Protein Alignment AARS1 and AlaRS-m

DIOPT Version :10

• Sequence 1: NP_001596.2
• Gene: AARS1 / 16
• HGNCID: 20
• Length: 968
• Species: Homo sapiens
• Sequence 2: NP_523932.2
• Gene: AlaRS-m / 38595
• FlyBaseID: FBgn0028962
• Length: 1012
• Species: Drosophila melanogaster
• Alignment Length: 1053
• Identity: 371/1053 - (35%)
• Similarity: 530/1053 - (50%)
• Gaps: 138/1053 - (13%)

Human     1 MDSTLTASEIRQRFIDFFKRNE-HTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMA 64
            :...|||.|||:.|:|.|..|. |.:|.||..:|..|||:.|.||||||||.:||.|....|
  Fly     8 LQRVLTAREIRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTAAAPH--- 69

Human    65 KLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIP 129
              .|..|:|||:|.|||||||..||.|.||||||||||:||||||||..||.||||||...:.|.
  Fly    70 --KRVVNSQKCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSFGDYFKREACAMALELLRGPYNID 132

Human   130 IERLYVTYFGGDEAAGLEADLECKQIWQNLGLDDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDR 194
            ..|||||||.||:..|:.|||||.:||::||...::|||....|||||||.|||||||:|||.|.
  Fly   133 PGRLYVTYFAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDH 197

Human   195 ---IGG-RDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVLQNKM 255
               :|. ...|.|||....::.|:||||||||||.|||.:..||...:|||||.|||.:|||||.
  Fly   198 RPDLGSVEQRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKS 262

Human   256 SNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADG-----IDMAYRVLADHARTITVALADGGRP 315
            ||||||||.|.|:.||:......|:|..    .||     :|.:||:||||||.:|..||||..|
  Fly   263 SNYDTDLFTPIFDGIQQAAKTPVYSGSF----PDGGNAAVLDTSYRILADHARMVTACLADGMLP 323

Human   316 DNTGRGYVLRRILRRAVR-----YAHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDII 375
            |...:   |||:||:|:.     :||:||      ...||.:||::||:|:||:......|.|:|
  Fly   324 DQNQK---LRRVLRKALNISEHVFAHDKL------LTQLVPIVVETLGEAYPEMAAKQQAVIDLI 379

Human   376 -NEEEV----------QFLKTLSRGRRILD-------------RKIQSLG---DSKTIPGDTAWL 413
             :|:||          .|.:.|.....:.|             |::|...   .:.|||||..:.
  Fly   380 CHEQEVYKNLRESSSKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDFLYK 444

Human   414 LYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQG---KGAGGEDLIMLDIYAIEELRA 475
            |.||||...:....:||.:.:..|::.:..|..||:||::|   :.|||....:.....|.|.:|
  Fly   445 LTDTYGLTEESFLKLAELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQA 509

Human   476 ---RGLEVTDDSPKYNYHLD-SSGSY-------------VFENTVATVMALRREKMFVEEVSTGQ 523
               :.|..||:|.||.|..| .|.||             :.:..|:.....|.::.|.:.:|
  Fly   510 MLTKRLTPTDNSHKYTYSFDKESDSYQIPPLKTRVLGMLLNDAEVSRTQGSRIQQPFTDLIS--- 571

Human   524 ECGVVLDKTCFYAEQGGQIYDEG-YLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYG-----D 582
               :|...:.||.|.|||..|.| .||......:......|...:.....|:||..:..     .
  Fly   572 ---IVTAGSNFYYESGGQQSDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSSPTDAFQ 633

Human   583 LKVGDQVWLFIDEPRRRPIMSNHTATHILNFALRSVLGEAD-QKGSLVAPDRLRFDFTAKG-AMS 645
            |.:||:|.|.:|..:|:....:|||||:||.|:||:..:.. |..|.|:.|:.:.:....| .:.
  Fly   634 LAIGDEVELQVDAQQRQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGLLGKRIQ 698

Human   646 TQQIKKAEEIANEMIEAAKAVYTQDCPLAAAKAIQ--GLRAVFDETYPDP-VRVVSIGVPVSELL 707
            ...::..|::.|.:|.:|..|..|  .|:||:.::  .:..|..|.||:. :|:|::..|  ||
  Fly   699 KTDVQLIEDLINRVICSAAPVEVQ--LLSAAEVLEQNDITMVPGEVYPEQGLRLVNVESP--EL- 758

Human   708 DDPSGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKK 772
                    .|:|.|.|.|||..|:|....|.||..:...:......||.|..|:..|:.|..|:.
  Fly   759 --------QLSSKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLKTAALLRH 815

Human   773 CLSVMEAKVKAQTAPNKDVQREIADL-GEALATAV-IP-QWQKDELRETLKSLKKVMDDLDRASK 834
            .:.::|.:.:.....|. .:.|:..: ...|.|.: :| .::.|.|....:.||::.|......|
  Fly   816 RVDLLEKQFQTDKLTNA-TEAELQTIRHNMLHTDIKLPYAFKMDTLERITEMLKRIKDSSRTTLK 879

Human   835 --ADVQKRVLEKTKQFIDSNPNQPLVILEMESGASAK--ALNEALKLFKMHSPQTSAMLFTVDNE 895
              .||:.|.|.:.|. :|::   |.::..:.|.|..:  .|..|.||    .|....::.:|.:.
  Fly   880 EFVDVEMRTLLQEKP-LDTH---PFILHYITSSALVEEIPLQRATKL----CPDRPILVISVCDS 936

Human   896 AGKITCLCQVPQNAANRGLKASEWVQQVSGLMDG-----KGGGKDVSAQATGKNVG-----CLQE 950
            ..|..| | ||:........||.|:|..:...:|     ||..........|:.|.     .|::
  Fly   937 VVKARC-C-VPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVSNLFEEQLEQ 999

Human   951 ALQLATSFAQLRL 963
            |:..|.::|:|.|
  Fly  1000 AMSKAHAYAKLYL 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AARS1	NP_001596.2	PLN02900	6..961	CDD:215487	368/1044 (35%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:38512451	750..763		4/12 (33%)
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	368/1044 (35%)