Protein Alignment SLC5A12 and CG31668

DIOPT Version :9

• Sequence 1: NP_848593.2
• Gene: SLC5A12 / 159963
• HGNCID: 28750
• Length: 618
• Species: Homo sapiens
• Sequence 2: NP_001097055.2
• Gene: CG31668 / 33395
• FlyBaseID: FBgn0051668
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 620
• Identity: 190/620 - (30%)
• Similarity: 320/620 - (51%)
• Gaps: 78/620 - (12%)

Human     1 MEVKNFAVWDYVVFAALFFISSGIGVFFAI--KERK--KATS------------------REFLV 43
            |:...|...||.||..:..:|..||::|..  |.|.  |.|:                  .::::
  Fly     1 MDTYRFGTVDYAVFLGVTILSIAIGLYFGFIRKSRNGPKTTTPTNEAPERRHQNFGSKKMNDYMM 65

Human    44 GGRQMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGI 108
            |.|.:...|||:||.||.:|||.::|||||:|.:|..:....||.:...|..|.::||||....:
  Fly    66 GSRNLRVFPVGMSLIASCISAVAIIGTPSEIYNYGTQYCFIVIALVLQGLAVSYIYLPVFSALQV 130

Human   109 TSTYEYLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYC 173
            ||:||||::||:..:|...::|:|:..:||...:.|.||||||||:|.:::.......::|..|.
  Fly   131 TSSYEYLEMRFHSAIRSIVSIIFILDVVLYLPFLAYLPALALNQVSGMNMYLIEAFIIVICVIYT 195

Human   174 TLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTF 238
            .||||||||.||.:|:|:|....||:::..:.:.....:.||....|.||...:.:..|..|||.
  Fly   196 VLGGLKAVVHTDIWQVVIMFASVLTIVVLATCYIDDQADFLEGLVRGGRLIFSETNPSPFARHTV 260

Human   239 WTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLG--LWIILVCAVFSGLIMYSHF 301
            |::.:|.||.|..:..|:|:.:.|.:|..|.|.|:.::.|.::|  .:|.|:|  :.||:::..:
  Fly   261 WSVVIGNTFYWTSLNAVHQTVVHRYMSLPTLKMARASIAFLVVGAAFFISLLC--YLGLLIFHAY 323

Human   302 KDCDPWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVK 366
            :||||.::|:|...|||:|.||:.....:.|:||||:|..|..:||:::..:|:.:.|..:|.|:
  Fly   324 RDCDPLSAGLIMNDDQLVPLFVVNSLGHVYGMPGLFIAGIFGASLSSLSVYLNSTSLVILQDLVR 388

Human   367 SCFP-HLSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVF 430
            .||. .|.:..||.:.||..::.|::..:|......:.||:..|:|:..:......|:|::|::.
  Fly   389 GCFKMELGEWASTIVVKGSIVVLGLLAFAMVFVLEKVSGVLSISVSLAAIAASSTFGIFTVGMLV 453

Human   431 PFVNWKGALGGLLTGITLSFWVAIGA-FIYPAPASKTWPLPLSTDQCIKSNVTATGPPVLSSRPG 494
            |:.|..|...|.:..:.|:.|::.|: |...:....:..||:|.:.|:.:...|
  Fly   454 PWANTVGTAVGGIASVLLTGWISFGSQFAAASGQLGSQRLPVSVEGCLANASVA----------- 507

Human   495 IADTW---------YSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPL---LIRPVCNLF- 546
             .:.|         |.:||.:.|.:|.|..:|.|.::||:|   :..||:.|   ||.||.:.|
  Fly   508 -ENAWVAEEEVFPLYRLSYHWISPIGVLTVVVVGSLVSLVT---KPTDIKSLDSDLITPVIHRFL 568

Human   547 ---CFWSKKYKTLCWCGVQHDSGTEQENLENGSAR 578
               ||                   ||.|.|..|.:
  Fly   569 PKECF-------------------EQGNAEENSVK 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	173/558 (31%)
CG31668	NP_001097055.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	166/535 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850