Protein Alignment TMTC3 and Tmtc3

DIOPT Version :10

• Sequence 1: NP_861448.2
• Gene: TMTC3 / 160418
• HGNCID: 26899
• Length: 914
• Species: Homo sapiens
• Sequence 2: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Alignment Length: 884
• Identity: 457/884 - (51%)
• Similarity: 585/884 - (66%)
• Gaps: 68/884 - (7%)

Human     5 NLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKS 69
            ||.|...|......||:||..||.||||:|||.|||||.|.|||..:|.||||||||.:|:||||
  Fly    33 NLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKS 97

Human    70 YRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFL-------------DNKSSV 121
            ||||||||||.||||..|:|..|||:|::.|..|.:::.:||:|.|             .:.|||
  Fly    98 YRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSV 162

Human   122 --------IASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPD---NSIIWTPIA 175
                    :|||||||||:||||||||||||||||||.||||||||.:|.|..   ....|
  Fly   163 SQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNW---- 223

Human   176 LTVF-----LVAVATLCKEQGITVVGICCVYEVFIAQ--------GYTL-----------PLLCT 216
            ||:|     .:..:.||||||||:.|||.|||:|:..        .:.|           |.|..
  Fly   224 LTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLAN 288

Human   217 TAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTPTRQL 281
            .:| ..|...|..:..|..||.:      ||.|:|.||.|:.||||:||||||||:.:.||.|||
  Fly   289 PSG-IRRWSSSTLWKRLSFLVGI------TLTLLVGRVYVMGSQLPIFTRFDNPASAADTPERQL 346

Human   282 TFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFTFFCFLG-MLGVFSIRYSGDSS 345
            |:.||:.:|.||||.||.|||||||||:||::...|.||:.|...|..|| |:.......:...|
  Fly   347 TYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALS 411

Human   346 KTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFKKLSW--- 407
            :|::|.|..|.|||:||||||||||||||||:||:||||:|:|||:|::::..:.   .|||
  Fly   412 RTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRG---SLSWQRF 473

Human   408 --ICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFL 470
              ..|::::|||:|||..||.||.:||:||||.:.||:.||||:||||||||||..||.||.||.
  Fly   474 SQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQ 538

Human   471 QATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLA 535
            ||..:|.||||||:|||||:.||.|..|||::|:.||:|.||..||..|.||||||||||:||||
  Fly   539 QAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLA 603

Human   536 NLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLW 600
            |||..|::||||||.|||||||||.|:.||||:||::|:|:|:..:|:|.|.:||..|..|||::
  Fly   604 NLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIY 668

Human   601 YNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEP 665
            |||.:|.:|..:..:|...||:|:||.|:|:.||.||||::||.|..:.|..:|.||...:..:.
  Fly   669 YNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDD 733

Human   666 LDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLR 730
            .:...||||||||||:...:|||.:.|:||.|:|||||||||||||.:.|.:.|.|:|.|.:|:|
  Fly   734 QNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIR 798

Human   731 YYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLL 795
            ::|.|:|||||.|||.:|..||:..|:||:..||..||.|.||.||||||:.|.|.|.||..||.
  Fly   799 HHPSHVKGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQ 863

Human   796 ETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKIS 834
            ....|||.|:||.|||.||..::...:.:....|..|::
  Fly   864 YAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPERKLA 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMTC3	NP_861448.2	TMTC_DUF1736	258..331	CDD:462468	43/72 (60%)
		TPR	439..668	CDD:440225	129/228 (57%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	446..479		22/32 (69%)
		TPR repeat	446..474	CDD:276809	21/27 (78%)
		TPR repeat	479..523	CDD:276809	26/43 (60%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	480..513		20/32 (63%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	529..562		25/32 (78%)
		TPR repeat	530..557	CDD:276809	20/26 (77%)
		TPR repeat	562..592	CDD:276809	14/29 (48%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	563..596		15/32 (47%)
		LapB	566..802	CDD:442196	116/235 (49%)
		TPR repeat	597..625	CDD:276809	11/27 (41%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	668..701		18/32 (56%)
		TPR repeat	668..696	CDD:276809	15/27 (56%)
		TPR repeat	701..731	CDD:276809	17/29 (59%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	702..735		18/32 (56%)
		TPR repeat	736..765	CDD:276809	15/28 (54%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	737..770		18/32 (56%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	771..804		18/32 (56%)
		TPR repeat	771..799	CDD:276809	15/27 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	847..891
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468	43/72 (60%)
		TPR	507..762	CDD:440225	143/254 (56%)
		TPR repeat	514..542	CDD:276809	21/27 (78%)
		TPR repeat	547..591	CDD:276809	26/43 (60%)
		TPR repeat	598..625	CDD:276809	20/26 (77%)
		TPR repeat	630..660	CDD:276809	14/29 (48%)
		LapB	634..896	CDD:442196	126/261 (48%)
		TPR repeat	665..693	CDD:276809	11/27 (41%)
		TPR repeat	737..764	CDD:276809	15/26 (58%)
		TPR repeat	803..834	CDD:276809	17/30 (57%)
		TPR repeat	839..867	CDD:276809	15/27 (56%)