Protein Alignment SLC5A12 and SLC5A11

DIOPT Version :10

• Sequence 1: NP_848593.2
• Gene: SLC5A12 / 159963
• HGNCID: 28750
• Length: 618
• Species: Homo sapiens
• Sequence 2: NP_609192.1
• Gene: SLC5A11 / 34117
• FlyBaseID: FBgn0031998
• Length: 600
• Species: Drosophila melanogaster
• Alignment Length: 588
• Identity: 186/588 - (31%)
• Similarity: 308/588 - (52%)
• Gaps: 53/588 - (9%)

Human     1 MEVKNFAVWDYVVFAALFFISSGIGVFFAIKERKKA------------------------TSREF 41
            ||...|...||.||..:..:|:..|::|...::.|.                        ...|:
  Fly     9 MENYRFGSVDYAVFLGMIVLSTSTGIYFGCIKKSKVKLEEAEPTLPTTTPKRRKHDFGSEKMSEY 73

Human    42 LVGGRQMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRS 106
            |:|.|.:...||.:||.||::|.||:|||.||:|.:|..:....||.:...:..|.:::|||...
  Fly    74 LLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSAL 138

Human   107 GITSTYEYLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTF 171
            .:.|:||||::||:..||..|:.::|:..||:...:||.||:|||||:|.:|........:||.|
  Fly   139 QVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCVF 203

Human   172 YCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRH 236
            |..:||:||||.|||:|::||.:..|.|.|..:.:|.|.:.:.:.:..|.||...:.:..|..||
  Fly   204 YTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVRH 268

Human   237 TFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHF 301
            |.|::.:||...|.....|||:.:||.:|..:.|.|:.::....:|:...:....:.||::|..:
  Fly   269 TVWSVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEMY 333

Human   302 KDCDPWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVK 366
            |||||.::|:|:..|||:|.||::....:.|:.|||:|..|...||:::..:|:.:.|..||.|:
  Fly   334 KDCDPLSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIVR 398

Human   367 SCFP-HLSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVF 430
            .||. ..|::.||.:.|...::.|.:..|:......:.|::....|:..:..|...|||:||::.
  Fly   399 GCFKMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGMLV 463

Human   431 PFVNWKG-ALGGLLTGITLSFWVAIGA-FIYPAPASKTWPLPLSTDQCIKSNVTATGPPVLSSRP 493
            |:.|..| |:||:.:.: |:.|::.|. |...|....:..||:|.:.|: .|||.        |.
  Fly   464 PWANTVGTAVGGIASAL-LAGWISFGTQFTIAAGELNSQKLPVSVEGCV-GNVTL--------RE 518

Human   494 GIADTW---------YSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLF--- 546
            .|   |         |.:||.:.:.:|....||.|.::||:|.....:.:.|.||.||.:.|
  Fly   519 NI---WVDEEQVFPLYRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFLPK 580

Human   547 -CF 548
             ||
  Fly   581 ECF 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	175/559 (31%)
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	173/551 (31%)