DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TMTC3 and BBS4

DIOPT Version :9

Sequence 1:NP_861448.2 Gene:TMTC3 / 160418 HGNCID:26899 Length:914 Species:Homo sapiens
Sequence 2:NP_610636.1 Gene:BBS4 / 36167 FlyBaseID:FBgn0033578 Length:486 Species:Drosophila melanogaster


Alignment Length:471 Identity:99/471 - (21%)
Similarity:185/471 - (39%) Gaps:70/471 - (14%)


- Green bases have known domain annotations that are detailed below.


Human   425 NWDW-------ESEYT----LFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPD 478
            |.||       ..|:|    |....|..:.|...|:...|.....|.|...||::..::..:.|.
  Fly    35 NIDWLLHIYFTRREFTRCRRLIERELNRHLNPEYLYFVQGLIDREEGNHIEALRHLQKSAELNPR 99

Human   479 DIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANES 543
            :|..:..:|||...:.|..:|...:..|:.             |.:.....:|..|..|:....:
  Fly   100 NIETYKEIGRTLYIMGRFSQALGVFREAEQ-------------RSSRQDHEIYHYLGELLYRAAT 151

Human   544 RLEEADQLYRQAISMRPDFK---------QAYISRGELLLKMNKPLKAKEAYLKALELDRNNADL 599
            ...:.|...:|....|..|:         ::|:...||..|..:..||.|.....|.|...|:::
  Fly   152 TQSQKDVASQQQDEARTYFELAVQSGRKLESYVRLAELYRKDKQYQKAIEILENCLHLTPENSEV 216

Human   600 WYNLAIVHIELKEPNEALKNFNRALEL-------NPKHKLALFNSAIVMQESGEVKLRPEARKRL 657
            ...::::::::   ||..|..:|..|:       :||..||.   ..::|...::   ..|..:.
  Fly   217 LIEISVLYLKI---NETQKAHDRLAEVVSIERKCSPKGLLAF---GAILQSRNDI---DGALSKY 272

Human   658 LSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKAL 722
            ....|.||..|..:.|:|:.....:|...|...::|::.|.....:||:||:|:|..:.:...|.
  Fly   273 SQIANAEPEIAELWNNIGLCFFKKQKFIVAISSLRKSVWLSPLNYNALYNLSLIYIASEQYASAF 337

Human   723 PILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNV-QGKHNLCVVYFEEKD 786
            ..|...:....|:.:..:|.| :.:.:..|:..|....||...|..... .|::.|.|:.|    
  Fly   338 HTLAAAINLRKDNAECYMLLG-LCLRKLDDMENAFVALERASSMATGQQGAGRNPLVVLNF---- 397

Human   787 LLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIEPIFPTSKISSV-----EGKKIPTESV 846
               |..| .||..||...|...|.::..:|.:..:.:   .|..:|:.|:     :|..|..:|.
  Fly   398 ---ALFC-YETGRLALSTEQYNRFMSQAQDLLLPTEY---KFQATKLKSLLRISNQGNGILLDSA 455

Human   847 ---KEIRGESRQTQIV 859
               :...|.:|.|:::
  Fly   456 DMGESDLGHNRATELL 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TMTC3NP_861448.2 DUF1736 259..331 CDD:312047
TPR 1 412..445 7/30 (23%)
TPR_11 <435..802 CDD:330823 80/383 (21%)
TPR 2 446..479 7/32 (22%)
TPR repeat 446..474 CDD:276809 6/27 (22%)
TPR repeat 479..523 CDD:276809 7/43 (16%)
TPR 3 481..513 6/31 (19%)
TPR 4 528..562 6/33 (18%)
TPR repeat 530..557 CDD:276809 5/26 (19%)
TPR repeat 562..592 CDD:276809 9/38 (24%)
TPR 5 563..596 9/41 (22%)
TPR repeat 597..625 CDD:276809 4/27 (15%)
TPR 7 668..701 7/32 (22%)
TPR repeat 668..696 CDD:276809 6/27 (22%)
TPR repeat 701..731 CDD:276809 8/29 (28%)
TPR 8 703..735 8/31 (26%)
TPR 9 736..770 7/33 (21%)
TPR repeat 736..765 CDD:276809 6/28 (21%)
TPR repeat 771..799 CDD:276809 8/28 (29%)
TPR 10 772..804 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..891 3/13 (23%)
BBS4NP_610636.1 TPR_12 63..127 CDD:290160 14/63 (22%)
TPR repeat 68..95 CDD:276809 6/26 (23%)
TPR_12 97..175 CDD:290160 16/90 (18%)
TPR repeat 100..130 CDD:276809 7/42 (17%)
TPR repeat 136..175 CDD:276809 7/38 (18%)
TPR repeat 179..209 CDD:276809 8/29 (28%)
TPR_19 190..254 CDD:291240 14/66 (21%)
TPR repeat 214..242 CDD:276809 5/30 (17%)
TPR repeat 249..277 CDD:276809 6/33 (18%)
TPR_11 283..348 CDD:290150 15/64 (23%)
TPR repeat 283..311 CDD:276809 6/27 (22%)
TPR repeat 316..346 CDD:276809 8/29 (28%)
TPR repeat 351..377 CDD:276809 5/26 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.