DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TMTC3 and CG4341

DIOPT Version :9

Sequence 1:	NP_861448.2	Gene:	TMTC3 / 160418	HGNCID:	26899	Length:	914	Species:	Homo sapiens
Sequence 2:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster

Alignment Length:	918	Identity:	253/918 - (27%)
Similarity:	376/918 - (40%)	Gaps:	256/918 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    20 YWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLTFRLNYLL 84
            |.|:|..|||:||..|||.|.|:...||.:..|.|||||||:::..||.|:|||.||:||||||:
  Fly    46 YLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLCVLSFRLNYLI 110

Human    85 -SELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSSVIAS-LLFAVHPIHTEAVTGVVGRAELL 147
             ....|..:||:|.:.|.|.:.:.::|.:..|.:..:|:|: .|||.||||||||.||||||:|.
  Fly   111 GGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWAVLAAGALFAAHPIHTEAVAGVVGRADLA 175

Human   148 SSIFFLAAFLSYTR------SKGPDNSIIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIA 206
            :.:.:|..:|||.|      |..|..   |..:..|:.|.|...||||..||.:.:|.:::|
  Fly   176 ACVCYLLTYLSYLRHMRWRESGDPRQ---WLALGATLILAAAGLLCKETAITALLVCALFDV--- 234

Human   207 QGYTLPLLCTTAGQFLRG-KGSIPFSMLQTLVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNP 270
                           :|| .|.:.   .|.|..:.:::.:...:...|:.::......|:..|||
  Fly   235 ---------------MRGLSGQVD---KQRLRSVCIVLGALFCMAYCRLVIVPGPQTAFSSADNP 281

Human   271 AAVSPTP-TRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFTFFCFL---- 330
            .|.:|:. ||.|||.||...|..|||.|:.|..||.|..:|.:.||.|.||..:..|:..|
  Fly   282 IARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVA 346

Human   331 -----------------GMLGVF------------------------------------------ 336
                             |:...|
  Fly   347 WGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALP 411

Human   337 ----------------------------------------------SIRYSGDSSKT-------- 347
                                                          |...|..||.:
  Fly   412 CRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSS 476

Human   348 ----------------------------VLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMG 384
                                        ::|:|..:||||:|||||.|.||||||||:||:||:|
  Fly   477 SSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPSVG 541

Human   385 FCILVAHGWQKI-STKSVFKKLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKL 448
            ||:||.:|..|: |.....:.:..:..|:::...||:|..||.||..|.:|:.||:.:|.  .|.
  Fly   542 FCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAINP--PKA 604

Human   449 WNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ- 512
            ..|:|..|.::..:|.|.:...:|...:|:....|.|:|..::|......|.|.:..|....|.
  Fly   605 LGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIKFRPNL 669

Human   513 -----------IIPGKKYAA-----------------RIAPNHL--NVYINLANLIRANESRLEE 547
                       |..||:..|                 |.|.:..  :.|:.|..|. ..:.:|:.
  Fly   670 AVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALY-VEQGKLQR 733

Human   548 ADQLYRQAISMRPDFKQ----AYISRGELLLKMNKPLKAKEAYLKALELDRNN--ADLWYNLAIV 606
            |..:||:|:|..|...|    .|...|::|.::.:..:|:..:..||||..|.  |.|.|.:.:.
  Fly   734 ALAIYREALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLSYGITLA 798

Human   607 HIELKEPNEALKNFNRALELNPK-----HKLALF--------NSAIVMQESGEVKLRPE------ 652
            . .....:||...|.|||:|.|:     |..|.|        .|||..:.:.|  |.|.
  Fly   799 R-NSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAE--LAPNDYTLVV 860

Human   653 ----ARKRLLSYINEE----------PLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRS 703
                |.:.|...::.|          |.||:.:.|||.:.....:.|.|....|.|::||.....
  Fly   861 AAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPGDAI 925

Human   704 ALFNLALL 711
            .|.|||.|
  Fly   926 TLGNLAKL 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMTC3	NP_861448.2	DUF1736	259..331	CDD:312047	30/93 (32%)
		TPR 1	412..445		12/32 (38%)
		TPR_11	<435..802	CDD:330823	85/347 (24%)
		TPR 2	446..479		8/32 (25%)
		TPR repeat	446..474	CDD:276809	7/27 (26%)
		TPR repeat	479..523	CDD:276809	12/72 (17%)
		TPR 3	481..513		8/43 (19%)
		TPR 4	528..562		10/35 (29%)
		TPR repeat	530..557	CDD:276809	8/26 (31%)
		TPR repeat	562..592	CDD:276809	7/33 (21%)
		TPR 5	563..596		9/36 (25%)
		TPR repeat	597..625	CDD:276809	8/27 (30%)
		TPR 7	668..701		10/32 (31%)
		TPR repeat	668..696	CDD:276809	8/27 (30%)
		TPR repeat	701..731	CDD:276809	5/11 (45%)
		TPR 8	703..735		5/9 (56%)
		TPR 9	736..770
		TPR repeat	736..765	CDD:276809
		TPR repeat	771..799	CDD:276809
		TPR 10	772..804
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..891
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	46/122 (38%)
		DUF1736	275..343	CDD:285594	29/67 (43%)
		TPR_11	602..667	CDD:290150	15/64 (23%)
		TPR_1	602..634	CDD:278916	7/31 (23%)
		TPR repeat	602..630	CDD:276809	7/27 (26%)
		TPR repeat	635..665	CDD:276809	7/29 (24%)
		TPR_11	636..700	CDD:290150	12/63 (19%)
		TPR_1	636..668	CDD:278916	7/31 (23%)
		TPR repeat	670..694	CDD:276809	4/23 (17%)
		TPR_11	714..784	CDD:290150	19/70 (27%)
		TPR repeat	715..743	CDD:276809	8/28 (29%)
		TPR repeat	748..782	CDD:276809	7/33 (21%)
		TPR_11	755..819	CDD:290150	19/64 (30%)
		TPR repeat	787..816	CDD:276809	8/29 (28%)
		TPR_11	821..887	CDD:290150	12/67 (18%)
		TPR repeat	822..850	CDD:276809	6/27 (22%)
		TPR repeat	855..885	CDD:276809	3/29 (10%)
		TPR_11	<874..921	CDD:290150	12/46 (26%)
		TPR repeat	890..918	CDD:276809	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820