Protein Alignment TMTC2 and Tmtc2

DIOPT Version :10

• Sequence 1: NP_689801.1
• Gene: TMTC2 / 160335
• HGNCID: 25440
• Length: 836
• Species: Homo sapiens
• Sequence 2: NP_608558.1
• Gene: Tmtc2 / 33276
• FlyBaseID: FBgn0028481
• Length: 938
• Species: Drosophila melanogaster
• Alignment Length: 921
• Identity: 340/921 - (36%)
• Similarity: 482/921 - (52%)
• Gaps: 126/921 - (13%)

Human     5 LVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLC 69
            |...:|...||||||.|.|.|||.|||..|.|:...|||...|.||||||.||.||||.|:||||
  Fly    36 LFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLC 100

Human    70 TLSFRLNHAI-GGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAV 133
            .||||||:.| ||..||.:||||.|||...|.|....::.||...:....||.:||:||||||||
  Fly   101 VLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWAVLAAGALFAAHPIHTEAV 165

Human   134 AGIVGRADVGASLFFLLSLLCYIKHCSTR-GYSARTWGWFLGSGL-CAGCSMLWKEQGVTVLAVS 196
            ||:|||||:.|.:.:||:.|.|::|...| ....|.| ..||:.| .|...:|.||..:|.|.|.
  Fly   166 AGVVGRADLAACVCYLLTYLSYLRHMRWRESGDPRQW-LALGATLILAAAGLLCKETAITALLVC 229

Human   197 AVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAA 261
            |::||       ::.:...:.|::..|:.:.:..|.    .:...||..:.....:||::|||.|
  Fly   230 ALFDV-------MRGLSGQVDKQRLRSVCIVLGALF----CMAYCRLVIVPGPQTAFSSADNPIA 283

Human   262 DSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLL----- 321
            .:.|..||.|||.|||..||.|||.|:.|||||.|||:|.:.::.|.||..:..||:.|:
  Fly   284 RTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAWG 348

Human   322 ----LL----------------------------------------------AYYGLKSPSVD-R 335
                ||                                              ||:..:..::. |
  Fly   349 SCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPCR 413

Human   336 ECNGKTVTNGKQNANGH------------------------------SC-----LSDVEYQNSET 365
            :||       ..|::|:                              ||     .|.....:|.:
  Fly   414 DCN-------NNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSS 471

Human   366 KSSFASKVENGIK---NDVSQRTQLPSTEN--IVVLSLSLLIIPFVPATNLFFYVGFVIAERVLY 425
            .||.:|.:..|.:   .|.:.....|:..:  ::::|||.|.:||:||:||.||||||:|||:||
  Fly   472 SSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLY 536

Human   426 IPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKV 490
            :||:|||||:..|...|....|:  .::::..:.:.|:....|:|..||.||::||.||||.|.:
  Fly   537 LPSVGFCLLVGYGVSKLMSCNQR--TRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAI 599

Human   491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIG 555
            ||.||.||||:||.||.:..||:...:.|:.:|.||||:.:|||:|.|....:..|:..::.||.
  Fly   600 NPPKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIK 664

Human   556 SRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQG 620
            .||.||.||||.||..:..|:.::|.......|.:....::|..||..:.:|....||.||.|||
  Fly   665 FRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQG 729

Human   621 HYEEALSVYKEAIQKMPRQFAPQS---LYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLT 682
            ..:.||::|:||:..:|.  .||.   ||..:|:...||.:..|||..:..:|..:.:.:.|||:
  Fly   730 KLQRALAIYREALSSLPG--LPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLS 792

Human   683 YGKLLAL-TGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFD 746
            ||..||. :.|.||||..|.:|::|.|.:.:.|.||.:||..::|..|:|...::||||...::.
  Fly   793 YGITLARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAELAPNDYT 857

Human   747 VVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPD 811
            :|..||..:|.......||.:|..|..|||....|..||||||||.||...|.|:|..||:|:|.
  Fly   858 LVVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPG 922

Human   812 DVITQSNLRKL 822
            |.||..||.||
  Fly   923 DAITLGNLAKL 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMTC2	NP_689801.1	ArnT	<78..>198	CDD:441412	54/122 (44%)
		TMTC_DUF1736	247..318	CDD:462468	34/70 (49%)
		TPR	488..727	CDD:440225	91/242 (38%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	493..526		14/32 (44%)
		TPR repeat	493..521	CDD:276809	13/27 (48%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	527..560		12/32 (38%)
		TPR repeat	527..555	CDD:276809	9/27 (33%)
		TPR repeat	560..590	CDD:276809	11/29 (38%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	561..594		10/32 (31%)
		TPR repeat	595..634	CDD:276809	16/38 (42%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	606..639		14/32 (44%)
		TPR repeat	642..671	CDD:276809	10/31 (32%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	643..676		10/35 (29%)
		TPR	646..>819	CDD:440225	68/173 (39%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	677..710		16/33 (48%)
		TPR repeat	679..705	CDD:276809	14/26 (54%)
		TPR repeat	710..774	CDD:276809	20/63 (32%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	711..744		12/32 (38%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	745..778		11/32 (34%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	779..812		18/32 (56%)
		TPR repeat	779..807	CDD:276809	15/27 (56%)
Tmtc2	NP_608558.1	TMTC_DUF1736	270..343	CDD:462468	35/72 (49%)
		TPR	597..852	CDD:440225	97/256 (38%)
		TPR repeat	602..630	CDD:276809	13/27 (48%)
		TPR repeat	635..665	CDD:276809	11/29 (38%)
		TPR repeat	670..694	CDD:276809	9/23 (39%)
		TPR repeat	715..743	CDD:276809	13/27 (48%)
		TPR repeat	748..782	CDD:276809	11/33 (33%)
		TPR	780..>933	CDD:440225	63/152 (41%)
		TPR repeat	787..816	CDD:276809	14/28 (50%)
		TPR repeat	822..850	CDD:276809	9/27 (33%)
		TPR repeat	855..885	CDD:276809	8/29 (28%)
		TPR repeat	890..918	CDD:276809	15/27 (56%)