DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A12 and CG31262

DIOPT Version :9

Sequence 1:	NP_848593.2	Gene:	SLC5A12 / 159963	HGNCID:	28750	Length:	618	Species:	Homo sapiens
Sequence 2:	NP_001138069.2	Gene:	CG31262 / 318649	FlyBaseID:	FBgn0051262	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	187/586 - (31%)
Similarity:	307/586 - (52%)	Gaps:	60/586 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEVKNFAVWDYVVFAALFFISSGIGVFF-AIKER---KKATSR-------------EFLVGGRQM 48
            |:...|...||:|..|:..:|:|.|::| |:|::   ||:.|.             |:|:|.|.|
  Fly     1 MDNYRFGTVDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMGSRNM 65

Human    49 SFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITSTYE 113
            ...||.::|    ....:::|||||:|.:|..:.:..:|.:...:..|.::|||:....|.|.||
  Fly    66 KVIPVSITL----YRVTSIIGTPSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSALQIGSAYE 126

Human   114 YLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFD--LWGSVFATGIVCTFYCTLG 176
            ||.||||..:|..|:.:|:...:.|...:||.|||:|:||:|.:  |.|.|..  :.|..|..:|
  Fly   127 YLGLRFNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVII--LACVTYTFMG 189

Human   177 GLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWTI 241
            ||||||.||.:|:.||.:..:.|......::.|...|.:.:..|.||.:.:.:..|..|||.|::
  Fly   190 GLKAVVHTDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTNPSPYVRHTVWSV 254

Human   242 TVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDP 306
            .:||...|..:....|..:||.:|..:.|.::.|.:...:|:.|.:....|.||:::|.:|||||
  Fly   255 LIGGFSFWTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIFIALCCFMGLLLFSKYKDCDP 319

Human   307 WTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFP- 370
            .::|:|...|||:|.||::....:.|:||||:|..|...||:::|..|.::.|..||.|:..|.
  Fly   320 RSAGMILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIVRGFFKM 384

Human   371 HLSDKLSTWISKGLCLLF-GVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVN 434
            ..|::.||.:.| .|::| |::...:......:.|::....||..:..|...|:|:||::||:.|
  Fly   385 EPSERQSTILIK-TCIIFQGILAFLIVFLLQHLRGILSVCNSISSITAGTSFGVFTLGMLFPWAN 448

Human   435 WKGALGGLLTGITLSFWVAIGAFIYPAPAS-KTWPLPLSTDQCIKSNVTATGPPVLSSRPGIADT 498
            ..|...|.|:.:.|:.|::.|:.|..|... |:..||:|..:|: .|||..           .|.
  Fly   449 TIGTAVGGLSSVLLAGWISFGSQIAAASGQLKSGMLPVSVKECV-GNVTLP-----------EDP 501

Human   499 W---------YSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPL---LIRPVCNLF----C 547
            |         |.:||.:.|.:|.:..:|.|.::||||   :..||:.|   ||.||.:.|    |
  Fly   502 WVDQDQVFPLYRLSYHWVSPIGVVTAVVVGALVSLIT---KPADIKTLHAELISPVIHRFLPREC 563

Human   548 F 548
            |
  Fly   564 F 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	175/554 (32%)
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	168/531 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146469
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850