Protein Alignment TMTC3 and CYC8

DIOPT Version :10

• Sequence 1: NP_861448.2
• Gene: TMTC3 / 160418
• HGNCID: 26899
• Length: 914
• Species: Homo sapiens
• Sequence 2: NP_009670.3
• Gene: CYC8 / 852410
• SGDID: S000000316
• Length: 966
• Species: Saccharomyces cerevisiae
• Alignment Length: 398
• Identity: 82/398 - (20%)
• Similarity: 159/398 - (39%)
• Gaps: 66/398 - (16%)

Human   406 SWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFL 470
            :|  ||:..|..:|      .|.:.....:.:.|:.|.::||...::.|...:...|:||.:.:.
Yeast    48 TW--LSIASLAETL------GDGDRAAMAYDATLQFNPSSAKALTSLAHLYRSRDMFQRAAELYE 104

Human   471 QATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLA 535
            :|..|.|:.......:|..|..|:..:.|..:|..|...:..            ||...::..:
Yeast   105 RALLVNPELSDVWATLGHCYLMLDDLQRAYNAYQQALYHLSN------------PNVPKLWHGI- 156

Human   536 NLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDR------ 594
            .::......|:.|::.:.:.:.:.|.|::|    .|:..::....|.:..:.:|||..|
Yeast   157 GILYDRYGSLDYAEEAFAKVLELDPHFEKA----NEIYFRLGIIYKHQGKWSQALECFRYILPQP 217

Human   595 ----NNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESG------EVKL 649
                ...|:|:.|..|...:.|...|.:.:...|..|..|       |.|:|:.|      .|:.
Yeast   218 PAPLQEWDIWFQLGSVLESMGEWQGAKEAYEHVLAQNQHH-------AKVLQQLGCLYGMSNVQF 275

Human   650 --RPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALF--NLAL 710
              ..:|...||..:..:|.||..:::||.:.|.......|....::|:  ..|.|:.:|  ::.:
Yeast   276 YDPQKALDYLLKSLEADPSDATTWYHLGRVHMIRTDYTAAYDAFQQAV--NRDSRNPIFWCSIGV 338

Human   711 LYSQTAKELKALPILEELLRYYPDHIK------GLILKGDILMNQKKDILGAKKCFERILEMDPS 769
            ||.|.::...||......:|..| :|.      |.:.  :...||..|.|.|   :::...:|.:
Yeast   339 LYYQISQYRDALDAYTRAIRLNP-YISEVWYDLGTLY--ETCNNQLSDALDA---YKQAARLDVN 397

Human   770 NVQGKHNL 777
            ||..:..|
Yeast   398 NVHIRERL 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMTC3	NP_861448.2	TMTC_DUF1736	258..331	CDD:462468
		TPR	439..668	CDD:440225	48/246 (20%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	446..479		9/32 (28%)
		TPR repeat	446..474	CDD:276809	7/27 (26%)
		TPR repeat	479..523	CDD:276809	6/43 (14%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	480..513		6/32 (19%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	529..562		3/32 (9%)
		TPR repeat	530..557	CDD:276809	2/26 (8%)
		TPR repeat	562..592	CDD:276809	6/29 (21%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	563..596		7/42 (17%)
		LapB	566..802	CDD:442196	52/238 (22%)
		TPR repeat	597..625	CDD:276809	6/27 (22%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	668..701		6/32 (19%)
		TPR repeat	668..696	CDD:276809	6/27 (22%)
		TPR repeat	701..731	CDD:276809	7/31 (23%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	702..735		9/34 (26%)
		TPR repeat	736..765	CDD:276809	7/34 (21%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	737..770		7/38 (18%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	771..804		2/7 (29%)
		TPR repeat	771..799	CDD:276809	2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	847..891
CYC8	NP_009670.3	LapB	46..326	CDD:442196	61/311 (20%)
		TPR repeat	46..74	CDD:276809	6/33 (18%)
		TPR repeat	80..108	CDD:276809	7/27 (26%)
		TPR repeat	113..143	CDD:276809	6/29 (21%)
		TPR repeat	150..178	CDD:276809	2/28 (7%)
		TPR repeat	184..211	CDD:276809	6/30 (20%)
		TPR repeat	223..253	CDD:276809	7/29 (24%)
		TPR	251..>414	CDD:440225	40/170 (24%)
		TPR repeat	258..290	CDD:276809	8/31 (26%)
		TPR repeat	296..324	CDD:276809	6/29 (21%)
		TPR repeat	329..359	CDD:276809	6/29 (21%)
		TPR repeat	364..393	CDD:276809	6/33 (18%)
		MSCRAMM_ClfA	695..>910	CDD:468110