DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP51A1 and Cyp6a21

DIOPT Version :9

Sequence 1:	NP_000777.1	Gene:	CYP51A1 / 1595	HGNCID:	2649	Length:	509	Species:	Homo sapiens
Sequence 2:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	110/501 - (21%)
Similarity:	191/501 - (38%)	Gaps:	81/501 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    34 SMLLIACAFTLSLV-YLI---RLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENA 94
            ::||.|   .|:|| ||:   |....|...|....:.|..:...:..:..|.:|.    |...:.
  Fly     5 TVLLTA---LLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFN----EIWTSY 62

Human    95 YEKY---GPVFSFTMVGKTFTYLLGSDAAALL-------FNSKNEDLNAEDVYSRLTTPVFGKGV 149
            |.|:   ||...|....:...::|.:..|..:       |..:....|.||      .|:.|:..
  Fly    63 YNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPED------DPLSGQLF 121

Human   150 AYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKN----VFEALSELIIL 210
            ..|  ...:...:..|.|.......|.....:.|...|:.:.:|::..|:    |.|.|:.....
  Fly   122 LLD--GQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTD 184

Human   211 TASHCLHGKEI--------------RSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDR 261
            ....|..|.|.              |..|.|   |....:..||.::         .|:..|  |
  Fly   185 VIGTCAFGIECSSLKDPDAEFREMGRRSLTE---QRLGPVGIGFVNS---------FPNLAR--R 235

Human   262 AHRE-----IKDIFYKAIQK----RRQSQEKIDDILQTLLDATYK--------DGRPLTDDEVAG 309
            .|.:     |:..|.:.:::    |.|:..:.:|.:..|:|...|        :...||.:|:|.
  Fly   236 LHMKMTAEPIERFFMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAA 300

Human   310 MLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIK 374
            .......||..|||||..:..:.||:::.:|.:...|.:.|..:....|.|:.:|||..||:.:.
  Fly   301 QAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVS 365

Human   375 ETLRLRPPIMIMMRMARTPQTVAG---YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDN 436
            |||||...:.::.|.......|.|   |.|..|..|.:......|.:..:.....||||.:..:.
  Fly   366 ETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPER 430

Human   437 PASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLID 482
            ....:...::|||.|...|||..|..:|.:...:.:::.::|.:.:
  Fly   431 VKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP51A1	NP_000777.1	p450	67..483	CDD:299894	99/464 (21%)
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	99/468 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910