Protein Alignment SLC5A12 and CG31262

DIOPT Version :10

• Sequence 1: NP_848593.2
• Gene: SLC5A12 / 159963
• HGNCID: 28750
• Length: 618
• Species: Homo sapiens
• Sequence 2: NP_732222.2
• Gene: CG31262 / 318649
• FlyBaseID: FBgn0051262
• Length: 579
• Species: Drosophila melanogaster
• Alignment Length: 586
• Identity: 187/586 - (31%)
• Similarity: 307/586 - (52%)
• Gaps: 60/586 - (10%)

Human     1 MEVKNFAVWDYVVFAALFFISSGIGVFF-AIKER---KKATSR-------------EFLVGGRQM 48
            |:...|...||:|..|:..:|:|.|::| |:|::   ||:.|.             |:|:|.|.|
  Fly     1 MDNYRFGTVDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMGSRNM 65

Human    49 SFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITSTYE 113
            ...||.::|    ....:::|||||:|.:|..:.:..:|.:...:..|.::|||:....|.|.||
  Fly    66 KVIPVSITL----YRVTSIIGTPSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSALQIGSAYE 126

Human   114 YLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFD--LWGSVFATGIVCTFYCTLG 176
            ||.||||..:|..|:.:|:...:.|...:||.|||:|:||:|.:  |.|.|..  :.|..|..:|
  Fly   127 YLGLRFNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVII--LACVTYTFMG 189

Human   177 GLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWTI 241
            ||||||.||.:|:.||.:..:.|......::.|...|.:.:..|.||.:.:.:..|..|||.|::
  Fly   190 GLKAVVHTDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTNPSPYVRHTVWSV 254

Human   242 TVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDP 306
            .:||...|..:....|..:||.:|..:.|.::.|.:...:|:.|.:....|.||:::|.:|||||
  Fly   255 LIGGFSFWTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIFIALCCFMGLLLFSKYKDCDP 319

Human   307 WTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFP- 370
            .::|:|...|||:|.||::....:.|:||||:|..|...||:::|..|.::.|..||.|:..|.
  Fly   320 RSAGMILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIVRGFFKM 384

Human   371 HLSDKLSTWISKGLCLLF-GVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVN 434
            ..|::.||.:.| .|::| |::...:......:.|::....||..:..|...|:|:||::||:.|
  Fly   385 EPSERQSTILIK-TCIIFQGILAFLIVFLLQHLRGILSVCNSISSITAGTSFGVFTLGMLFPWAN 448

Human   435 WKGALGGLLTGITLSFWVAIGAFIYPAPAS-KTWPLPLSTDQCIKSNVTATGPPVLSSRPGIADT 498
            ..|...|.|:.:.|:.|::.|:.|..|... |:..||:|..:|: .|||..           .|.
  Fly   449 TIGTAVGGLSSVLLAGWISFGSQIAAASGQLKSGMLPVSVKECV-GNVTLP-----------EDP 501

Human   499 W---------YSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPL---LIRPVCNLF----C 547
            |         |.:||.:.|.:|.:..:|.|.::||||   :..||:.|   ||.||.:.|    |
  Fly   502 WVDQDQVFPLYRLSYHWVSPIGVVTAVVVGALVSLIT---KPADIKTLHAELISPVIHRFLPREC 563

Human   548 F 548
            |
  Fly   564 F 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	175/554 (32%)
CG31262	NP_732222.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	168/531 (32%)