Protein Alignment DAB2 and Dab

DIOPT Version :10

• Sequence 1: NP_001334.2
• Gene: DAB2 / 1601
• HGNCID: 2662
• Length: 770
• Species: Homo sapiens
• Sequence 2: NP_001163455.2
• Gene: Dab / 39866
• FlyBaseID: FBgn0000414
• Length: 2360
• Species: Drosophila melanogaster
• Alignment Length: 819
• Identity: 218/819 - (26%)
• Similarity: 345/819 - (42%)
• Gaps: 207/819 - (25%)

Human    42 RFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIID 106
            ||.||||::|||||||.:|.:||||:|.|:::..||   .|.|:.|:|||||.:::::.|:::.|
  Fly    43 RFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLK---MAIRAAGEHKQRITIHVTIDGLRLRD 104

Human   107 EKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGG-EGQHQFFAIKTGQQAEPLVVDLKDLFQVIY 170
            ||||...:.|||:||||||:|:||:|||||:.|. :..|:||.|||.:.|..:|:.::|||||::
  Fly   105 EKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDSGHRFFGIKTDKAASQVVLAMRDLFQVVF 169

Human   171 NVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKS------GVDQMDL-FGDMSTPPDLN-- 226
            .:||||.|..:.:...|::.:.|..|..|    :.|||      |:...|| .|.:|:...|.
  Fly   170 ELKKKEIEMARQQIQGKSLHDHSSQLASL----SSLKSSGLGGMGLGHSDLASGGISSGHALTLL 230

Human   227 ----------------------SPTESKDIL------LVDLNSEIDTNQNSLRENPFLT-NGITS 262
                                  |.:.:|::.      ||||..|:.:.|..:.:...:| |..|:
  Fly   231 GSSLSTTNGTSRLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTT 295

Human   263 CS---LPRPTPQASFLPENAFSANLNFFPT-----PNPDPFRDDPFTQPDQSTP---SSFDSLKS 316
            .|   ...|:...|...::.|..:..:.|:     |.||..|:.  .:|...||   :|.|::.|
  Fly   296 SSTGGAGHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNR--HKPPNKTPDAVTSLDAMLS 358

Human   317 PDQKKENSSSSSTPLSNG--PLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQN 379
            |   ...:|||....|.|  ..:.|.|.:.|:.||                            ||
  Fly   359 P---PPGTSSSHGSASAGLQAADNDDDNWLQELDQ----------------------------QN 392

Human   380 GVSEREQ----NGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPG 440
            .|.:..:    :|.....:..|...|.    |.....:|..|.:..|.|   :|.:....||..|
  Fly   393 DVFDTSKVVSSSGLGSVLAMAPLASSE----STATPTQQLTEVAAGSGP---LADLDIGLSTALG 450

Human   441 RGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQP----------TALQPNPLDLFK---TSAP 492
            ...:|     :.:|:.|.|..  .:|.|    ||:.          ..|:..|..|.|   :.:.
  Fly   451 NEEQT-----STILSLDAFTD--LDPLG----TGRTRPYVDKKYFFQELKNPPKKLLKELSSGSQ 504

Human   493 APVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQ 557
            |.:|..:.||.:....|:      .|...:.:.:.|.. :..|.|...|...:..|:...:...|
  Fly   505 AGLGLGLSLGQLDGLFPE------DSTTISTTTTTATN-ITAGNPQQNSANTLTSTASTAASLGQ 562

Human   558 --------PSPFAASTPPPVPVVWGPSASVAPNA------WSTTSPLGNPFQSNIFPAPA---VS 605
                    |.|.    |.|:.:....|.|:.|:|      ...|:|          |.|.   .:
  Fly   563 LLSTVALNPDPL----PAPISIPTSISHSITPSAELKLLLGHVTNP----------PNPTGHYYT 613

Human   606 TQPPSMHSSLLVTPPQPPPRAGP---PKDISSDAFTALDPLGDKEIKDVKEMFKD---FQLRQPP 664
            |:||:::|   :..|.||  |.|   |:|  :|.|:......|.:.....::|..   |:...||
  Fly   614 TEPPTLNS---LENPHPP--ADPVLLPRD--TDPFSPTRKKSDPDPFQESDLFAKLDAFEFEAPP 671

Human   665 AVPARKGEQTSSGTLSAFASYFNS--KVGIPQENADHDDFDANQLLNKINEPP-----KPAPRQV 722
            ||||......::.|.   |:.||.  :|.:|.|         .:|  ::.:||     :|.....
  Fly   672 AVPAPSIPNLATETK---ANVFNGPLQVQLPPE---------KEL--QLQQPPSTVRNRPTASVS 722

Human   723 SLP------VTKSTDNAFENPFFKD--SFGSSQASVASS 753
            :||      |..|..|......|..  |||.|.:.:.||
  Fly   723 ALPSGGALDVISSISNKKMPHLFGQARSFGKSGSDIGSS 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAB2	NP_001334.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		PTB_Dab	35..172	CDD:269926	67/130 (52%)
		Required for localization to clathrin-coated pits. /evidence=ECO:0000250	230..447		52/240 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..482		46/221 (21%)
		DPF 1	293..295		1/1 (100%)
		DPF 2	298..300		0/1 (0%)
		Sufficient for interaction with GRB2. /evidence=ECO:0000250	604..732		37/146 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	604..629		9/27 (33%)
		Required for interaction with CSK. /evidence=ECO:0000250	619..627		3/7 (43%)
		Required for interaction with MYO6. /evidence=ECO:0000250	649..770		31/123 (25%)
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000250	663..671		6/7 (86%)
		Sufficient for interaction with SH3KBP1 SH3 domain. /evidence=ECO:0000250	709..725		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..770		6/12 (50%)
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	72/140 (51%)
		PRK12727	542..>708	CDD:237182	46/200 (23%)