DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3g and CG5028

DIOPT Version :9

Sequence 1:	NP_032349.1	Gene:	Idh3g / 15929	MGIID:	1099463	Length:	393	Species:	Mus musculus
Sequence 2:	NP_001097922.1	Gene:	CG5028 / 43102	FlyBaseID:	FBgn0039358	Length:	402	Species:	Drosophila melanogaster

Alignment Length:	347	Identity:	182/347 - (52%)
Similarity:	251/347 - (72%)	Gaps:	7/347 - (2%)

- Green bases have known domain annotations that are detailed below.

Mouse    47 PSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVS-SNADEEDIRNAIMAIRRN 110
            |||:|||||.|||:||.|||||||.:|:.:||:...|:|||.:.:. |....:|:..||.:|:||
  Fly    50 PSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIDPSTEGNDDLDYAITSIKRN 114

Mouse   111 RVALKGNIET-NHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRENTEGEY 174
            .||||||||| :.:|  :..|||..:|..||||.||:||||.||:..||.|||::::|:||:|||
  Fly   115 GVALKGNIETKSQSL--TEVSRNVAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEY 177

Mouse   175 SSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREV 239
            :.||||||.|:|||:|::|...:.|:|.|||:.|:::.|||||.:||||||||.|||||:....|
  Fly   178 AMLEHESVPGIVESMKVVTVENAERVARYAFEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRV 242

Mouse   240 AAHYPQITFDSMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYA 304
            ...||::..::||:|||.||.||.|.|||||.|.||||.||:||..||:||.||::|.|||..||
  Fly   243 HKDYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHYA 307

Mouse   305 VFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQ 369
            :||..|||||.:||.||||||.|.:.||..||:||....:|..|::||..::.|:.:.||||||.
  Fly   308 IFEPGTRNTGTAIAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVNDAIRTPDIGGT 372

Mouse   370 GTTSQAIQDIIRHIRIINGRAV 391
            .:::..:::|   ::|::.:.|
  Fly   373 NSSTDVVENI---LKILSAKRV 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3g	NP_032349.1	mito_nad_idh	52..383	CDD:272942	176/332 (53%)
CG5028	NP_001097922.1	mito_nad_idh	55..386	CDD:272942	176/335 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849842
Domainoid	1	1.000	345	1.000	Domainoid score	I1051
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55803
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2123
Isobase	1	0.950	-	0	Normalized mean entropy	S556
OMA	1	1.010	-	-		QHG53770
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	1	1.000	-	-		otm43366
orthoMCL	1	0.900	-	-		OOG6_101342
Panther	1	1.100	-	-	LDO	PTHR11835
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R585
SonicParanoid	1	1.000	-	-		X402
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750