Protein Alignment TMTC3 and Tmtc3

DIOPT Version :10

• Sequence 1: NP_861448.2
• Gene: TMTC3 / 160418
• HGNCID: 26899
• Length: 914
• Species: Homo sapiens
• Sequence 2: NP_001129330.1
• Gene: Tmtc3 / 314785
• RGDID: 1306351
• Length: 920
• Species: Rattus norvegicus
• Alignment Length: 916
• Identity: 830/916 - (90%)
• Similarity: 872/916 - (95%)
• Gaps: 3/916 - (0%)

Human     1 MANINLKEITLIVGVVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEER 65
            ||:||.||:|||||||.||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     6 MADINFKEVTLIVGVVAACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEER 70

Human    66 SHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSSVIASLLFAVH 130
            |||||||||||||||||||||||||||||||.:|||||||||||||:||||.:.||||:||||||
  Rat    71 SHKSYRPLTVLTFRLNYLLSELKPMSYHLLNTVFHAVVSVIFLKVCRLFLDKRGSVIAALLFAVH 135

Human   131 PIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFLVAVATLCKEQGITVV 195
            |||||||||||||||||||:||||||||||:||||||||:||||||||.||||||||||||||||
  Rat   136 PIHTEAVTGVVGRAELLSSVFFLAAFLSYTKSKGPDNSIVWTPIALTVLLVAVATLCKEQGITVV 200

Human   196 GICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRVQVIQSQ 260
            |||||||||:||||||||||..|||||||||||||||||||:|||||||||||||||||||||||
  Rat   201 GICCVYEVFVAQGYTLPLLCAVAGQFLRGKGSIPFSMLQTLIKLIVLMFSTLLLVVIRVQVIQSQ 265

Human   261 LPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFT 325
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||:||||||.
  Rat   266 LPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESFLDVRNLATFA 330

Human   326 FFCFLGMLGVFSIRYSGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVA 390
            ||||||.||:||:||.|||||||||||.|||||||||||||||||||||||||||||||||||||
  Rat   331 FFCFLGALGIFSLRYPGDSSKTVLMALSLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVA 395

Human   391 HGWQKISTKSVFKKLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHA 455
            |||||||.|||.|||||:|||||||||:|||.|||||||||||||||||||||||||||||||||
  Rat   396 HGWQKISNKSVLKKLSWVCLSMVILTHALKTLHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHA 460

Human   456 LENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYA 520
            ||||||||:||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
  Rat   461 LENEKNFEKALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMLAKSLMPQIIPGKKYA 525

Human   521 ARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEA 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   526 ARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEA 590

Human   586 YLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLR 650
            |||||||||||||||||||||:||||||:|||||||||||||.:||||||||||:||||||||||
  Rat   591 YLKALELDRNNADLWYNLAIVYIELKEPDEALKNFNRALELNSRHKLALFNSAILMQESGEVKLR 655

Human   651 PEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQT 715
            ||||||||:||||||.||||||||||||||||||:|||.|||:|||||.||||||||||||||||
  Rat   656 PEARKRLLNYINEEPQDANGYFNLGMLAMDDKKDSEAETWMKRAIKLQPDFRSALFNLALLYSQT 720

Human   716 AKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVV 780
            ||||||||||||||||||||.|||||||||||||||||.|||||||:||||||||||||||||||
  Rat   721 AKELKALPILEELLRYYPDHTKGLILKGDILMNQKKDIAGAKKCFEKILEMDPSNVQGKHNLCVV 785

Human   781 YFEEKDLLKAERCLLETLALAPHEEYIQRHLNIVRDKISSSSFI-EPIFPTSKISSVEGK-KIPT 843
            ||||||||||||||:||||||||||||||||:||||||:||..: :|:.|..|.|..|.| ::|:
  Rat   786 YFEEKDLLKAERCLVETLALAPHEEYIQRHLSIVRDKIASSGIVDQPLSPVDKTSGTEEKDEVPS 850

Human   844 ESVKEIRGESRQTQIVKTSDNKSQSKSNKQLGKNGDEETPHKTTKDIKEIEKKRVAALKRLEEIE 908
            |.||||..|||..||:||:||: :|:||||...|.|::.||||||||||||||||||||||||||
  Rat   851 EDVKEIISESRPAQIIKTNDNR-KSQSNKQSTGNADQDAPHKTTKDIKEIEKKRVAALKRLEEIE 914

Human   909 RILNGE 914
            ||||||
  Rat   915 RILNGE 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMTC3	NP_861448.2	TMTC_DUF1736	258..331	CDD:462468	69/72 (96%)
		TPR	439..668	CDD:440225	219/228 (96%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	446..479		31/32 (97%)
		TPR repeat	446..474	CDD:276809	26/27 (96%)
		TPR repeat	479..523	CDD:276809	42/43 (98%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	480..513		31/32 (97%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	529..562		32/32 (100%)
		TPR repeat	530..557	CDD:276809	26/26 (100%)
		TPR repeat	562..592	CDD:276809	29/29 (100%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	563..596		32/32 (100%)
		LapB	566..802	CDD:442196	220/235 (94%)
		TPR repeat	597..625	CDD:276809	25/27 (93%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	668..701		28/32 (88%)
		TPR repeat	668..696	CDD:276809	24/27 (89%)
		TPR repeat	701..731	CDD:276809	29/29 (100%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	702..735		32/32 (100%)
		TPR repeat	736..765	CDD:276809	25/28 (89%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	737..770		30/32 (94%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	771..804		31/32 (97%)
		TPR repeat	771..799	CDD:276809	26/27 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	847..891		26/43 (60%)
Tmtc3	NP_001129330.1	Stt3	77..>375	CDD:440898	274/297 (92%)
		TMTC_DUF1736	263..336	CDD:462468	69/72 (96%)
		TPR	444..673	CDD:440225	219/228 (96%)
		TPR repeat	451..479	CDD:276809	26/27 (96%)
		TPR repeat	484..528	CDD:276809	42/43 (98%)
		TPR repeat	535..562	CDD:276809	26/26 (100%)
		LapB	549..804	CDD:442196	239/254 (94%)
		TPR repeat	567..597	CDD:276809	29/29 (100%)
		TPR repeat	602..630	CDD:276809	25/27 (93%)
		TPR repeat	673..701	CDD:276809	24/27 (89%)
		TPR repeat	706..736	CDD:276809	29/29 (100%)
		TPR repeat	741..770	CDD:276809	25/28 (89%)
		TPR repeat	776..799	CDD:276809	22/22 (100%)
		ParB_N_Srx	799..>841	CDD:452888	28/41 (68%)