Protein Alignment TMTC2 and Tmtc3

DIOPT Version :10

• Sequence 1: NP_689801.1
• Gene: TMTC2 / 160335
• HGNCID: 25440
• Length: 836
• Species: Homo sapiens
• Sequence 2: NP_477246.2
• Gene: Tmtc3 / 37401
• FlyBaseID: FBgn0020312
• Length: 926
• Species: Drosophila melanogaster
• Alignment Length: 915
• Identity: 279/915 - (30%)
• Similarity: 409/915 - (44%)
• Gaps: 221/915 - (24%)

Human    12 LALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLN 76
            :..|.|:......:||..||:.|:||.|.||..::|.||||||.:....||||||||..|:||.|
  Fly    45 IVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLTVLTFRFN 109

Human    77 HAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGD--------------------GYWTFMAGL 121
            :.:..|.|:.|||||:|||.:|..|:....::||..                    ....|:|.|
  Fly   110 YLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLNTCAFVASL 174

Human   122 MFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSART-WGWFLGS-GLCAGCSML 184
            :||.||:|||||.|:||||::.:|:.||.:.|.|.|.....|...|| |....|. |.|...|||
  Fly   175 LFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNWLTLFGCFGSCLLASML 239

Human   185 WKEQGVTVLAVSAVYDVFVFHRL---------------KIKQILP--------------TIYKRK 220
            .||||:|:..:..||::||.|:|               :.:|..|              |::||
  Fly   240 CKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSGIRRWSSSTLWKR- 303

Human   221 NLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLL 285
             ||..:.|:|      :||..|:|.||::.|.|:..||||:.:|: ..|.||:.||...|.||||
  Fly   304 -LSFLVGITL------TLLVGRVYVMGSQLPIFTRFDNPASAADT-PERQLTYGYLIYLNCWLLL 360

Human   286 CPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNAN 350
            ||..|..||:|..||||:...|.||:.|        ||.:..|          |..|
  Fly   361 CPSLLCCDWTMGTVPLLQGFTDSRNITT--------LLTFLAL----------GAMV-------- 399

Human   351 GHSCLSDVEYQNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYV 415
                          .|:.|.       :|....||        :::.|..:::||:||:||||.|
  Fly   400 --------------AKTCFT-------RNLALSRT--------LIMCLGWMVLPFLPASNLFFPV 435

Human   416 GFVIAERVLYIPSMGFCLLITVGARALYVKVQ---KRFLKSLIFYATATLIVFYGLKTAIRNGDW 477
            |||:|||:||:||||:|||:..|...|..:..   :||.::    |.|.|::.:.|||..||.||
  Fly   436 GFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQA----ALAILLLTHALKTHQRNLDW 496

Human   478 QNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKI------------------------------- 509
            :.|..|:.||:.||.  ||.:.|:|:.|:::.|.
  Fly   497 RTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNL 561

Human   510 ---SEAESAY--RNALY--------YRSNMA----DMLYNLGLLLQEN-SRFAEALHYYKLAIGS 556
               :|||.||  ..||:        |.:.:|    ::..||..|:.:| :|..||.|.|:.||..
  Fly   562 KRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISM 626

Human   557 RPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGH 621
            |.....||:|.|.|||...||.:|:..:.:.....:||           ....||||.::.|||.
  Fly   627 RSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNEN-----------ADIYYNLGVVFLEQGK 680

Human   622 YEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKL 686
            .::|...:.:||:..|..  .|:|.|    :.:.|.:|...|
  Fly   681 SQQAQVYFNKAIELYPEH--EQALLN----SAILLQELGGEE----------------------- 716

Human   687 LALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNA 751
                .|:....:|: |.:|.|......|.:.|...::|:...||.:..|:|..|.:.....:||.
  Fly   717 ----ARRVSRSRLY-KVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNL 776

Human   752 AHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAIL--HLNGRLQKAEANYLRALQLKPDDVI 814
            |.:|........|..:.:...|..|::...|:.||.|.  |:.. |.:||..|...|...|.:..
  Fly   777 ALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKD-LDEAEKCYRSILHYDPHNTQ 840

Human   815 TQSNL 819
            ...||
  Fly   841 GLHNL 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMTC2	NP_689801.1	ArnT	<78..>198	CDD:441412	52/141 (37%)
		TMTC_DUF1736	247..318	CDD:462468	32/70 (46%)
		TPR	488..727	CDD:440225	66/289 (23%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	493..526		14/76 (18%)
		TPR repeat	493..521	CDD:276809	12/63 (19%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	527..560		13/37 (35%)
		TPR repeat	527..555	CDD:276809	11/32 (34%)
		TPR repeat	560..590	CDD:276809	10/29 (34%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	561..594		10/32 (31%)
		TPR repeat	595..634	CDD:276809	9/38 (24%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	606..639		11/32 (34%)
		TPR repeat	642..671	CDD:276809	6/28 (21%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	643..676		6/32 (19%)
		TPR	646..>819	CDD:440225	35/174 (20%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	677..710		5/32 (16%)
		TPR repeat	679..705	CDD:276809	3/25 (12%)
		TPR repeat	710..774	CDD:276809	13/63 (21%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	711..744		8/32 (25%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	745..778		7/32 (22%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	779..812		11/34 (32%)
		TPR repeat	779..807	CDD:276809	9/29 (31%)
Tmtc3	NP_477246.2	TMTC_DUF1736	323..396	CDD:462468	35/91 (38%)
		TPR	507..762	CDD:440225	69/299 (23%)
		TPR repeat	514..542	CDD:276809	6/27 (22%)
		TPR repeat	547..591	CDD:276809	8/43 (19%)
		TPR repeat	598..625	CDD:276809	10/26 (38%)
		TPR repeat	630..660	CDD:276809	10/29 (34%)
		LapB	634..896	CDD:442196	61/258 (24%)
		TPR repeat	665..693	CDD:276809	9/27 (33%)
		TPR repeat	737..764	CDD:276809	7/26 (27%)
		TPR repeat	803..834	CDD:276809	10/31 (32%)
		TPR repeat	839..867	CDD:276809	2/7 (29%)