YGSVVLTFEDSMKAVRAFYNLRETIIEDKKLLVLLLPNIEPSMVPSDVRPLLVFVNVKSGGCQGL 1134

Human   548 RVLWKFQYILNPRQVFNLLKDGP--------------------EIGLRLFKDVPDSRILVCGGDG 592
            .::..|:.:|||.|||:|...||                    .|.|.:|:.:.:.:||||||||
  Fly  1135 ELISSFRKLLNPYQVFDLDNGGPLPGYVQPITVFVIRPLIFDSIISLYVFRQITNYKILVCGGDG 1199

Human   593 TVGWILETIDKANLP---VLPPVAVLPLGTGNDLARCLRWGGGYE-GQNLAKILKDLEMSKVVHM 653
            |:||:|:.:|.....   ..||.|::||||||||||.|.||.||. |::...:|:|:..::.:.:
  Fly  1200 TIGWVLQCLDNVGQDSECSSPPCAIVPLGTGNDLARVLCWGSGYTGGEDPLNLLRDVIEAEEIRL 1264

Human   654 DRWSVEVIPQ-QTEEKSDPVPFQ--------------IINNYFSIGVDASIAHRFHIMREKYPEK 703
            |||:|...|: :.||.:...|.|              ::||||.||:||.:...||..||:.|.:
  Fly  1265 DRWTVVFHPEDKPEEPAMKAPSQTTGGAQNEDNSQIFVMNNYFGIGIDADLCLDFHNAREENPNQ 1329

Human   704 FNSRMKNKLWYFEFATSESI-FSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNL 767
            ||||::||.:|.:....:.: ....|.|::.|.:|:.||.::|.  .::||.:|||.|...|:|.
  Fly  1330 FNSRLRNKGYYVKMGLRKIVGRKAVKDLQKELRLEVDGKIVELP--PVDGIIILNILSWGSGANP 1392

Human   768 WGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAG 832
            ||    |..|                  |...|  |:..|..|||||:.|.:.:|||.:.::.| 
  Fly  1393 WG----PDKD------------------DQFST--PNHYDGMLEVVGVTGVVHLGQIQSGIRTA- 1432

Human   833 RRLAKCSEITFHTTKTLPMQIDGEPWMQTP 862
            .|:|:...|..|....:|:|:|||||:|:|
  Fly  1433 MRIAQGGHIKIHLNTDMPVQVDGEPWIQSP 1462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DGKAXP_016874389.1 DAG_kinase_N 42..148 CDD:464196
EFh <298..339 CDD:415501
C1_DGK_typeI_rpt1 357..417 CDD:410349
C1_DGKalpha_rpt2 426..487 CDD:410440
DAGKc 534..655 CDD:214487 58/144 (40%)
DAGKa 676..857 CDD:214486 61/181 (34%)
CG31140NP_001262893.1 C1_DGKtheta_typeV_rpt1 5..60 CDD:410353
C1_DGKtheta_typeV_rpt2 64..120 CDD:410354
C1_DGKtheta_typeV_rpt3 135..197 CDD:410404
RA1_DAGK-theta 833..922 CDD:340631
RA2_DAGK-theta 925..1022 CDD:340481
DAGKc 1121..1266 CDD:214487 58/144 (40%)
DAGK_acc 1302..1457 CDD:459866 61/181 (34%)
Blue background indicates that the domain is not in the aligned region.

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