Protein Alignment DAG1 and Dag1

DIOPT Version :10

• Sequence 1: NP_004384.5
• Gene: DAG1 / 1605
• HGNCID: 2666
• Length: 895
• Species: Homo sapiens
• Sequence 2: NP_446149.1
• Gene: Dag1 / 114489
• RGDID: 621890
• Length: 893
• Species: Rattus norvegicus
• Alignment Length: 893
• Identity: 829/893 - (92%)
• Similarity: 853/893 - (95%)
• Gaps: 0/893 - (0%)

Human     3 MSVGLSLLLPLSGRTFLLLLSVVMAQSHWPSEPSEAVRDWENQLEASMHSVLSDLHEAVPTVVGI 67
            |||...||.||.|:||||||||.:||:|||||||||||||:|||||||||||||..|||||||||
  Rat     1 MSVDNWLLHPLWGQTFLLLLSVAVAQAHWPSEPSEAVRDWKNQLEASMHSVLSDFQEAVPTVVGI 65

Human    68 PDGTAVVGRSFRVTIPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTLEGLPLDTDKGVHYIS 132
            |||||||||||||:||||||||||:|||||||||||||||||||..||.||||||||||||||||
  Rat    66 PDGTAVVGRSFRVSIPTDLIASSGEIIKVSAAGKEALPSWLHWDPHSHILEGLPLDTDKGVHYIS 130

Human   133 VSATRLGANGSHIPQTSSVFSIEVYPEDHSELQSVRTASPDPGEVVSSACAADEPVTVLTVILDA 197
            |||.||||||||:|||:||||||||||||||.||||.||.|||||||||||||||||||||||||
  Rat   131 VSAARLGANGSHVPQTASVFSIEVYPEDHSEPQSVRAASSDPGEVVSSACAADEPVTVLTVILDA 195

Human   198 DLTKMTPKQRIDLLHRMRSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKL 262
            ||||||||||||||:||:|||||||:|||||||||||||||||||||||||||||||||||||||
  Rat   196 DLTKMTPKQRIDLLNRMQSFSEVELNNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKL 260

Human   263 GCSLNQNSVPDIHGVEAPAREGAMSAQLGYPVVGWHIANKKPPLPKRVRRQIHATPTPVTAIGPP 327
            ||||||||||||.|||.|||||.|||.|||||||||||||||.||||:|||||||||||||||||
  Rat   261 GCSLNQNSVPDIRGVETPAREGTMSAHLGYPVVGWHIANKKPTLPKRIRRQIHATPTPVTAIGPP 325

Human   328 TTAIQEPPSRIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIQPTRVSE 392
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||
  Rat   326 TTAIQEPPSRIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIPPTRVSE 390

Human   393 AGTTVPGQIRPTMTIPGYVEPTAVATPPTTTTKKPRVSTPKPATPSTDSTTTTTRRPTKKPRTPR 457
            ||||||||||||:|||||||||||.||||||||||||||||||||||||:|||||||||||||||
  Rat   391 AGTTVPGQIRPTLTIPGYVEPTAVVTPPTTTTKKPRVSTPKPATPSTDSSTTTTRRPTKKPRTPR 455

Human   458 PVPRVTTKVSITRLETASPPTRIRTTTSGVPRGGEPNQRPELKNHIDRVDAWVGTYFEVKIPSDT 522
            ||||||||..||||||||||||||||||.||||||.|||||||||||||||||||||||||||||
  Rat   456 PVPRVTTKAPITRLETASPPTRIRTTTSAVPRGGEANQRPELKNHIDRVDAWVGTYFEVKIPSDT 520

Human   523 FYDHEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGGLSA 587
            |||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 FYDNEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGGLSA 585

Human   588 VDAFEIHVHRRPQGDRAPARFKAKFVGDPALVLNDIHKKIALVKKLAFAFGDRNCSTITLQNITR 652
            |||||||||:|||||:||||||||..||||.|:|||||||||||||||||||||||:||||||||
  Rat   586 VDAFEIHVHKRPQGDKAPARFKAKLAGDPAPVVNDIHKKIALVKKLAFAFGDRNCSSITLQNITR 650

Human   653 GSIVVEWTNNTLPLEPCPKEQIAGLSRRIAEDDGKPRPAFSNALEPDFKATSITVTGSGSCRHLQ 717
            ||||||||||||||||||||||.|||||||:::|||||||||||||||||.|:.|.|||||||||
  Rat   651 GSIVVEWTNNTLPLEPCPKEQIVGLSRRIADENGKPRPAFSNALEPDFKALSVAVAGSGSCRHLQ 715

Human   718 FIPVVPPRRVPSEAPPTEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGK 782
            ||||.||....|.||.|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   716 FIPVAPPSPGTSAAPATEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGK 780

Human   783 LTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETTPLNQDTM 847
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
  Rat   781 LTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETTPLNQDTV 845

Human   848 GEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP 895
            ||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   846 GEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAG1	NP_004384.5	Required for laminin recognition	30..408		352/377 (93%)
		Dystroglycan_repeat	62..163	CDD:206636	92/100 (92%)
		O-glycosylated at one site	169..200		28/30 (93%)
		a_DG1_N2	182..304	CDD:465761	114/121 (94%)
		PRK12323	<303..>404	CDD:481241	97/100 (97%)
		Mucin-like domain	316..485		162/168 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..460		74/78 (95%)
		O-glycosylated at seven sites with GalNAc	463..485		19/21 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..498		17/19 (89%)
		Dystroglycan_repeat	498..602	CDD:206636	101/103 (98%)
		DAG1	606..895	CDD:461655	267/288 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..746		15/21 (71%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:20512930	776..782		5/5 (100%)
		Required for interaction with CAV3. /evidence=ECO:0000269|PubMed:10988290	819..895		74/75 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	823..895		70/71 (99%)
		Required for binding DMD and UTRN	880..895		14/14 (100%)
		PPXY motif	889..892		2/2 (100%)
Dag1	NP_446149.1	Dystroglycan_repeat	60..161	CDD:206636	92/100 (92%)
		a_DG1_N2	180..302	CDD:465761	114/121 (94%)
		PRK12323	<311..>402	CDD:481241	89/90 (99%)
		Dystroglycan_repeat	496..600	CDD:206636	101/103 (98%)
		DAG1	604..893	CDD:461655	267/288 (93%)