DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP27A1 and Cyp301a1

DIOPT Version :9

Sequence 1:	NP_000775.1	Gene:	CYP27A1 / 1593	HGNCID:	2605	Length:	531	Species:	Homo sapiens
Sequence 2:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	138/537 - (25%)
Similarity:	228/537 - (42%)	Gaps:	75/537 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAALGCARLRWALRGAGRGLCPHGARA-KAAIPA---------ALPSDKATGAPGAGPGVRRRQR 55
            ::..|..|.:......|...|||.|.: :|:.|.         |||.::   .||..|
  Fly    26 ISGAGSRRAQCRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQ---IPGPKP------- 80

Human    56 SLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPM--WMSYLGPQMHVNLASAPLLEQVM 118
                ||.||.......:..|.....:.::..|...:||.:  :...:|....:.:..|..:|:..
  Fly    81 ----IPILGNTWRLMPIIGQYTISDVAKISSLLHDRYGRIVRFGGLIGRPDLLFIYDADEIEKCY 141

Human   119 RQEGKYPVRNDMELWKEHRDQ------HDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDA 177
            |.||..|.|..|....:::..      .||. |.....|..|.:.|..:.:.:|:.:....|...
  Fly   142 RSEGPTPFRPSMPSLVKYKSVVRKDFFGDLG-GVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQP 205

Human   178 FNEVIDDFMTRLDQLRAESASGNQ--VSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVT- 239
            ...:.:||:.|.:.|..|    ||  ..|.....:.::||.|..:..:.|:|||:.::..|:..
  Fly   206 LEVITEDFLVRCENLLDE----NQELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQ 266

Human   240 --------FVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLID---EKLEDM 293
                    .:|::..:...:.|..:.|      .|.|.||:...|.......|.|.   |:|:..
  Fly   267 QIIDAAKYALRNVATLELKAPYWRYFP------TPLWTRYVKNMNFFVGVCMKYIQSATERLKTQ 325

Human   294 EAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQ 358
            :..|:|..|..::       .:...|...:.|.....:|::.|:||.|..:...||.|:..|..|
  Fly   326 DPSLRAGEPSLVE-------KVILSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQ 383

Human   359 EALHEEVVGVVPAGQVPQHKDFAHMPL------LKAVLKETLRLYPVVPTNSRIIEKEIEVDGFL 417
            :.:|||:..::|....|     ..:||      ||..:||..|:|..|..|.|.:.::..:.|:.
  Fly   384 QKVHEELKRLLPDPNTP-----LTIPLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQ 443

Human   418 FPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIA 482
            .||..|.||...|........::..:|:|.|||:.....||...|||.|:|:|||.|.|||||.|
  Fly   444 VPKGVQAVFPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFA 508

Human   483 ELEMQLLLARLIQKYKV 499
            :||||:|||:|::.||:
  Fly   509 DLEMQILLAKLLRNYKL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP27A1	NP_000775.1	p450	61..526	CDD:306555	122/467 (26%)
CYP27A1	NP_000775.1	Sterol-binding. /evidence=ECO:0000255	384..398		7/19 (37%)
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	126/484 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	1	0.950	-	0	Normalized mean entropy	S4770
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820