Protein Alignment DAG1 and dag1

DIOPT Version :10

• Sequence 1: NP_004384.5
• Gene: DAG1 / 1605
• HGNCID: 2666
• Length: 895
• Species: Homo sapiens
• Sequence 2: NP_775381.2
• Gene: dag1 / 286829
• ZFINID: ZDB-GENE-021223-1
• Length: 862
• Species: Danio rerio
• Alignment Length: 900
• Identity: 544/900 - (60%)
• Similarity: 655/900 - (72%)
• Gaps: 67/900 - (7%)

Human    12 PLSG---RTFLLL-----LSVVMAQSHWPSEPSEAVRDWENQLEASMHS-VLSDLH--EAVPTVV 65
            |:.|   ||.::|     |:|...::.|  :..|.:.|  .:||||||| ||||:.  |||....
Zfish    14 PMLGQWDRTLVVLLMALALTVTDVRASW--DQMEVLGD--VKLEASMHSAVLSDIREAEAVSQPS 74

Human    66 GIPDGTAVVGRSFRVTIPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTLEGLPLDTDKGVHY 130
            |.||.:|||||.||:.:|.. ...||.|:|::.|.|:.||:|||||::|.||:||||:|||||||
Zfish    75 GFPDSSAVVGRVFRLQVPIK-AKDSGSIVKITEASKDVLPAWLHWDAESGTLQGLPLETDKGVHY 138

Human   131 ISVSATRLGANGSHIPQTSSVFSIEVYPEDHSE-----LQSVRTASPDPGEVVSSACAADEPVTV 190
            ||||.    :|.|.:.|:..||||||:||:|:|     |...::||.|....:   |..:|||||
Zfish   139 ISVSV----SNESKVSQSPDVFSIEVHPEEHAETDPFQLAIQQSASNDAQPFI---CGNEEPVTV 196

Human   191 LTVILDADLTKMTPKQRIDLLHRMRSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENG 255
            ||||||||||||:.|||::||.:|:.||.:.|.:||::|||||||||||||||||||||||||||
Zfish   197 LTVILDADLTKMSSKQRVELLAKMKKFSGMGLQHMKILPVVNNRLFDMSAFMAGPGNAKKVVENG 261

Human   256 ALLSWKLGCSLNQNSVPDIHGVEAPAREGAMSAQLGYPVVGWHIANKKPPLPKRVRRQIHATPTP 320
            |||||||||||:|:|:|||..|:.||:||.|||||||||||||||||||.:|||||||::.||||
Zfish   262 ALLSWKLGCSLDQSSIPDISSVQVPAKEGTMSAQLGYPVVGWHIANKKPHVPKRVRRQLNNTPTP 326

Human   321 VTAIGPPTTAIQEPPSRIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPI 385
            :.::.|||| ..|||.|||||||||:|||.:|:.|||||.|||.....|||.|.:...||||||.
Zfish   327 IPSLLPPTT-YPEPPIRIVPTPTSPSIAPTSESSAPPVRGPVPLPVKPTIRNRDSAPSTPTLGPP 390

Human   386 QPTRVSEAGTTVPGQIRPTMTIPGYVEPTAVATPPTTTTKKPRVSTPKPATPSTDSTTTTTRRPT 450
            .||||....:|:  .|:||:|.|.||  .|..||.|.||:||                  |:||.
Zfish   391 LPTRVMVTTSTI--AIQPTVTRPVYV--GASVTPATPTTRKP------------------TKRPP 433

Human   451 KKPRTPRPVPRVTTKVSITRLETASPPTRIRTTTSGVPRGGEPNQRPELKNHIDRVDAWVGTYFE 515
            |||:| .|:||.      .:..|..||   |.:|..|.  |:.|.:|||:|.||:|:|:||||||
Zfish   434 KKPKT-TPIPRE------PKTTTTKPP---RRSTPAVI--GDSNIKPELRNPIDQVNAYVGTYFE 486

Human   516 VKIPSDTFYDHEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHAT 580
            ||:|||||:|.||.|||||:|||: :...:|.:.||:||||.|||:|||||..|.|||||||.||
Zfish   487 VKVPSDTFFDKEDGTTDKLRLTLR-KGNDVVADDSWIQFNSTSQLLYGLPDQEHAGKHEYFMQAT 550

Human   581 DKGGLSAVDAFEIHVHRRPQGDRAPARFKAKFVGDPALVLNDIHKKIALVKKLAFAFGDRNCSTI 645
            |||||.|:||||:.|.......:.|..|.|.|.||...|.|||||||.|||||:.:|||||.|||
Zfish   551 DKGGLYAMDAFEVRVSMWGNSVKPPVLFTAVFDGDARTVTNDIHKKILLVKKLSQSFGDRNSSTI 615

Human   646 TLQNITRGSIVVEWTNNTLPLEPCPKEQIAGLSRRIAEDDGKPRPAFSNALEPDFKATSITVTGS 710
            ||::||:|||:||||||:|...||||:||..||::|::.:|||...|...:||||:.::|||.|:
Zfish   616 TLKSITKGSIIVEWTNNSLQQSPCPKDQIQQLSKKISDPEGKPSSIFKFTMEPDFRPSNITVRGT 680

Human   711 GSCRHLQFIPVVPPRRVPSEAPPTEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICY 775
            .|||:..|:|:   ..:|...|....|.....:.|.|||||||||||||||||||||||||||||
Zfish   681 ASCRNYMFVPL---GEIPDPTPSPVTPSVGAGRQSTDDVYLHTVIPAVVVAAILLIAGIIAMICY 742

Human   776 RKKRKGKLTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETT 840
            |||||||||:||||||||||||||||||||||||||||||||||||||.|||||||||.:.||||
Zfish   743 RKKRKGKLTIEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKPPLPPPEYPNMASPETT 807

Human   841 PLNQDTMGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP 895
            |||||.:||||||.|||||||||||||||:.||||||||||||||||||||||||
Zfish   808 PLNQDLLGEYTPLHDEDPNAPPYQPPPPFSTPMEGKGSRPKNMTPYRSPPPYVPP 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAG1	NP_004384.5	Required for laminin recognition	30..408		230/385 (60%)
		Dystroglycan_repeat	62..163	CDD:206636	54/100 (54%)
		O-glycosylated at one site	169..200		17/30 (57%)
		a_DG1_N2	182..304	CDD:465761	94/121 (78%)
		PRK12323	<303..>404	CDD:481241	57/100 (57%)
		Mucin-like domain	316..485		76/168 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..460		32/78 (41%)
		O-glycosylated at seven sites with GalNAc	463..485		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..498		5/19 (26%)
		Dystroglycan_repeat	498..602	CDD:206636	67/103 (65%)
		DAG1	606..895	CDD:461655	207/288 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..746		3/21 (14%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:20512930	776..782		5/5 (100%)
		Required for interaction with CAV3. /evidence=ECO:0000269|PubMed:10988290	819..895		66/75 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	823..895		62/71 (87%)
		Required for binding DMD and UTRN	880..895		14/14 (100%)
		PPXY motif	889..892		2/2 (100%)
dag1	NP_775381.2	None