DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Igfals and CG18095

DIOPT Version :9

Sequence 1:	NP_001351825.1	Gene:	Igfals / 16005	MGIID:	107973	Length:	638	Species:	Mus musculus
Sequence 2:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	139/478 - (29%)
Similarity:	198/478 - (41%)	Gaps:	87/478 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse   176 LFRHTPSLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNK 240
            |.|.|..|.||:|.|..|..:|.|.|....||..|.|..:.|..|.|....||..|..|.|:.|.
  Fly    34 LIRKTELLTSLTLSNCTLPHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNN 98

Mouse   241 LTYLQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRW 305
            |:.|:......||.|..||||.|.|..:....|...|:||:
  Fly    99 LSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQ------------------------ 139

Mouse   306 LDLSHNRVAGLLEDTFPGLLGLHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFE 370
            |||.:||::.:..|:|.||..|..|.|..|.:..:....|:.||.|..|.|.||||..:...:||
  Fly   140 LDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFE 204

Mouse   371 GLGQLEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGNCLRSLPEHVFQGLGRLHSLHLEHSCLGR 435
            ....|..|.|:.|.:..::..:..||..:..:|||.|.|:.|...||.....|..|.|.::.:.:
  Fly   205 SNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITK 269

Mouse   436 IRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLPRQLFQGLGQLEYLLL 500
            :.....:||..|.||.:..|.:..|.::||..|..||:||::.|.||.||..||....|||.::|
  Fly   270 LNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIIL 334

Mouse   501 SNNQLTMLSE-------------------------DVLGPLQRAF--WLDLSHNRLETPAEGLFS 538
            :||::..:|.                         |.|.|....|  ::|||.|||::..   .|
  Fly   335 ANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKSLN---LS 396

Mouse   539 SLGRLRYLNLRNNSLQTFVPQPGLERLWLDANPWDCSCPLKALRDFALQNPGVVPRFVQTVCEGD 603
            ||...||:||.:|:                   |.|:              .:|...||.:....
  Fly   397 SLLHFRYINLADNN-------------------WSCN--------------WLVANLVQKLPNSV 428

Mouse   604 DCQPVYTYNNITCAGPANVSGLD 626
            :....:|..|.......||.|:|
  Fly   429 NFARPWTVINNLSENTTNVEGID 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Igfals	NP_001351825.1	LRRNT	75..113	CDD:214470
		leucine-rich repeat	92..110	CDD:275380
		PLN00113	96..>558	CDD:331614	128/408 (31%)
		leucine-rich repeat	114..134	CDD:275380
		leucine-rich repeat	135..158	CDD:275380
		leucine-rich repeat	159..182	CDD:275380	3/5 (60%)
		leucine-rich repeat	183..206	CDD:275380	9/22 (41%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	2/22 (9%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..396	CDD:275380	4/20 (20%)
		leucine-rich repeat	423..446	CDD:275380	5/22 (23%)
		leucine-rich repeat	447..470	CDD:275380	8/22 (36%)
		leucine-rich repeat	471..494	CDD:275380	11/22 (50%)
		leucine-rich repeat	495..516	CDD:275380	8/45 (18%)
		leucine-rich repeat	519..542	CDD:275380	10/24 (42%)
		leucine-rich repeat	543..561	CDD:275380	5/17 (29%)
		TPKR_C2	570..613	CDD:326558	6/42 (14%)
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	9/22 (41%)
		LRR_8	64..123	CDD:290566	23/58 (40%)
		leucine-rich repeat	65..88	CDD:275380	8/22 (36%)
		leucine-rich repeat	89..112	CDD:275380	7/22 (32%)
		leucine-rich repeat	113..136	CDD:275380	8/22 (36%)
		LRR_RI	115..384	CDD:238064	84/292 (29%)
		LRR_8	135..195	CDD:290566	24/83 (29%)
		leucine-rich repeat	137..160	CDD:275380	11/46 (24%)
		leucine-rich repeat	161..184	CDD:275380	6/22 (27%)
		LRR_8	184..243	CDD:290566	19/58 (33%)
		leucine-rich repeat	185..208	CDD:275380	9/22 (41%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_8	232..289	CDD:290566	16/56 (29%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		LRR_8	280..339	CDD:290566	25/58 (43%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		leucine-rich repeat	305..328	CDD:275380	11/22 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BF9C
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4254
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.820