DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A12 and CG5687

DIOPT Version :9

Sequence 1:	NP_848593.2	Gene:	SLC5A12 / 159963	HGNCID:	28750	Length:	618	Species:	Homo sapiens
Sequence 2:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	201/536 - (37%)
Similarity:	319/536 - (59%)	Gaps:	27/536 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     6 FAVWDYVVFAALFFISSGIGVFFAIKERKKATSREFLVGGRQMSFGPVGLSLTASFMSAVTVLGT 70
            |:.:|||:...:..||.|||:|:...::..::|.|||:|. :||..||.||||.||::|:.:||.
  Fly    96 FSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGS-EMSIFPVTLSLTTSFITAIELLGN 159

Human    71 PSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATVIYIVQT 135
            |||:|..|..|::..|..:.||.:..::|.|::::..:||.||||.:||.|.:|....|:|::|.
  Fly   160 PSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRFGKEIRILGAVLYVIQM 224

Human   136 ILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVL 200
            ..||.|.|.|||:||::.||.|...:|....:||.||.:.||:||||..|:||..|:.|..:.::
  Fly   225 CFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQAAVLAVSLVLIV 289

Human   201 IQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWTITVGGTFTWLGIYGVNQSTIQRCIS 265
            ..|..::|....|.:.:::.:||..|:.|.||..|||.|::.:||.|.|..::..||:::|:|:|
  Fly   290 GLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSVVIGGFFYWTSLFCTNQASVQKCMS 354

Human   266 CKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDPWTSGIISAPDQLMPYFVMEIFATM 330
            .|:.:.||:||.|.::||.::.:...::||::::|:.||||.|:|.|||.|||:||:|:..:..:
  Fly   355 LKSLRLAKIALGFAIIGLIVVFLLNFYTGLMVFTHYADCDPLTAGRISATDQLLPYYVINTYEHI 419

Human   331 PGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKS-----CFPHLSDKLSTWISKGLCLLFGV 390
            ..:.|:|||..|:.:|.||||::|:|:.||.||.:.:     ..|......:.|:|.|    ||:
  Fly   420 SSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKISPEKGATYAKWMSLG----FGI 480

Human   391 MCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSFWVAIG 455
            ....:......:|||:||:|:::|:.||..||||.|||.....|.|||..|.|..:.|..:|.:.
  Fly   481 ASFGLVFIVEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKGAFYGGLLSLALVIFVGVV 545

Human   456 AFIYPA--PASKTWPLPLSTDQC-IKSNVT------ATGPPVLSSRPGIADTW--YSISYLYYSA 509
            |.|...  ||     ||.|.|:| ...|:|      .|.|..:....|.. :|  :.:||::||.
  Fly   546 AQIVSVEQPA-----LPTSIDKCDCHVNMTNIIGSLLTEPLEVIEEGGFT-SWPIFRLSYMWYSM 604

Human   510 VGCLGCIVAGVIISLI 525
            :|||..:..|..||||
  Fly   605 IGCLLTVFLGWFISLI 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	201/536 (38%)
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	198/531 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.920