DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TMTC3 and Tmtc4

DIOPT Version :10

Sequence 1:NP_861448.2 Gene:TMTC3 / 160418 HGNCID:26899 Length:914 Species:Homo sapiens
Sequence 2:NP_650451.1 Gene:Tmtc4 / 41867 FlyBaseID:FBgn0038324 Length:705 Species:Drosophila melanogaster


Alignment Length:826 Identity:233/826 - (28%)
Similarity:367/826 - (44%) Gaps:201/826 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    11 LIVGVVTACYWNSLFCG------FVFDDVSAILDNKDLHPSTPLK--TLFQNDFWGTPMSEERSH 67
            ::|.:...||.    ||      |||||..||:.|:|:: |.|..  .:|.:||||..:....||
  Fly    18 ILVLICLLCYG----CGGLSGAKFVFDDTVAIVKNRDVN-SLPTNWTAIFTHDFWGASLLSSDSH 77

Human    68 KSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCK-LFLDNKS----SVIASLLF 127
            ||:||||.|.|...|.|..|.......||::.|.|.:::..::.: |::...|    :::::.||
  Fly    78 KSFRPLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAALF 142

Human   128 AVHPIHTEAVTGVVGRAELLSSIFFLAAFL---SYTRSKGPDNSIIWTPIALTVFLVAVATLCKE 189
            |.||||||||:||||||||:..:..|...|   :.|...||...      .|.:.|.||..|.||
  Fly   143 AAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRLGPQTG------GLIMLLTAVGMLFKE 201

Human   190 QGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRV 254
            ..:|:...|.:.:.| ..||          ..||.|..  :|:|:|.:..:..:..||.|:..|:
  Fly   202 SAVTIPMSCVLLDYF-QNGY----------YHLRFKDQ--WSLLRTRISYLFYLLGTLGLLTARL 253

Human   255 QVIQSQLPVFTRFDNPAAVSP-TPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDI 318
            .....:.|.|...|||.|.:. ..||.|:..|||.:|.||:|.|..||.||.:|.:.|:.::.|:
  Fly   254 WWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDL 318

Human   319 RNLATFTFFCFLGMLGVFSI---------RYSGDSSKTVLMALCLMALPFIPASNLFFPVGFVVA 374
            |         ..|::|.:||         |..|     :::||.||.:||:|||.:.. ||||:|
  Fly   319 R---------LQGVIGFYSIVLVALMNFRRLPG-----MMLALGLMIVPFLPASGIIC-VGFVIA 368

Human   375 ERVLYVPSMGFCILVAHG---WQKISTKSVFKKLSW-----ICLSMVILTHSLKTFHRNWDWESE 431
            ||.|||||:|||:|..:|   |...||::.    .|     |.|.::.....::|..|..||.:|
  Fly   369 ERTLYVPSIGFCLLSIYGFLYWYDSSTENT----HWRTALRILLMLLFSVMMVRTRQRATDWLNE 429

Human   432 YTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496
            ..||.|||:|..:|||:                                  |.|:.|...::...
  Fly   430 EQLFKSALQVCPDNAKV----------------------------------HYNIARLATDMGNN 460

Human   497 KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPD 561
            .:|.:.|..|..|.              ||:.:..:||.||.| ...:|..|::..|.|:...|.
  Fly   461 TKAFQHYHRAIELY--------------PNYESALMNLGNLYR-EHGQLSTAEEYIRLALQAYPA 510

Human   562 FKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALEL 626
            |..|:::.|.:.....|..||..:|.|||:...|.|..:||:..:::|.|...|||.::..|:.|
  Fly   511 FPAAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVAL 575

Human   627 NPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWM 691
            ||:                    :|:|...:|:.:                      ||:.    
  Fly   576 NPR--------------------QPKAWANILTML----------------------DNKG---- 594

Human   692 KKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGA 756
                 ||.|                    ||.|..:.|::.|:.:..|.::.::| .:.|....|
  Fly   595 -----LQDD--------------------ALRISNQALQHLPNDVSILFIRANVL-GKLKHYTEA 633

Human   757 KKCFERILEMDPSNVQGKHNLCVVYF---EEKDLLKAERCLLETLA 799
            :..::|::|::|.|.....||.|:|.   :.::.::|.|..:...|
  Fly   634 EAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIEAYRTAISISA 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TMTC3NP_861448.2 TMTC_DUF1736 258..331 CDD:462468 25/73 (34%)
TPR 439..668 CDD:440225 50/228 (22%)
TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 446..479 2/32 (6%)
TPR repeat 446..474 CDD:276809 2/27 (7%)
TPR repeat 479..523 CDD:276809 7/43 (16%)
TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 480..513 7/32 (22%)
TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 529..562 10/32 (31%)
TPR repeat 530..557 CDD:276809 9/26 (35%)
TPR repeat 562..592 CDD:276809 10/29 (34%)
TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 563..596 9/32 (28%)
LapB 566..802 CDD:442196 49/237 (21%)
TPR repeat 597..625 CDD:276809 9/27 (33%)
TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 668..701 4/32 (13%)
TPR repeat 668..696 CDD:276809 2/27 (7%)
TPR repeat 701..731 CDD:276809 4/29 (14%)
TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 702..735 5/32 (16%)
TPR repeat 736..765 CDD:276809 5/28 (18%)
TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 737..770 7/32 (22%)
TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 771..804 7/32 (22%)
TPR repeat 771..799 CDD:276809 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..891
Tmtc4NP_650451.1 TMTC_DUF1736 258..331 CDD:462468 29/81 (36%)
LapB 431..675 CDD:442196 78/364 (21%)
TPR repeat 444..472 CDD:276809 8/61 (13%)
TPR repeat 480..506 CDD:276809 9/26 (35%)
TPR repeat 511..541 CDD:276809 10/29 (34%)
TPR repeat 546..574 CDD:276809 9/27 (33%)
TPR repeat 580..608 CDD:276809 11/78 (14%)
TPR repeat 614..642 CDD:276809 5/28 (18%)
TPR repeat 647..677 CDD:276809 7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.