DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TMTC3 and Utx

DIOPT Version :9

Sequence 1:	NP_861448.2	Gene:	TMTC3 / 160418	HGNCID:	26899	Length:	914	Species:	Homo sapiens
Sequence 2:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	113/560 - (20%)
Similarity:	206/560 - (36%)	Gaps:	169/560 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   431 EYTLFMSA----LKVNKNNAKLWNN------VGHALENEKNFERALKYFLQATHVQPDDIGA--- 482
            ||:..:||    |:..:||  .|.|      :|.|....:.|:.|:|.|.:..::.|:...|
  Fly   129 EYSEALSAYQKYLRFRENN--YWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEV 191

Human   483 HMNVGRTYKN--------------LNRTKEAEESYMMAKSLMPQI--IPGKKYAAR----IAPNH 527
            |:.:|...|:              |..|..:..|.:..|..:..:  :..|..||:    ...|.
  Fly   192 HLRLGLMLKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNE 256

Human   528 LNVYINL-ANLIR-----------ANESRLEEADQL--YRQAISMRPDFKQAYISRGELLLKMNK 578
            .|:.:.| |::.|           ..|.:..||:.|  .:::|...|...|:....|.....:||
  Fly   257 KNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINK 321

Human   579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQE 643
            ...|..||..::|....|||.|.::.:::.:..:|.:||:.:..|::|:..||.|..|..|:.:.
  Fly   322 VHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYES 386

Human   644 SGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNL 708
            .|::      |.....|:|                            ..|.|..|
  Fly   387 CGQL------RDAYACYLN----------------------------ATKQISFQ---------- 407

Human   709 ALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILG-AKKCFERILEMD----- 767
                                        |..:::....:..|||.:| :|...:||..::
  Fly   408 ----------------------------KSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQ 444

Human   768 ---PSNVQGKHNLCVVYFEEKDL---LKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFIE- 825
               ||....:..||.:. |..:|   |:......:|..:.|.:             ::..|.::
  Fly   445 APLPSITSKRRQLCSIE-EAWNLPISLEMNSRQQQTAQMLPRQ-------------VTKQSPVQG 495

Human   826 --PIFPTSKISSVEGKKIPTESVKEIRGESRQ--TQ---------IVKTSDNKSQSKSNKQLGKN 877
              |.:|.|::|.   ..||::.:|| .|.|:|  ||         ::..|::.:|...|.....|
  Fly   496 PPPPYPHSQLSQ---SPIPSKRIKE-DGTSQQEVTQNNSQTSAQNLINISESLNQRNFNAMPESN 556

Human   878 -GDEETPHKTTKDI-KEIEKKRVA-ALKRLEEIERILNGE 914
             ..|::...|..|| .:|.|:..: .|:||.: :.:.|.|
  Fly   557 KSSEQSVLDTFDDISNDIYKQNESIKLERLSQ-DALSNNE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMTC3	NP_861448.2	DUF1736	259..331	CDD:312047
		TPR 1	412..445		5/17 (29%)
		TPR_11	<435..802	CDD:330823	81/425 (19%)
		TPR 2	446..479		9/38 (24%)
		TPR repeat	446..474	CDD:276809	8/33 (24%)
		TPR repeat	479..523	CDD:276809	11/66 (17%)
		TPR 3	481..513		8/48 (17%)
		TPR 4	528..562		10/47 (21%)
		TPR repeat	530..557	CDD:276809	7/40 (18%)
		TPR repeat	562..592	CDD:276809	7/29 (24%)
		TPR 5	563..596		8/32 (25%)
		TPR repeat	597..625	CDD:276809	7/27 (26%)
		TPR 7	668..701		3/32 (9%)
		TPR repeat	668..696	CDD:276809	1/27 (4%)
		TPR repeat	701..731	CDD:276809	0/29 (0%)
		TPR 8	703..735		0/31 (0%)
		TPR 9	736..770		9/42 (21%)
		TPR repeat	736..765	CDD:276809	8/29 (28%)
		TPR repeat	771..799	CDD:276809	6/30 (20%)
		TPR 10	772..804		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..891		15/56 (27%)
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	9/35 (26%)
		TPR_11	156..216	CDD:290150	11/59 (19%)
		TPR repeat	186..216	CDD:276809	4/29 (14%)
		TPR repeat	228..255	CDD:276809	4/26 (15%)
		TPR_11	264..337	CDD:290150	16/72 (22%)
		TPR repeat	265..300	CDD:276809	6/34 (18%)
		TPR repeat	307..334	CDD:276809	7/26 (27%)
		TPR_11	339..402	CDD:290150	18/96 (19%)
		TPR repeat	339..369	CDD:276809	8/29 (28%)
		TPR_1	340..373	CDD:278916	8/32 (25%)
		TPR repeat	374..402	CDD:276809	8/61 (13%)
		JmjC	870..978	CDD:202224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900