Protein Alignment SLC5A12 and CG9657

DIOPT Version :9

• Sequence 1: NP_848593.2
• Gene: SLC5A12 / 159963
• HGNCID: 28750
• Length: 618
• Species: Homo sapiens
• Sequence 2: NP_001284983.1
• Gene: CG9657 / 31674
• FlyBaseID: FBgn0029950
• Length: 601
• Species: Drosophila melanogaster
• Alignment Length: 615
• Identity: 196/615 - (31%)
• Similarity: 331/615 - (53%)
• Gaps: 75/615 - (12%)

Human     3 VKNFAVWDYVVFAALFFISSGIGVFFAIK-----ERKKATSRE--------FLVGGRQMSFGPVG 54
            :::|...||:||..:..|.:.||::|.::     .::||...|        :|||||||...|:.
  Fly    10 LQSFGWPDYLVFCLMLAICAVIGIYFCLQLRLESRKQKANGSEEAASSAASYLVGGRQMKIFPIT 74

Human    55 LSLTASFMSAVTVLGTPSEVYRFGASF--------LVFFIAYLFVILLTSELFLPVFYRSGITST 111
            :||.:||:|.:|:||||:|||.:||.:        |:.|..|.|        |||||:...:.||
  Fly    75 MSLISSFISGITLLGTPTEVYLYGAQYMYIMGSLVLMGFCMYYF--------FLPVFHELNLIST 131

Human   112 YEYLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLG 176
            |:||:.|:|:.:|...:|::||.::|:..:|:|.||:|.||.||.::........:||.||..:|
  Fly   132 YKYLEQRYNRSLRLFGSVMFIVASLLWLPIVIYVPAIAFNQATGVNIHIVTPIVCVVCIFYTCIG 196

Human   177 GLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWTI 241
            |||||||||..|.::|......|||:|:...||...|.:::...:||.:.:|..|...|:||:::
  Fly   197 GLKAVVWTDVIQTLIMFGAMALVLIKGTLDIGGPGVVWQKAQETARLEVPNFSADLSERYTFYSL 261

Human   242 TVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDP 306
            .:||...||....::|:.|||.:|..|.:.|::|::..:.|:...|:...::||::|:.:..|||
  Fly   262 VLGGVAHWLKSNAISQNMIQRYLSLPTLRDARIAIWTFIAGVLAFLMICGYTGLLIYATYSQCDP 326

Human   307 WTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFPH 371
            ..:.:....|||:|..||:...:.|||||:|||..||..||::::.:|:|:.|..|||||:....
  Fly   327 LETKLAQRNDQLLPLLVMDTLGSYPGLPGVFVAGVFSAALSSLSTGLNSLSAVVLEDFVKTFRKS 391

Human   372 -LSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNW 435
             |::..:.::.:.:.::||::..::..|...:|.|:|.::::..:..||:||:|:.|::.|:||.
  Fly   392 PLTEGQTAFVMRSVVVVFGIIFVALVFAVEKLGAVLQLTITLSSVANGPLLGIFTAGVMLPWVNS 456

Human   436 KGALGGLLTGITLSFWVAI--------GAFIYPAPASKTWPLPLSTDQCIKSNVTATGPP----- 487
            ||||.|..:.:.:..|:.:        |..:|...       |.||..|   |.|..|.|
  Fly   457 KGALLGGFSSLIVMAWMCVSAQRDLVTGDLVYKRK-------PYSTMGC---NYTFAGEPREFAS 511

Human   488 -----VLSSRPGIADTWYSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLFC 547
                 .:||.|......|.|||||::..|.|..||..::.||:......:.:...|:.|....
  Fly   512 LALDGAISSVPSAPFQLYRISYLYFTLFGALVTIVVALVTSLLLRETDLDGVDTRLLTPFVRR-- 574

Human   548 FWSKKYKTLCWCGVQH------DSGTEQEN 571
             |.::.:        |      |||.:..|
  Fly   575 -WLERRR--------HRRSKIPDSGQKSSN 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	188/563 (33%)
CG9657	NP_001284983.1	SLC5sbd_NIS-SMVT	16..554	CDD:271383	186/555 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850