DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP27A1 and Cyp12b2

DIOPT Version :9

Sequence 1:	NP_000775.1	Gene:	CYP27A1 / 1593	HGNCID:	2605	Length:	531	Species:	Homo sapiens
Sequence 2:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	133/486 - (27%)
Similarity:	229/486 - (47%)	Gaps:	32/486 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    52 RRQRSLEEIPRLGQLRFFFQLFVQGYALQ---LHQLQVLYKAKYGPMWM--SYLGPQMHVNLASA 111
            ::.||..|||....|| ....|:.|.||:   |.|:..|.:..||.::.  ..:|....|...:.
  Fly    48 QQARSFGEIPGPSLLR-MLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNP 111

Human   112 PLLEQVMRQEGKYPVRNDMELWKEHRDQH--DL---TYGPFTTEGHHWYQLRQALNQRLLKPAEA 171
            ...|...|.||.:|:|..:|....:|..|  |:   ..|..:.:|..|..:|..:|..|:|....
  Fly   112 DDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNV 176

Human   172 ALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPED 236
            .......:::..:|:.:|:..| ...:....:|.......:|.|:|.::....|:|.|..:...:
  Fly   177 RQNLPQLDQISKEFIDKLETQR-NPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPN 240

Human   237 TVTFVRSIGLMFQNSLYATFLPK-WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAA 300
            .....:.:...|..|......|. ||......:|::|..::.|.......|:..:...     ..
  Fly   241 ADRLAKHMRDFFNYSFQFDVQPSIWTFYKTAGFKKFLKTYDNITDITSNYIETAMRGF-----GK 300

Human   301 GPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEV 365
            ..|| :....|..||   :.:.:.|:..:.::||||:||||:.....||||:::|..||.|..|:
  Fly   301 NDDG-KTKCVLEQLL---EHNKKVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQEKLRREL 361

Human   366 VGVVPAGQVP-QHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHY 429
            :.::|..:.. ..::..:||.|:|.:||.||:..:.|.|.||..|::.:.|:..|:.|..:....
  Fly   362 LRILPTTKDSLTDQNTKNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTGVLMGVL 426

Human   430 VVSRDPTAFSEPESFQPHRWLRN-------SQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQ 487
            .:|.|...|::...|.|.|||::       :.||. |.::||..:|||:|.|.|:|:||||||::
  Fly   427 ELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAA-RTRNPFVYLPFGFGPRTCIGKRIAELEIE 490

Human   488 LLLARLIQKYKVVLAPETGELKSVARIVLVP 518
            .||.||::.|||...||| .::..:.|:|.|
  Fly   491 TLLVRLLRSYKVSWLPET-PIEYESTIILSP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP27A1	NP_000775.1	p450	61..526	CDD:306555	129/477 (27%)
CYP27A1	NP_000775.1	Sterol-binding. /evidence=ECO:0000255	384..398		7/13 (54%)
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	125/464 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.780