DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AP2A1 and AP-1gamma

DIOPT Version :9

Sequence 1:XP_011524858.1 Gene:AP2A1 / 160 HGNCID:561 Length:994 Species:Homo sapiens
Sequence 2:NP_788891.2 Gene:AP-1gamma / 31842 FlyBaseID:FBgn0030089 Length:982 Species:Drosophila melanogaster


Alignment Length:984 Identity:243/984 - (24%)
Similarity:420/984 - (42%) Gaps:208/984 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    15 FTDLSERAWDLDEVVIVEVLKTCSEGKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKL 79
            ||:..||........:.::::.....::...|...:|||.|.|||.|:.:   |...:.:.:.||
  Fly    33 FTEAVERVRMPTPTRLRDLIRQIRAARTAAEERAVVNKECAYIRSTFREE---DSVWRCRNIAKL 94

Human    80 LFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTF 144
            |:|.:||:...||.:|.:.|.:|.::|:|:||||...:|::...::..||.|.:||||.|.....
  Fly    95 LYIHMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFV 159

Human   145 MCLALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARV 209
            :.|||..:..:.|.||....|:::.|::.:.::.  :::.|.||..|:.:..|:|:.:  :....
  Fly   160 VGLALCTLGAIASPEMARDLASEVERLMKSPNTY--IRKKATLCAFRVIRRVPELMEI--FLPAT 220

Human   210 VHLLNDQHMGVVTAAVSLITCLCKKNPDDF---------KTCVSLAVSRLSRIVSSASTDLQDYT 265
            ..||::::.|::...|:|||.:|:.:.|..         :..|...|..|..::....:...|.:
  Fly   221 RSLLSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS 285

Human   266 YYFVPAPWLSVKLLRLLQC--YPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILF 328
              .|..|:|.||:||||:.  :..| ||:      |.:..:|.:.....::.|    |..|.||:
  Fly   286 --GVSDPFLQVKILRLLRILGHNDP-DAS------EAMNDILAQVATNTETSK----NVGNTILY 337

Human   329 ETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINA 393
            ||:..|:...||..|.|.|.|.||:||.:.:.|:||:||.::.....::.|  ||:.|..|::..
  Fly   338 ETVLSIMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTS--AVQRHRTTILEC 400

Human   394 LKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSW 458
            || :.|||:|:||.:|.:|:.:..|.:.:..|:|.:||.||...:.:....:.:.||:|:....|
  Fly   401 LK-DPDVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRW 464

Human   459 YVDTILNLIRIAGDYVSEEVWYRVLQIVTNRD-DVQGYAAKTVFEALQ-APACHEN--MVKVGGY 519
            ::||.|:::..||:||.::|....:|:|::.. ..|.|.....:|:|| |..|.:.  :::|..:
  Fly   465 HLDTQLSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVW 529

Human   520 ILGEFGNLI---AGDPRSSPPVQFSLL--HSKF---HLCSVATRALLLSTYIKFINLFPETKATI 576
            .:||:|:|.   |.:.....|.:..|:  :.||   ...|..::...|.:..|......:....|
  Fly   530 AIGEYGDLFMYGANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEI 594

Human   577 QGVLRA-GSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSI-LAKLKRKKGP 639
            |.::.: ||.|   :|:||||.||:        |.:........||..|:..:: ::::..:.|.
  Fly   595 QALITSFGSHL---NVDLQQRGVEF--------TQLFGHYKHLRPPLLEKMPAMQISRISSQNGE 648

Human   640 GAGSALDDGRRDPSSNDINGG-------MEPTPST------------------------------ 667
            ..|.:.||...|...|.:.||       :|...:|                              
  Fly   649 SGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGSTDLSAGGAGDLVAATD 713

Human   668 -------------------VSTPSPSADLLGLRAAPPPA----APPASAGAGNLLVDVFDGPAAQ 709
                               ||......|||.|..:.|.:    ||....|.|.::..|.|...:.
  Fly   714 LSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGDNNQSS 778

Human   710 PS-----LGPTPEEAFLSELE---------------------PPAPESPMA-------------- 734
            .:     ||......|.|.|:                     |||....:|              
  Fly   779 AANMNNMLGGLDLGGFGSGLDSSASIPTNGNDLASMLGGLGAPPAASPSLAASAPVGNLIDGHAG 843

Human   735 -LLADPAPAADPGPEDIGPPIP-----EADELLNKFV------C--------KNNGVLFENQLLQ 779
             ||||..|.|......:.|..|     :.|.||.:.|      |        .|:....:..|||
  Fly   844 SLLADLNPTAASNNVVVPPQGPRLTALDKDGLLVQLVSVRGSDCMRIYMTTTNNSDNTLDQYLLQ 908

Human   780 IGVKSEFRQNLGRMYLFYGNKTSVQFQNFSP--TVVHPGDLQTQ--LAVQTK--------RVAAQ 832
            ..|:..|                 |.|..:|  :|:.||.:.||  ..|.|.        |:...
  Fly   909 AAVQRSF-----------------QLQMLTPSGSVLPPGGVITQEMRVVATSNATLRMRLRIQYV 956

Human   833 VDGGAQVQQ 841
            :||..||:|
  Fly   957 LDGQQQVEQ 965

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP2A1XP_011524858.1 Adaptin_N 46..608 CDD:279882 168/585 (29%)
HEAT repeat 349..372 CDD:293787 10/22 (45%)
HEAT repeat 386..415 CDD:293787 12/28 (43%)
HEAT repeat 425..451 CDD:293787 7/25 (28%)
Alpha_adaptinC2 772..875 CDD:197886 21/82 (26%)
Alpha_adaptin_C 881..989 CDD:280460
AP-1gammaNP_788891.2 Adaptin_N 68..624 CDD:279882 168/589 (29%)
Alpha_adaptinC2 869..972 CDD:197886 27/114 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4354
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53727
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.