Protein Alignment DGKA and Dgk

DIOPT Version :10

• Sequence 1: XP_016874389.1
• Gene: DGKA / 1606
• HGNCID: 2849
• Length: 891
• Species: Homo sapiens
• Sequence 2: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Alignment Length: 1348
• Identity: 395/1348 - (29%)
• Similarity: 505/1348 - (37%)
• Gaps: 635/1348 - (47%)

Human    46 ISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMA---KYVQGDAIGYEGFQQFLKIYLEVDNVPRH 107
            :||.:|.|||:...|||:|:.|||:.|.....|   |.:....|.::||::||..:|:.: .|..
  Fly    13 LSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFDGFRRFLDAFLDCE-APLD 76

Human   108 LSLALFQSF----------------------ETGHCLNETNVTK--------------------- 129
            |:..||.||                      .|..|...|:.||
  Fly    77 LAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAELMPQCSGGGG 141

Human   130 ----------------------------------------------------------------- 129
                                                                             
  Fly   142 GIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLTVTPSPLASGP 206

Human   130 ----------------------------------------------------------------- 129
                                                                             
  Fly   207 SMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGRHCPGSLESGS 271

Human   130 -------DV----------------VCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSS 171
                   |:                |.|.||.||.||||.|||||||||.|:|||||.||:||::
  Fly   272 AQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDSNGVLDTA 336

Human   172 VSWGPCMLGKGICVNLSAPSCPNSSRVLRNRRGWGERLSPLGLNLKVSPKLLTPQRECWIHELGL 236
                                                                             
  Fly   337 ----------------------------------------------------------------- 336

Human   237 PYKHTNTFIYLADIPENERCESGVEPRNTDFWKRVWMVVVKGIWLWLLPFLLQEVDKIILQMMRV 301
                                                                 |:|.|:.|||.|
  Fly   337 -----------------------------------------------------EMDAIVNQMMAV 348

Human   302 AEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLE-MTLKDDGQHMWR 365
            ||||.||||||||||||||.|||||..|:||..||.|.|.||:|||||||:: .|||:||.|:||
  Fly   349 AEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKEDGIHVWR 413

Human   366 PKRFPRPVYCNLC-ESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDI--GVQSHV 427
            .|.|.:|.||||| ...:||||:||.|.|||||||::|...|....::||.||:|..  |...|.
  Fly   414 LKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLLHH 478

Human   428 WVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYP 492
            ||.|.| .|||.:|:|:|:.||.:|||.|.|||:.:|:.|..:|..||..|...:.|:||::|.|
  Fly   479 WVEGNC-YGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAICP 542

Human   493 SVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYIL 557
            :||    ||:.|...........::..:.|       :.||||||||||||:||.|:|.||||:|
  Fly   543 AVL----DRQRSVNQAHKATHFQITPPDEL-------SCPLLVFVNPKSGGRQGDRILRKFQYML 596

Human   558 NPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGND 622
            |||||::|.|.||:.||.||||:|..|::.|||||||||:||.:|...|...|.:.|:|||||||
  Fly   597 NPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGND 661

Human   623 LARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP------------------------- 662
            |||||||||||||:|:.|::.....:..|.:||||:||..
  Fly   662 LARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQ 726

Human   663 ----------------------------------------------------------------- 662
                                                                             
  Fly   727 SVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTT 791

Human   663 --------------QQT--------------------------------------EEKSDP---- 671
                          |||                                      .|||.|
  Fly   792 TKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSG 856

Human   672 ----------------------------------------------------------------- 671
                                                                             
  Fly   857 ETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQI 921

Human   672 ----------------------------------------------------------------- 671
                                                                             
  Fly   922 TLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQ 986

Human   672 ------------VPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIF 724
                        ||:.|||||||:||||:|..:||:.|||.|.||||||||||||||:||||:..
  Fly   987 KPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFA 1051

Human   725 STCKKLEESLTVEICGKPLDLSN-LSLEGIAVLNIPSMHGGSNLWGD------TRRPHGDIYGIN 782
            ::||.|.||:.:...|..|||:| ..|:|:|:||||..||||||||:      .|:..|. :|.:
  Fly  1052 ASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGP-FGKS 1115

Human   783 QALGATAKVITDPDI----LKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITF 843
            :.|.|..|..:....    |...:.|..|:.:||:|||..:.|||:.|.|:.:|||||:|||:..
  Fly  1116 KKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVII 1180

Human   844 HTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGP-PPRSTNFFGFL 890
            .|.||.|||||||||||.|||||:|||||:||||.| ..:...||..|
  Fly  1181 KTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGRGFFNLL 1228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DGKA	XP_016874389.1	DAG_kinase_N	42..148	CDD:464196	44/300 (15%)
		EFh	<298..339	CDD:415501	31/40 (78%)
		C1_DGK_typeI_rpt1	357..417	CDD:410349	32/60 (53%)
		C1_DGKalpha_rpt2	426..487	CDD:410440	27/60 (45%)
		DAGKc	534..655	CDD:214487	74/120 (62%)
		DAGKa	676..857	CDD:214486	97/191 (51%)
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	30/104 (29%)
		EFh	317..386	CDD:238008	49/186 (26%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	36/64 (56%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	25/51 (49%)
		DAGKc	573..694	CDD:214487	74/120 (62%)
		DAGKa	1003..1194	CDD:214486	97/191 (51%)