DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP27B1 and Cyp12a5

DIOPT Version :9

Sequence 1:	NP_000776.1	Gene:	CYP27B1 / 1594	HGNCID:	2606	Length:	508	Species:	Homo sapiens
Sequence 2:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	131/495 - (26%)
Similarity:	221/495 - (44%)	Gaps:	91/495 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    39 DIPGPSTPSFLAELFCKGGLSRLHEL--------QVQGAAHFGPVWLASFGTVRTVYVAAPALVE 95
            :||..:..|..|:....||..:..|:        |..|...|.|..:...|.|.|   ..|...|
  Fly    49 EIPKANILSLFAKSALPGGKYKNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMT---HNPKDFE 110

Human    96 ELLRQEGPRPERCSFSPWTE----HRRCRQR-----ACGLLTAEGEEWQRLRSLLAPLLLRPQAA 151
            .:.|.||..|    |.|.::    ||...::     ..|::.::|:.|...||::.|:|::|:..
  Fly   111 VVFRNEGVWP----FRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNV 171

Human   152 ARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFY----KFGLEGIAAVLLGSRLGCLEA 212
            ..|...::.|..:.|..::..|...|      ::|.|.|.    ::.||.::.|.|..:||.|
  Fly   172 RLYFKKMSQVNQEFVELIKEIRDAST------QEVPGNFLETINRWTLESVSVVALDKQLGLL-- 228

Human   213 QVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH-----LVPGPW--------GRLCRDWDQM---- 260
                      |..|....:|.|...:..:..|     :.|..|        .::.|..|.:
  Fly   229 ----------RESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYFKTPLLKKMLRTMDSVQEVT 283

Human   261 FAFAQRHVERREAEAAMRNG-GQPEKD---LESGAHLTHFLFREELPAQSILGNVTELLLAGVDT 321
            ..:....:||.|.||  :.| .:||.:   ||.       |.:.:....:::  ..::|:|||||
  Fly   284 LKYVDEAIERLEKEA--KEGVVRPEHEQSVLEK-------LLKVDKKVATVM--AMDMLMAGVDT 337

Human   322 VSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPG 386
            .|:|.:..|..|:::||.|..|..|:...|....|.:..|: :..:|.|:|.:||..|:||:|.|
  Fly   338 TSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEAS-MKNVPYLRACIKESQRVYPLVIG 401

Human   387 NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWL-------GEGP-----T 439
            |:|...:|..:..|.:|..|:|::....:......||:|..|.|.|||       |:.|     |
  Fly   402 NARGLTRDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDLKT 466

Human   440 PHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
            .:||..||||||.|.|:|:|:.|:||::..|:::.:|.|:
  Fly   467 KNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP27B1	NP_000776.1	p450	41..505	CDD:278495	130/493 (26%)
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	124/463 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.880