DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Igfals and CG32055

DIOPT Version :9

Sequence 1:	NP_001351825.1	Gene:	Igfals / 16005	MGIID:	107973	Length:	638	Species:	Mus musculus
Sequence 2:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	140/488 - (28%)
Similarity:	212/488 - (43%)	Gaps:	67/488 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse   145 LRSLEPQALLGLQNLYHLHLERNLLRSLAAG--LFRHTPSLASLS--LGNNL-----------LG 194
            :::|:..|||.|..::...|:.  ...|..|  |.|...|...|:  :|.|.           :.
  Fly     1 MQALQVLALLLLSGVFGKDLQE--CEDLGNGSYLCREIESFEQLNRYVGKNWKSVKVVNEHTGIE 63

Mouse   195 RLEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCGLGELRELD 259
            |.|:|...|||.|..|:|..:..|.|.:...|....|.:|.|...:|..|:........|:...|
  Fly    64 RAEDGELPGLSTLLQLDLSESGGVTLGEKGLQDFKALQKLNLTHAQLDELKSEQFPNPSEMINFD 128

Mouse   260 LSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPGL 324
            :|.|.:.::...:......|.......|||..:.|.||..||.||:|||:.|....:   |....
  Fly   129 VSYNDILAITTKLMSGFGNLVYANFSENLIAVIEPNAFRHMKNLRFLDLTTNYQENI---TLGEN 190

Mouse   325 LGLHVLRLAHNAITSLRPRTFKDLHF-----LEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQ 384
            ..|..|.:::|.:     |.|:..|.     ||||.|..|.:..|....|..|..|.||.:::|.
  Fly   191 ANLRFLSISNNNL-----RDFQWCHLRVLPKLEELHLHSNWLEHLDMGIFYALPNLRVLNVSNNN 250

Mouse   385 IHEVKVGAFFGLFNVAVMNL---SGNCLRSLPEHVFQGLGRLHSLHLEHSCLGRIRLHTFAGLSG 446
            :.|:|...|.....:|.:.|   |.|.::.|.:.||..|.:|.:|:|..:.:.||....|.|||.
  Fly   251 LFEIKRTLFMAPGEIAPLELLDYSSNIVKVLDDSVFCRLKKLRTLNLWLNQINRIHPRAFLGLSS 315

Mouse   447 LRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLPRQLF--QGLGQLEYLLLSN------- 502
            |:.|.|:.|.||.:.:...|.|:.|.:|||:.|.:..|..::|  :.|.:|.||.|||
  Fly   316 LQTLHLQGNKISILPDDVFANLTALEKLDLSKNNIQKLGLRVFGERILRKLIYLDLSNNYIADLH 380

Mouse   503 -----------------NQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLRYLNLRN 550
                             |:|..|...:..||::...|.::.||||.....:..:|.||.:|.|.|
  Fly   381 PLALSSMPFIKELRLRRNRLVSLDLRMFAPLRQLQLLTINENRLEEIDGEILDTLDRLNHLELNN 445

Mouse   551 NSLQTFVPQ-------PGLERLWLDANPWDCSC 576
            |.| ||:|.       ..|..:.|:.|||.|.|
  Fly   446 NRL-TFLPDLKSSQNLLQLRNITLEGNPWQCLC 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Igfals	NP_001351825.1	LRRNT	75..113	CDD:214470
		leucine-rich repeat	92..110	CDD:275380
		PLN00113	96..>558	CDD:331614	132/461 (29%)
		leucine-rich repeat	114..134	CDD:275380
		leucine-rich repeat	135..158	CDD:275380	5/12 (42%)
		leucine-rich repeat	159..182	CDD:275380	5/24 (21%)
		leucine-rich repeat	183..206	CDD:275380	8/35 (23%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		leucine-rich repeat	255..278	CDD:275380	3/22 (14%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..396	CDD:275380	7/20 (35%)
		leucine-rich repeat	423..446	CDD:275380	8/22 (36%)
		leucine-rich repeat	447..470	CDD:275380	8/22 (36%)
		leucine-rich repeat	471..494	CDD:275380	8/24 (33%)
		leucine-rich repeat	495..516	CDD:275380	9/44 (20%)
		leucine-rich repeat	519..542	CDD:275380	6/22 (27%)
		leucine-rich repeat	543..561	CDD:275380	9/24 (38%)
		TPKR_C2	570..613	CDD:326558	5/7 (71%)
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		LRR_8	128..180	CDD:290566	17/51 (33%)
		leucine-rich repeat	128..147	CDD:275380	3/18 (17%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		leucine-rich repeat	172..192	CDD:275380	7/22 (32%)
		LRR_RI	<187..400	CDD:238064	62/217 (29%)
		LRR_8	192..251	CDD:290566	19/63 (30%)
		leucine-rich repeat	193..216	CDD:275380	6/27 (22%)
		leucine-rich repeat	217..240	CDD:275380	9/22 (41%)
		leucine-rich repeat	241..267	CDD:275380	7/25 (28%)
		leucine-rich repeat	268..291	CDD:275380	7/22 (32%)
		LRR_8	290..350	CDD:290566	22/59 (37%)
		leucine-rich repeat	292..315	CDD:275380	8/22 (36%)
		leucine-rich repeat	316..339	CDD:275380	8/22 (36%)
		LRR_8	340..400	CDD:290566	15/59 (25%)
		leucine-rich repeat	340..365	CDD:275380	8/24 (33%)
		leucine-rich repeat	366..389	CDD:275380	6/22 (27%)
		leucine-rich repeat	390..413	CDD:275380	5/22 (23%)
		LRR_8	391..448	CDD:290566	17/56 (30%)
		leucine-rich repeat	414..437	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910