DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CYP27A1 and Cyp12e1

DIOPT Version :9

Sequence 1:NP_000775.1 Gene:CYP27A1 / 1593 HGNCID:2605 Length:531 Species:Homo sapiens
Sequence 2:NP_650003.4 Gene:Cyp12e1 / 41272 FlyBaseID:FBgn0037817 Length:522 Species:Drosophila melanogaster


Alignment Length:515 Identity:135/515 - (26%)
Similarity:236/515 - (45%) Gaps:66/515 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    56 SLEE------IPRLGQLRFFFQLFVQG--YA-LQLHQLQVLYKAKYGPMWM--SYLGPQMHVNLA 109
            :|||      ||...:|: ..:.|:.|  |. |.:|::.:....:||.::.  |..|..:.:.: 
  Fly    31 NLEEAKPYADIPGPSKLQ-LIRAFLPGGLYKNLPVHEMFLDMNRQYGSIFRMPSVAGTDLVLTM- 93

Human   110 SAPLLEQVMRQEGKYPVRNDMELW----KEHR----DQHD-LTYGPFTTEGHHWYQLRQALNQRL 165
            :....|.:.|.||:||.|...|:.    :.||    |.:| ||.|    .|..|.::|.|:|..|
  Fly    94 NPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSG----NGPAWGKMRTAVNPIL 154

Human   166 LKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCL- 229
            |:|..|.||.....:|.|:|:.|:..:| :..:.....|.|....:..:|:||.:.....:|.| 
  Fly   155 LQPRNAKLYMTNLVQVSDEFLERIRIIR-DPVTQEMPDDFAVDIRHLVIESICSVALNTHLGLLG 218

Human   230 ----QRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKL 290
                .:.|.:..:.....:.|.||..:...|   |....:|.:|:.:...:.|..|....|...|
  Fly   219 EQRNNKDIQKLVLALQDVVELGFQLDIMPAF---WKYLPMPNFKKLMRSLDTITDFCYFHIGNAL 280

Human   291 EDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDP 355
            :.:|...:|...:.|.:...|...||  :...:.|:....:||.||.|.|..||...|:.|||.|
  Fly   281 KRIEEDAKAGTLNEIGLETSLLEKLA--RFDRQTAVIIAMDLLFAGADPTLVTLGGILFSLSKSP 343

Human   356 EIQEALHEEVVGVVPAGQVPQHKD-------FAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV 413
            :.|..|.||:.|::|      :||       ..::|.|:|.:||.:|:||:.|...|.:..::.:
  Fly   344 DKQARLLEEIRGILP------NKDSSLTIENMRNLPYLRACIKEGIRMYPIGPGTLRRMPHDVVL 402

Human   414 DGFLFPKNTQF-VFCHYVVSRDPTAFSEPESFQPHRWLRN-------SQPATPRIQHPFGSVPFG 470
            .|:.....|.. :..:|.::.......:...|.|.||||:       .:.||     ||..:|||
  Fly   403 SGYRVVAGTDVGIAANYQMANMEQFVPKVREFIPERWLRDESNSHLVGETAT-----PFMYLPFG 462

Human   471 YGVRACLGRRIAELEMQLLLARLIQKYKVVL-APETGELKSVARIVLVPNKKVGLQFLQR 529
            :|.|:|.|:||.::.:::.::||::.:|:.. .|.....|  |:..:.||.....:|::|
  Fly   463 FGPRSCAGKRIVDMMLEIAISRLVRNFKIGFDYPIENAFK--AQFFVQPNIPFKFKFIER 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CYP27A1NP_000775.1 p450 61..526 CDD:306555 129/499 (26%)
Sterol-binding. /evidence=ECO:0000255 384..398 6/13 (46%)
Cyp12e1NP_650003.4 p450 63..517 CDD:299894 123/477 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 194 1.000 Domainoid score I3171
eggNOG 1 0.900 - - E2759_KOG0159
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 201 1.000 Inparanoid score I3768
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48087
OrthoDB 1 1.010 - - D185685at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8467
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X156
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.880

Return to query results.
Submit another query.