DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ifit1 and Utx

DIOPT Version :9

Sequence 1:NP_032357.2 Gene:Ifit1 / 15957 MGIID:99450 Length:463 Species:Mus musculus
Sequence 2:NP_609368.3 Gene:Utx / 34377 FlyBaseID:FBgn0260749 Length:1136 Species:Drosophila melanogaster


Alignment Length:495 Identity:95/495 - (19%)
Similarity:166/495 - (33%) Gaps:161/495 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse    24 KLLFENND-IPDLEVRISEQVQFLDIKNPLG----------MHNLLAYVRHLKGQQDEALQSLKE 77
            :|.||::. |.:|:   |....|||:.|...          :.||..|:.:  ||..|:..|...
  Fly     3 QLTFEDDCLIRELD---SRYYGFLDLSNSKNAELRNLVQQTITNLQNYIAN--GQVHESKNSSDN 62

Mouse    78 AEALIQSEQLSKRSLATWGNCAWLHYHRGSLAEAQIYLDKVEKVCKEFSSPFRYRLECAEMDCEE 142
            ..|:.:.|..:                     :|..:::.......:.:.||       |.|.:|
  Fly    63 KNAIQKFEPST---------------------QAGEHMENTSSRNNDDTKPF-------EQDAKE 99

Mouse   143 GW--------------ALLKCGG-----GNYKQAMACFAKALKVEPENPEYNTGYAV-----VAY 183
            ..              ||.|.|.     |.|.:|::.:.|.|:....|  |.|.:|.     |||
  Fly   100 KVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEALSAYQKYLRFRENN--YWTNHAFIYGIGVAY 162

Mouse   184 RQDLDDNFISLEPLRKAVRLNPEDPYLK----------VLLALKLQDLGEHVEAEAHIEEAL--- 235
                    ..|...:.|::...|..||.          :.|.|.|:..||...|..|::.||   
  Fly   163 --------FKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLMLKHCGEFHIALKHLQLALLYT 219

Mouse   236 -SSTSCQSYV-------------------------------IRYAAKYFR--------------R 254
             .||..:..|                               :...|..:|              :
  Fly   220 YPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLELKADVYRQLGWMYHCVECLGEK 284

Mouse   255 KHRVDKALHLLNRALQASPSSGYLHYQKGLCYKQQISQLRTS----RNRQPRRQDNVQELAQQAI 315
            |.|...||:.|.::::|.|.||...|..|.|| ..|:::..:    ||...:.:.|........:
  Fly   285 KEREANALNFLQKSIEADPKSGQSLYLLGRCY-AGINKVHDAFLAYRNSVEKSEGNADTWCSIGV 348

Mouse   316 HEFQETLKLRPTFEM-AYVCMAEVQAEIHQYEEAERNFQKALNNKTLVAHIEQDIHLRYGRFLQF 379
            ...|:.   :||..: ||:|..::          :::.:.|..|..::......:...|..:|..
  Fly   349 LYQQQN---QPTDALQAYICAVQL----------DKDHKAAWTNLGILYESCGQLRDAYACYLNA 400

Mouse   380 HKQSEDKAITLYLKGLKVEEKSFAWRKLLTALEKVAERRV 419
            .||     |:.....|..::::...:|....|.|...:|:
  Fly   401 TKQ-----ISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRI 435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ifit1NP_032357.2 TPR 1 52..85 8/42 (19%)
TPR_12 54..124 CDD:290160 10/69 (14%)
TPR repeat 55..86 CDD:276809 8/30 (27%)
TPR repeat 91..121 CDD:276809 1/29 (3%)
TPR 2 92..126 1/33 (3%)
TPR 3 136..171 12/53 (23%)
TPR repeat 136..166 CDD:276809 11/48 (23%)
TPR_16 145..208 CDD:290168 19/72 (26%)
TPR repeat 171..203 CDD:276809 9/36 (25%)
TPR 4 174..207 8/37 (22%)
type_IV_pilW <194..354 CDD:131573 42/223 (19%)
TPR repeat 208..236 CDD:276809 11/41 (27%)
TPR 5 209..241 13/45 (29%)
TPR 6 242..275 10/77 (13%)
TPR repeat 242..270 CDD:276809 8/72 (11%)
Interaction with the 5'-triphosphate group of PPP-RNA. /evidence=ECO:0000250 247..253 1/5 (20%)
TPR repeat 275..324 CDD:276809 11/52 (21%)
TPR 7 294..328 5/37 (14%)
TPR 8 329..362 5/33 (15%)
TPR repeat 329..356 CDD:276809 3/27 (11%)
TPR 9 367..401 6/33 (18%)
TPR 10 426..459
UtxNP_609368.3 TPR repeat 147..181 CDD:276809 10/43 (23%)
TPR_11 156..216 CDD:290150 15/67 (22%)
TPR repeat 186..216 CDD:276809 7/29 (24%)
TPR repeat 228..255 CDD:276809 1/26 (4%)
TPR_11 264..337 CDD:290150 18/73 (25%)
TPR repeat 265..300 CDD:276809 7/34 (21%)
TPR repeat 307..334 CDD:276809 7/27 (26%)
TPR_11 339..402 CDD:290150 11/75 (15%)
TPR repeat 339..369 CDD:276809 7/32 (22%)
TPR_1 340..373 CDD:278916 6/45 (13%)
TPR repeat 374..402 CDD:276809 4/27 (15%)
JmjC 870..978 CDD:202224
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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