Protein Alignment CYP27B1 and shd

DIOPT Version :10

• Sequence 1: NP_000776.1
• Gene: CYP27B1 / 1594
• HGNCID: 2606
• Length: 508
• Species: Homo sapiens
• Sequence 2: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 131/537 - (24%)
• Similarity: 222/537 - (41%)
• Gaps: 98/537 - (18%)

Human    30 YHS----------ARRSLADIPGPSTPSFLAE------LFCKGGLSRLHELQVQGAAHFGPVWLA 78
            ||:          .||.:.|||||....||..      .|.:..:::|||:.......:|.:.|.
  Fly    42 YHAELIQPEAPKRRRRGIWDIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIVLE 106

Human    79 SF-GTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTE-------HRRCRQRACGLLTAEGEEWQ 135
            .. ..|..|::.....:|::|:.    |.:..|.|.||       .|..|..:.|::..:|..||
  Fly   107 VMPSNVPIVHLYNRDDLEKVLKY----PSKYPFRPPTEIIVMYRQSRPDRYASVGIVNEQGPMWQ 167

Human   136 RLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALV----RDVAGEFYKFGLE 196
            ||||.|...:..|:....:...||.|..|.:..||.:|    .|..||    .::|.   ..|||
  Fly   168 RLRSSLTSSITSPRVLQNFLPALNAVCDDFIELLRARR----DPDTLVVPNFEELAN---LMGLE 225

Human   197 GIAAVLLGSRLG--CLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPW----GRLCR 255
            .:..::||.|:|  .::.:.|........||..:|:|...:        :...|.|    .:..|
  Fly   226 AVCTLMLGRRMGFLAIDTKQPQKISQLAAAVKQLFISQRDS--------YYGLGLWKYFPTKTYR 282

Human   256 D--------WDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAH--LTHFLFREELPAQSILGN 310
            |        :|.:.......:|..:..||.      |.|..:|..  ..:.|..::|..:.....
  Fly   283 DFARAEDLIYDVISEIIDHELEELKKSAAC------EDDEAAGLRSIFLNILELKDLDIRDKKSA 341

Human   311 VTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATV----LSQLPLLK 371
            :.:.:.||::|::|||.:.|..::..|.....:.||.        ..|....:    |:.....|
  Fly   342 IIDFIAAGIETLANTLLFVLSSVTGDPGAMPRILSEF--------CEYRDTNILQDALTNATYTK 398

Human   372 AVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCH--YATSRDPAQFPEPNSFRPARWL 434
            |.::|..||.|.....:|:.::|:.:..|.:...|:| ||.  .|..:| :.|.....|.|.||:
  Fly   399 ACIQESYRLRPTAFCLARILEEDMELSGYSLNAGTVV-LCQNMIACHKD-SNFQGAKQFTPERWI 461

Human   435 GEGPTPHPF------ASL--PFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKT 491
              .|....|      ||:  |||.|:|||.|:|..|:|:.:.||:::..|:|.   ...|:..:.
  Fly   462 --DPATENFTVNVDNASIVVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVS---FVKPLETEF 521

Human   492 RTVLVPERSINLQFLDR 508
            ..:|.|:..::|:..||
  Fly   522 EFLLAPKTPLSLRLSDR 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP27B1	NP_000776.1	CYP27B1	68..503	CDD:410741	113/476 (24%)
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	113/473 (24%)