Protein Alignment CYP27A1 and Cyp12c1

DIOPT Version :9

• Sequence 1: NP_000775.1
• Gene: CYP27A1 / 1593
• HGNCID: 2605
• Length: 531
• Species: Homo sapiens
• Sequence 2: NP_001287109.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 542
• Identity: 144/542 - (26%)
• Similarity: 250/542 - (46%)
• Gaps: 68/542 - (12%)

Human    23 HGARAKAAIPAALPSDKATGAPGAGPGVRRRQRSLE------EIPRLGQLRFFFQLFVQGYAL-- 79
            ||.||.:.:       .||..|.|...|::.:...|      |:|  |..|  :||| :|:..
  Fly     8 HGLRANSQL-------AATRNPDASSYVQQLESEWEGAKPFTELP--GPTR--WQLF-RGFQKGG 60

Human    80 QLHQLQV-----LYKAKYGPMWM--SYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHR 137
            :.|||.:     |||.::|.:.:  ...|....|...:....|:|.|.||::|||...|....:|
  Fly    61 EYHQLGMDDVMRLYKKQFGDICLIPGLFGMPSTVFTFNVETFEKVYRTEGQWPVRGGAEPVIHYR 125

Human   138 DQHDLTY-----GPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESA 197
            ::....:     |.| ..|..|.:.|.|:|..|::....|:|......|...|:.|:.::| :..
  Fly   126 NKRKDEFFKNCMGLF-GNGAEWGKNRSAVNPVLMQHRNVAIYLKPMQRVNRQFVNRIREIR-DKE 188

Human   198 SGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQN--SLYATFLPKW 260
            |.....|......:...|::..:..::.:|.|:.:.|....:      .:|:|  .|..:|....
  Fly   189 SQEVPGDFMNTINHLTFESVATVALDRELGLLREANPPPEAS------KLFKNIEVLMDSFFDLG 247

Human   261 TRPVL------PFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQ 319
            .||.|      |.:|::....:.||......:::.:|.::.  :::..|.......|..||   |
  Fly   248 VRPSLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDR--KSSQGDSNDHKSVLEQLL---Q 307

Human   320 LSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFA--- 381
            :..:.|:....::||.||||||..::..|.:|:|:||.|:.|.|||:..:.:    .|.:|.
  Fly   308 IDRKLAVVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLTS----LHSEFTVED 368

Human   382 --HMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESF 444
              .:|.|:||:||:||||||...|:|....::.:||:..||.|:.:..:..:.:|...:...:.|
  Fly   369 MKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNSFLLKDDRLYPRAKEF 433

Human   445 QPHRWLR-----NSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPE 504
            .|.||||     .|.....:..:.|..:|||:|.|.|:|:||.:|||:|.:|.|::.:.:.....
  Fly   434 IPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLVRNFHIEYNYS 498

Human   505 TGELKSVARIVLVPNKKVGLQF 526
            | |.....|.:..||..:..:|
  Fly   499 T-EKPYKCRFLYKPNIPLKFKF 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP27A1	NP_000775.1	p450	61..526	CDD:306555	132/496 (27%)
		Sterol-binding. /evidence=ECO:0000255	384..398		9/13 (69%)
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	129/479 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.780