Protein Alignment TMTC3 and Spag1

DIOPT Version :10

• Sequence 1: NP_861448.2
• Gene: TMTC3 / 160418
• HGNCID: 26899
• Length: 914
• Species: Homo sapiens
• Sequence 2: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Alignment Length: 279
• Identity: 57/279 - (20%)
• Similarity: 88/279 - (31%)
• Gaps: 114/279 - (40%)

Human   100 ALPGHT----GTYILQTLNRQFQTEVGYGHMQVYEILAPPTVMANDTA------------LVERR 148
            :|.|.|    ||.::..:..::...:    |..:.::..|.|  :||.            |||..
  Fly   138 SLGGGTGSGMGTLLISKIREEYPDRI----MNTFSVVPSPKV--SDTVVEPYNATLSIHQLVENT 196

Human   149 D----------------TLRLVCSSPSPAEVRWF-----------------FNGDALPVAVRL-- 178
            |                ||:|  |||:..::...                 .|.|...:||.:
  Fly   197 DDTFCIDNEALYDICFRTLKL--SSPTYGDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMVP 259

Human   179 ---------GMSPDGRMLTRHGVRREEAGAYQCEVWNPVSVSRSEPLNLTVYFGPERVAILQDS- 233
                     |.:|    ||..|.::..|                    |||   ||....:.|:
  Fly   260 FPRLHFFMPGFAP----LTAKGSQQYRA--------------------LTV---PELTQQMFDAK 297

Human   234 TTRTGCTIKVDFNMSLTLWCVARSCPEPEYVWAFNGK-ALKN-GQDHLNISSMTAAHEGTYTCIA 296
            ...|.|    |......|.|.|          .|.|. ::|. .|..|||.|..:::...:  |.
  Fly   298 NMMTAC----DPRHGRYLTCAA----------IFRGSMSMKEVDQQMLNIQSKYSSYFVEW--IP 346

Human   297 KNSKTLLSGSASVVVKLSA 315
            .|.|..:...|...:|:||
  Fly   347 NNVKVAVCDIAPRGLKMSA 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMTC3	NP_861448.2	TMTC_DUF1736	258..331	CDD:462468	15/60 (25%)
		TPR	439..668	CDD:440225
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	446..479
		TPR repeat	446..474	CDD:276809
		TPR repeat	479..523	CDD:276809
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	480..513
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	529..562
		TPR repeat	530..557	CDD:276809
		TPR repeat	562..592	CDD:276809
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	563..596
		LapB	566..802	CDD:442196
		TPR repeat	597..625	CDD:276809
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	668..701
		TPR repeat	668..696	CDD:276809
		TPR repeat	701..731	CDD:276809
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	702..735
		TPR repeat	736..765	CDD:276809
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	737..770
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	771..804
		TPR repeat	771..799	CDD:276809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	847..891
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	37/180 (21%)
		TPR repeat	229..257	CDD:276809	4/27 (15%)
		TPR repeat	262..293	CDD:276809	11/57 (19%)
		TPR repeat	298..326	CDD:276809	9/41 (22%)