Protein Alignment NKX2-3 and Nkx2-3

DIOPT Version :10

• Sequence 1: NP_660328.2
• Gene: NKX2-3 / 159296
• HGNCID: 7836
• Length: 364
• Species: Homo sapiens
• Sequence 2: NP_032725.1
• Gene: Nkx2-3 / 18089
• MGIID: 97348
• Length: 362
• Species: Mus musculus
• Alignment Length: 365
• Identity: 330/365 - (90%)
• Similarity: 340/365 - (93%)
• Gaps: 4/365 - (1%)

Human     1 MMLPSPVTSTPFSVKDILNLEQQHQHFHGAHLQADLEHHFHSAPCMLAAAEGTQFSDGGEEDEED 65
            ||||||||||||||||||||||| :|||||||||:||.||||||||||.||||||||.||||||:
Mouse     1 MMLPSPVTSTPFSVKDILNLEQQ-RHFHGAHLQAELEQHFHSAPCMLATAEGTQFSDAGEEDEEE 64

Human    66 EGEKLSYLNSLAAADGHGDSGLCPQGYVHTVLRDSCSEPKEHEEEPEVVRDRSQKSCQLKKSLET 130
            ||||||||||||||:||||||||||.||||||||:||.|||.||  |||.:|||||||||||||.
Mouse    65 EGEKLSYLNSLAAAEGHGDSGLCPQSYVHTVLRDACSGPKEQEE--EVVSERSQKSCQLKKSLEA 127

Human   131 AGDCKAAEESERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIW 195
            |||||.:|:.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   128 AGDCKTSEDGERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIW 192

Human   196 FQNRRYKCKRQRQDKSLELGAHAPPPPPRRVAVPVLVRDGKPCVTPSAQAYGAPYSVGASAYSYN 260
            ||||||||||||||||||||.||||||||||||||||||||||||||||.||:||.|||.|||||
Mouse   193 FQNRRYKCKRQRQDKSLELGTHAPPPPPRRVAVPVLVRDGKPCVTPSAQTYGSPYGVGAGAYSYN 257

Human   261 SFPAYGYGNSAAAAAAAAAAAAAAAAYSSSYGCAYPAGGGGGGGGT-SAATTAMQPACSAAGGGP 324
            ||||||||||||||||||||||||||||.|||||||.||||||||| |||||||||||||.|||.
Mouse   258 SFPAYGYGNSAAAAAAAAAAAAAAAAYSGSYGCAYPTGGGGGGGGTASAATTAMQPACSATGGGS 322

Human   325 FVNVSNLGGFGSGGSAQPLHQGTAAGAACAQGTLQGIRAW 364
            ||||||||||||||.|||||||.|||:||.||||||||||
Mouse   323 FVNVSNLGGFGSGGGAQPLHQGAAAGSACTQGTLQGIRAW 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKX2-3	NP_660328.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..153		16/20 (80%)
		Homeodomain	149..205	CDD:459649	55/55 (100%)
Nkx2-3	NP_032725.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	126..149		17/22 (77%)
		Homeodomain	146..202	CDD:459649	55/55 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..222		17/18 (94%)