Protein Alignment TMTC2 and Utx

DIOPT Version :10

• Sequence 1: NP_689801.1
• Gene: TMTC2 / 160335
• HGNCID: 25440
• Length: 836
• Species: Homo sapiens
• Sequence 2: NP_609368.3
• Gene: Utx / 34377
• FlyBaseID: FBgn0260749
• Length: 1136
• Species: Drosophila melanogaster
• Alignment Length: 345
• Identity: 74/345 - (21%)
• Similarity: 131/345 - (37%)
• Gaps: 50/345 - (14%)

Human   499 LGNVLKSQSKISEAESAYRNALYYRSN----MADMLYNLGLLLQENSRFAEALHYYKLAIGSRPT 559
            ||::.....:.|||.|||:..|.:|.|    ....:|.:|:...:...|..|:..::..:...|.
  Fly   120 LGHLHLLLGEYSEALSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPN 184

Human   560 LASA---YLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGH 621
            ...|   :|..|::|.:.|....|    ||..::.   |...:....|.....:.:..||..|..
  Fly   185 FTCANEVHLRLGLMLKHCGEFHIA----LKHLQLA---LLYTYPSTFSELQVKFQIAHLYEVQNK 242

Human   622 YEEALSVYKEAI-QKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGK 685
            ::.|...|:..: :|.........:|..:|..|          | .:|.|..|.:
  Fly   243 HKAAKDGYEFLLNEKNISLELKADVYRQLGWMY----------H-CVECLGEKKE---------- 286

Human   686 LLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFN 750
                  |::.|.....|:||.||..|......|:......::.:|....:.:.|......|...:
  Fly   287 ------REANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCS 345

Human   751 AAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVIT 815
            ...:.:|.:....|.:.|..|.:|..::.||..|||.:....|:|:.|.|.||.|.:
  Fly   346 IGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATK-------- 402

Human   816 QSNLRKLWNIMEKQGLKTSK 835
            |.:.:|...|.:||.::..|
  Fly   403 QISFQKSSLIRKKQAIRMKK 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMTC2	NP_689801.1	ArnT	<78..>198	CDD:441412
		TMTC_DUF1736	247..318	CDD:462468
		TPR	488..727	CDD:440225	48/235 (20%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	493..526		11/30 (37%)
		TPR repeat	493..521	CDD:276809	8/21 (38%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	527..560		5/32 (16%)
		TPR repeat	527..555	CDD:276809	4/27 (15%)
		TPR repeat	560..590	CDD:276809	8/32 (25%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	561..594		8/35 (23%)
		TPR repeat	595..634	CDD:276809	7/39 (18%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	606..639		6/33 (18%)
		TPR repeat	642..671	CDD:276809	5/28 (18%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	643..676		7/32 (22%)
		TPR	646..>819	CDD:440225	37/172 (22%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	677..710		7/32 (22%)
		TPR repeat	679..705	CDD:276809	3/25 (12%)
		TPR repeat	710..774	CDD:276809	9/63 (14%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	711..744		4/32 (13%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	745..778		6/32 (19%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	779..812		12/32 (38%)
		TPR repeat	779..807	CDD:276809	12/27 (44%)
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	4/33 (12%)
		LapB	171..444	CDD:442196	60/294 (20%)
		TPR repeat	186..216	CDD:276809	8/36 (22%)
		TPR repeat	228..255	CDD:276809	5/26 (19%)
		TPR repeat	265..300	CDD:276809	10/61 (16%)
		TPR repeat	307..334	CDD:276809	2/26 (8%)
		TPR repeat	339..369	CDD:276809	5/29 (17%)
		TPR repeat	374..402	CDD:276809	12/27 (44%)
		JmjC	870..978	CDD:396791