Protein Alignment SLC5A12 and kumpel

DIOPT Version :10

• Sequence 1: NP_848593.2
• Gene: SLC5A12 / 159963
• HGNCID: 28750
• Length: 618
• Species: Homo sapiens
• Sequence 2: NP_651446.2
• Gene: kumpel / 43136
• FlyBaseID: FBgn0250757
• Length: 698
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 200/607 - (32%)
• Similarity: 330/607 - (54%)
• Gaps: 61/607 - (10%)

Human     3 VKNFAVWDYVVFAALFFISSGIGVFF---------------------AIKERKKATSREFLVGGR 46
            :::|.:.||:||.|:..:.:.||.:|                     .::||:.:.:.::|||||
  Fly    99 LQHFGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGR 163

Human    47 QMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTS-----ELFLPVFYRS 106
            ||...||.|||.|||:|.:::|||.:|:|.:|..:     |::.|.|..|     .:|||||...
  Fly   164 QMKVFPVALSLVASFVSGISLLGTSTEIYVYGTQY-----AFILVTLAISGAISWYIFLPVFCNL 223

Human   107 GITSTYEYLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTF 171
            .:||||||.:.||::.||...:.:::|..||:..:.:|.|||.||||:|..:...|..|..:|..
  Fly   224 QLTSTYEYFERRFDRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICIL 288

Human   172 YCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRH 236
            |.::||:|.|||||..|..|||...|.|:|:|:...||...||:.:....||...|...||..|.
  Fly   289 YTSVGGIKGVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARM 353

Human   237 TFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHF 301
            ..:.:.|||....|...|:||:.:||.::....|..|.||..:|:|...:::..|:.||:.::.|
  Fly   354 GVFALFVGGALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGFMFVMLMCVYIGLLAFAEF 418

Human   302 KDCDPWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVK 366
            ..|||.|:|:..|.||::|.:|::....:|||.|||||..||..||::::::|:|:.|...|||:
  Fly   419 YHCDPITTGLARAKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVE 483

Human   367 SCFPH----LSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLG 427
               |.    |:::.:.::.:|:.:.||::..:.......:|.|:|.|.::..:..||:||.||:|
  Fly   484 ---PFRKKPLTERQTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVG 545

Human   428 IVFPFVNWKGALGGLLTGITLSFWVAIGAFIYPAPASKTWPL-PLSTDQC-------IKSNVTAT 484
            ::.|||..:..|.|:....:.:.::.:.|.|.....|.|:|. |:|...|       ...|.|.|
  Fly   546 MLLPFVKTESLLTGISCASSFTAYIVVRAQIAIFTGSLTFPAKPVSIQDCDYTFDLPANWNATTT 610

Human   485 GPPVLSSRPGIADTWYSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLFCFW 549
            ..|..|:..||    :.||:|:|:|||.:|.::..::.:|..|||....:...||.||  |..||
  Fly   611 ATPTESTSHGI----HEISFLWYTAVGSVGTVLGSLLATLYFGRQDPRVVDKELISPV--LRKFW 669

Human   550 SKKYKTLCWCGVQHDSGTEQEN 571
            ..||:::         .:|::|
  Fly   670 YGKYESV---------ASEEKN 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	186/561 (33%)
kumpel	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	184/552 (33%)